RESUMO
Nocardiosis is an increasing clinical problem, especially in immunocompromised patients. The offending species is almost always Nocardia asteroides. Cryptococcosis is also an increasing problem in the immunosuppressed. We describe a patient with probable disseminated cryptococcosis followed by disseminated Nocardia brasiliensis infection. Only eight patients with disseminated N brasiliensis infection have been described, to our knowledge, in the United States.
Assuntos
Criptococose/complicações , Nocardiose/complicações , Infecções Oportunistas/complicações , Dermatopatias Infecciosas/complicações , Dermatomicoses/complicações , Humanos , Masculino , Pessoa de Meia-IdadeAssuntos
Hemoglobinas Anormais , Adulto , Sequência de Aminoácidos , Aminoácidos/análise , Eletroforese das Proteínas Sanguíneas , Quimotripsina , Eletroforese em Gel de Poliacrilamida , Feminino , Glutamatos , Humanos , Lactente , Recém-Nascido , Jamaica , Fragmentos de Peptídeos/análise , Texas , ValinaRESUMO
A new alpha chain variant Hb Spanish Town, a27 Glutamic acid-Valine, awas detected in the cord blood of a Jamaica Negro infant. In the mother the adult component (a2 Spanish TownB2) has an electrophoretic mobility between haemoglobins S and F at alkaline pH and measures 11.0-12.0 percent of the total haemoglobin. (Summary)
Assuntos
Humanos , Recém-Nascido , Lactente , Adulto , Feminino , Hemoglobinas Anormais , Sequência de Aminoácidos , Aminoácidos/análise , Eletroforese das Proteínas Sanguíneas , Quimotripsina , Eletroforese em Gel de Poliacrilamida , Glutamatos , Jamaica , Fragmentos de Peptídeos/análise , Texas , ValinaRESUMO
15,661 cord bloods from Jamaican infants were examined for abnormal hemoglobins using alkaline cellulose acetate electrophoresis for the initial screening, supplemented by acid agar gel electrophoresis for samples exhibiting abnormal hemoglobin bands. Of the 16 electrophoretic variants which were detected, six were fully characterized and found to be: four Hb F Port Royal (alpha2 Ggamma2 125 Glu replaced by Ala) and two Hb F Victoria Jubilee (alpha2Agamma2 80 Asp replaced by Tyr). The Hb F Port Royal samples each constituted about one eighth of the total Hb F as did seven additional samples presumed to be Hb F Port Royal. The infants with this variant exhibited no special hematological characteristics or other consistent associations. Both Hb F Victoria Jubilee samples occurred in somewhat lower proportions of the total Hb F compared with Hb F Port Royal and exhibited an apparent increase of free alpha chains in the whole hemolysate. The data available on detectable gamma chain variants suggest that a specific point mutation may occur in either a HbGgamma or a HbAgamma locus.
Assuntos
Hemoglobina Fetal , Hemoglobinas Anormais , Cromatografia em Gel , Eletroforese em Acetato de Celulose , Feminino , Variação Genética , Hemoglobina A , Humanos , Recém-Nascido , Jamaica , MasculinoRESUMO
15,661 cord bloods from Jamaican infants were examined for abnormal hemoglobins using alkaline cellulose acetate electrophoresis for the initial screening, supplemented by acid agar gel electrophoresis for samples exhibiting abnormal hemoglobin bands. Of the 16 electrophoretic variants which were detected, six were fully characterized and found to be: four Hb F Port Royal (alpha2 Ggamma2 125 Glu replaced by Ala) and two Hb F Victoria Jubilee (alpha2Agamma2 80 Asp replaced by Tyr). The Hb F Port Royal samples each constituted about one eighth of the total Hb F as did seven additional samples presumed to be Hb F Port Royal. The infants with this variant exhibited no special hematological characteristics or other consistent associations. Both Hb F Victoria Jubilee samples ocurred in somewhat lower proportions of the total Hb F compared with Hb F Port Royal and exhibited an apparent increase of free alpha chains in the whole hemolysate. The data available on detectable gamma chain variants suggest that a specific point mutation may occur in either a HbGgamma or a HbAgamma locus. (AU)
Assuntos
Humanos , Recém-Nascido , Masculino , Feminino , Hemoglobina Fetal , Hemoglobinas Anormais , Cromatografia em Gel , Eletroforese em Acetato de Celulose , Hemoglobina A , Variação Genética , JamaicaRESUMO
A new A gamma chain haemoglobin variant, haemoglobin F Victoria Jubilee, with an electrophoretic mobility slightly anodal to haemoglobin F Port Royal, was found in a Jamaican infant. The amino acid residue substitution of 80 Aspartic Acid leads to Tyrosine was associated with alanine in position 136. Haemoglobin F Victoria Jubilee constituted about 7.0 percent of the total haemoglobin F.