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ABSTRACT Quinoa (Chenopodium quinoa Wild.) is an Andean crop that originated from the Andes of South America, with great agronomic, industrial, pharmaceutical potential and also a great capacity to tolerate adverse environmental factors. In Colombia, more accurately in the Department of Nariño, Cauca, Cundinamarca and Boyacá. Shows great genetic variation, both molecular and morphological, which organization remains poorly documented. In Boyacá, there are few studies on the morphological characterization of cultivated materials, and there is no certified planting material, with farmers planting a mixture of materials. Qualitative and quantitative descriptors and principal component and cluster analyses were used to characterize the structure of the intra-population phenotypic variation in Blanca de Jericó quinoa materials grown in the Department of Boyacá. The principal component analysis explained more than 70 % of the observed variation, with the AP, LP, DP, LHS, and AHS characteristics being more variable. The cluster analysis showed grouping by characteristics, such as AP, panicle color, and the presence of pigmented axillae. Results show that the variance in morpho-phenological traits was concentrated at the intra-population, due to high variation at the inter-individual level. A more efficient selection process should be carried out to find materials or "pure" varieties with higher yields, resistance to biotic and abiotic factors, and adaptation to local conditions, which make quinoa an economically profitable crop in the Boyacá department.

RESUMEN La quinua (Chenopodium quinoa Wild.) es un cultivo andino, originario de los Andes Suramericanos, con gran potencial agronómico, industrial y farmacéutico y también con una gran capacidad para tolerar factores ambientales adversos. En Colombia, actualmente, se cultiva en los departamentos de Nariño, Cauca, Cundinamarca y Boyacá. Presenta una gran variación genética, tanto a nivel molecular como morfológica, la cual, ha sido poco documentada. En Boyacá son pocos los estudios de caracterización morfológica de materiales cultivados y no hay material de siembra certificado, por lo que los agricultores siembran una mezcla de materiales. Descriptores cualitativos y cuantitativos y un análisis de componentes principales y de agrupamiento fueron usados para caracterizar la estructura de la variación fenotípica intrapoblacional de los materiales de quinua Blanca Jericó, que son cultivados en el departamento de Boyacá. El análisis de componentes principales explicó más del 70 % de la variación observada, siendo las características más variables AP, LP, DP, LHS y AHS. El análisis clúster mostró un agrupamiento por características, tales como AP, color de la panícula y presencia de axilas pigmentadas. Los resultados mostraron que la variación en las características morfológicas estaba concentrada dentro de la población, debido a la alta variación, a nivel inter-individual. Se deben llevar a cabo procesos de selección más eficientes para encontrar materiales "puros" o variedades con más altos rendimientos, con resistencia a factores bióticos y abióticos y adaptados a las condiciones locales, para así hacer de la quinua un cultivo económicamente rentable para el departamento de Boyacá.

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Quinoa has a high nutraceutical potential because of the presence of secondary metabolites called saponins, which have industrial and medicinal uses and protect against attacks by pathogens. These compounds are found especially in the seed coat and give the grain a bitter taste; therefore, they must be eliminated before consumption. Despite the potential use in Colombia, there are few studies aimed at quantifying this metabolite. Therefore, the objective of this research was to evaluate two extraction methodologies (physical and chemical) and two methods for quantifying saponins in five quinoa genotypes grown in Colombia. The most efficient extraction method was the physical method. The saponin contents of the five genotypes were variable. The cluster analysis differentiated the genotypes into two groups: low saponin content (<4.49 mg/g seed) and high saponin content (>14.76 mg/g seeds). Blanca de Jericó had the lowest saponin content (<0.40%), and Amarilla de Maranganí had the highest content (>0.18%). Identifying more efficient methodologies for extracting and quantifying saponins will allow a better characterization of the germplasm and selection of genotypes with desirable characteristics for both consumption and industrial use.

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Chenopodium quinoa Willd. is an Andean crop with great nutritional value, economic potential, and a broad genetic and phenotypic diversity with adaptation to different conditions. In Colombia, C. quinoa is cultivated mainly in Cundinamarca, Nariño and Boyacá, where studies have been conducted to characterize the germplasm and lack of seed materials, some challenges for the quinoa crop. This work assessed agromorphological characteristics of 50 quinoa genotypes from the germplasm collection of Boyacá the using a completely randomized design on the farm in Tunja. The multivariate analysis followed by a clustering approach were conducted on agromorphological descriptors, in which 16 were qualitative descriptors (e.g, panicle shape, episperm color, leaf shape) and five quantitative descriptors (e.g, plant height, panicle number). The results showed that higher coefficients of variation were found in characteristics associated to yield. The principal component analysis (PCA) of the quantitative variables showed that the first two components explained 88 % of the total variation with the characteristics of plant height, length, diameter, and panicle number showing the highest variability. The quantitative characteristic clusters comprised length and diameter panicle, weight 1,000 seeds, and plant height, while the qualitative characteristic clusters comprised stem shape, branching habit, panicle shape, and color of the axils. The factorial analysis of mixed data discriminated the materials with outstanding morphoagronomic characteristics. Agromorphological characterization revealed a broad variability, which should be conserved and used in genetic improvement programs of C. quinoa.

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Yellow pitahaya is an exotic fruit that is rich in essential nutrients and antioxidants. In Colombia, it grows naturally in warm areas, but it is not clear which species exist because this genus presents a lot of intra and interspecific hybridization. More studies are needed in this field along with characterizations of the genotypes. This study aimed to undertake an in situ morphoagronomic evaluation of yellow pitahaya genotypes from five municipalities in Boyacá, Colombia. Measurements were taken in a completely random design. Qualitative and quantitative descriptors for cladodes, fruits and covered production systems were evaluated with a descriptive analysis, Spearman correlation variance, and multivariate and cluster analysis. The results showed that cladode characteristics such as cladode width, distance between areoles, number of spines, length of areoles, margin ribs of cladode and waxiness could be used to identify Megalanthus spp. Characteristics such as weight (270-274 g), size (100 mm), color of the fruit and pulp as well as acidity (0.18) and soluble solids (15.7) were highly variable between the genotypes. Genotypes with good morphological and fruit characteristics were identified (Gen2 and Gen9), which can provide the bases for the selection of pitahaya that satisfy the needs of farmers and consumers.

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Quinoa is an ancestral crop in the Andean region, characterized by its adaptability to different agroclimatic conditions, great nutritional value, and broad genetic variability. A preliminary approach for understanding the genetics of quinoa materials entails a morphologic characterization, which can provide the basis for the selection of materials that satisfy the needs of farmers and consumers. Therefore, this study aimed to evaluate the phenotypic characteristics of thirty genetic C. quinoa accessions for the selection of outstanding accessions in terms of yield and grain quality. A randomized complete block design was used, with nine replications for each accession under greenhouse conditions. Nine quantitative and twelve qualitative descriptors were evaluated with descriptive analysis, Spearman correlation variance, and multivariate and cluster analysis. The results showed that the accessions with heights greater than the average (>176.72 cm) and long panicles (>57.94 cm) presented lower yields and smaller seed sizes, thus decreasing the grain quality. The multivariate and cluster analyses established groups of accessions with good yields (>62.02 g of seeds per plant) and stable morphological characteristics. The proposed selection index, based on yield components and morphological descriptors, indicated four accessions as potential parents for quinoa breeding programs in Colombia.

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Introducción: Las úlceras del pie diabético resultan las complicaciones más frecuentes en las personas con diabetes. Se conocen diferentes formas de tratamiento para esta enfermedad, con más o menos efectividad, pero no resuelven el problema en la totalidad de los casos. El estimulador eléctrico Stimul W® y el medicamento Heberprot-P® se han empleado, de manera independiente y con resultados satisfactorios, como alternativas para el tratamiento de estas lesiones. Comprobar si la acción combinada de ambos procedimientos permite alcanzar mejores resultados, permitiría contribuir a resolver un problema de alta prevalencia mundial. Objetivo: Exponer el resultado de la aplicación de la combinación del estimulador Stimul W® y el medicamento Heberprot-P® en el tratamiento de un paciente con úlcera del pie diabético. Presentación del caso: Paciente masculino de 69 años de edad, con diabetes mellitus de tipo 2, que presentaba una úlcera del pie diabético en la parte externa del pie derecho, con abundante tejido necrótico en forma de fístula en la base de los dos dedos restantes y falta de granulación. Los tratamientos anteriores no dieron el resultado esperado. Se decidió, como terapia de curación, aplicar durante 12 sesiones la combinación del estimulador Stimul W® y el medicamento Heberprot-P®. Conclusiones: Se logró la cicatrización de la lesión, al obtener un 100 por ciento de tejido de granulación y la disminución significativa de sus dimensiones, lo que mostró que la terapia aplicada constituye una alternativa para el tratamiento de este tipo de úlcera(AU)

Introduction: Diabetic foot ulcers are the most frequent complications in people with diabetes. Different forms of treatment for this disease are known, with more or less effectiveness; but they do not solve the problem in all cases. The electrical stimulator Stimul W® and the drug Heberprot-P® have been used independently, and with satisfactory outcomes, as alternatives for the treatment of these lesions. Checking whether the combined action of both procedures allows to achieve better outcomes would contribute to solve a problem of high worldwide prevalence. Objective: To present the outcomes of applying the combination of the stimulator Stimul W® and the drug Heberprot-P® for treating a patient with diabetic foot ulcer. Case presentation: A 69-year-old male patient, with type 2 diabetes mellitus, who presented with a diabetic foot ulcer on the outside of the right foot, with abundant necrotic tissue in the form of a fistula at the base of the two remaining toes and lack of granulation. The previous treatments did not permit the expected outcomes. It was decided, as a healing therapy, to apply the combination of the stimulator Stimul W® and the drug Heberprot-P® for twelve sessions. Conclusions: Healing of the lesion was achieved by obtaining 100 percent granulation tissue and a significant reduction in its dimensions, which showed that the applied therapy constitutes an alternative for the treatment of this type of ulcer(AU)

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Poly-3-hydroxybutyrate (P3HB) is a biopolymer, which presents characteristics similar to those of plastics derived from the petrochemical industry. The thermomechanical properties and biodegradability of P3HB are influenced by its molecular weight (MW). The aim of the present study was to evaluate the changes of the molecular weight of P3HB as a function of oxygen transfer rate (OTR) in the cultures using two strains of Azotobacter vinelandii, a wild-type strain OP, and PhbZ1 mutant with a P3HB depolymerase inactivated. Both strains were grown in a bioreactor under different OTR conditions. An inverse relationship was found between the average molecular weight of P3HB and the OTRmax, obtaining a polymer with a maximal MW (8000-10,000 kDa) from the cultures developed at OTRmax of 5 mmol L-1 h-1 using both strains, with respect to the cultures conducted at 8 and 11 mmol L-1 h-1, which produced a P3HB between 4000 and 5000 kDa. The increase in MW of P3HB was related to the activity of enzymes involved in the synthesis and depolymerization. Overall, our results show that it is possible to modulate the average molecular weight of P3HB by manipulating oxygen transfer conditions with both strains (OP and PhbZ1 mutant) of A. vinelandii.

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The Chelonid herpesvirus 5 (ChHV5) is the primary etiological agent associated with fibropapillomatosis (FP), a neoplastic disease in marine turtles. In this study, we report for the first time ChHV5 in marine turtles and a leech from Baja California Peninsula. Eighty-seven black, olive or loggerhead turtle species, one FP tumor and five leeches were analyzed. The tumor sample from an olive, a skin sample from a black and a leech resulted positive of ChHV5 for conventional PCR. Two viral variants were identified and grouped within the Eastern Pacific phylogenetic group, suggesting a possible flow of the virus in this region.

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Objective: The aim of this study was to present a valve-in-valve (ViV) case and a step-by-step guideline on how to perform this procedure. Methods: A 51-year-old female with a history of rheumatic heart disease and tricuspid valve replacement presented functional class deterioration, a transesophageal echocardiogram (TEE) revealed prosthetic dysfunction due to thrombosis; therefore, a valvular replacement with a 27 mm bioprosthesis (Carpentier-Edwards Perimount) was performed without complication. 3 years after the procedure, the patients presented functional class deterioration (NYHA-III) with tricuspid dysfunction by TEE and the heart team decided to perform a transcatheter tricuspid ViV replacement.

Objetivo: El objetivo de este artículo es presentar un caso clínico de un paciente en el cual se realizó el procedimiento valve-in-valve (ViV) en la válvula tricúspide junto con una guía de cómo llevar a cabo este procedimiento paso a paso. Metodología: Paciente femenino de 51 años de edad con antecedente de Cardiopatía Reumática presenta deterioro en clase funcional encontrándose por ecocardiografía transesofágica (ETE) disfunción de válvula protésica tricúspide secundario a trombosis, se realiza recambio valvular con prótesis biológica 27 mm (Carpentier Edwards Perimount) sin complicación. 3 años después, presenta deterioro de la clase funcional (NYHA-III) y se evidencia en ETE disfunción protésica tricúspide por lo cual se decide realizar un reemplazo ViV tricúspide transcatéter.

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Objective: The aim of this study was to present a valve-in-valve (ViV) case and a step-by-step guideline on how to perform this procedure. Methods: A 51-year-old female with a history of rheumatic heart disease and tricuspid valve replacement presented functional class deterioration, a transesophageal echocardiogram (TEE) revealed prosthetic dysfunction due to thrombosis; therefore, a valvular replacement with a 27 mm bioprosthesis (Carpentier-Edwards Perimount) was performed without complication. 3 years after the procedure, the patients presented functional class deterioration (NYHA-III) with tricuspid dysfunction by TEE and the heart team decided to perform a transcatheter tricuspid ViV replacement.

Objetivo: El objetivo de este artículo es presentar un caso clínico de un paciente en el cual se realizó el procedimiento valve-in-valve (ViV) en la válvula tricúspide junto con una guía de cómo llevar a cabo este procedimiento paso a paso. Metodología: Paciente femenino de 51 años de edad con antecedente de Cardiopatía Reumática presenta deterioro en clase funcional encontrándose por ecocardiografía transesofágica (ETE) disfunción de válvula protésica tricúspide secundario a trombosis, se realiza recambio valvular con prótesis biológica 27 mm (Carpentier Edwards Perimount) sin complicación. 3 años después, presenta deterioro de la clase funcional (NYHA-III) y se evidencia en ETE disfunción protésica tricúspide por lo cual se decide realizar un reemplazo ViV tricúspide transcatéter.

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Abstract Objective: The aim of this study was to present a valve-in-valve (ViV) case and a step-by-step guideline on how to perform this procedure. Methods: A 51-year-old female with a history of rheumatic heart disease and tricuspid valve replacement presented functional class deterioration, a transesophageal echocardiogram (TEE) revealed prosthetic dysfunction due to thrombosis; therefore, a valvular replacement with a 27 mm bioprosthesis (Carpentier-Edwards Perimount) was performed without complication. 3 years after the procedure, the patients presented functional class deterioration (NYHA-III) with tricuspid dysfunction by TEE and the heart team decided to perform a transcatheter tricuspid ViV replacement.

Resumen Objetivo: El objetivo de este artículo es presentar un caso clínico de un paciente en el cual se realizó el procedimiento valve-in-valve (ViV) en la válvula tricúspide junto con una guía de cómo llevar a cabo este procedimiento paso a paso. Metodología: Paciente femenino de 51 años de edad con antecedente de Cardiopatía Reumática presenta deterioro en clase funcional encontrándose por ecocardiografía transesofágica (ETE) disfunción de válvula protésica tricúspide secundario a trombosis, se realiza recambio valvular con prótesis biológica 27 mm (Carpentier Edwards Perimount) sin complicación. 3 años después, presenta deterioro de la clase funcional (NYHA-III) y se evidencia en ETE disfunción protésica tricúspide por lo cual se decide realizar un reemplazo ViV tricúspide transcatéter.

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La literatura caribeña, por filiación histórico - cultural, pertenece a y es fiel exponente de la cultura latinoamericana. Su literariedad se ha construido sobre la base de un discurso identitario de defensa de su cultura única y, a la vez plural, que la distingue de los referentes occidentales preestablecidos por los centros de poder socioeconómico. El siguiente trabajo muestra los momentos y fases fundamentales de la evolución y desarrollo de la expresión identitaria caribeña a través de una selección cuidadosa de ejemplos de su discurso literario, con vistas a promover una cabal comprensión de los valores extra literarios de esta literatura. Puesto que este discurso literario se alza sobre un supuesto ideoestético de profunda raigambre ontológica, aproximarse a él presupone penetrar en la esencia de la historia y del patrimonio cultural de esta área. Por ello, dado el valor de este tema, se recomienda su estudio por la importancia que tiene para la formación sociocultural de los docentes cubanos, especialmente aquellos que laboran en entornos multiculturales.

Due to historical and cultural filiations, the Caribbean literature is part and a true example of the Latin American culture. Its literary particularities are based on an identity discourse, which defends a unique and, at the same time, plural culture that distinguishes it from western referents pre-established by socioeconomic power centers. This paper presents the fundamental evolution and development phases of the Caribbean identity expression. Some examples of this literary discourse were carefully selected to further an accurate understanding of its extra literary values. Since this literary discourse is based on an aesthetic ideal of deeply ontological roots, an approach to it means penetrating the essence of the region’s history and cultural patrimony. The study of the topic is important to form Cuban professors socioculturally, particularly those who work in multicultural environments.

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BACKGROUND: The overall situation in Guatemala, Central America, regarding programs caring for women's reproductive health has been lagging behind for some decades. Since the year 2000, 56% of Guatemalan families have lived below the poverty line. Guatemala has one of the highest fertility rates (lifetime births per woman) in Latin America and the Caribbean countries, comparable to those observed in less developed countries in Africa. Considering the lack of sex education, poor access to effective contraceptive methods and issues of unwanted pregnancy, Guatemalan women engage in illegal and unsafe abortions, which often causes harm and sometimes death. A key strategy designed to improve women's health is through free and informed access to contraceptive methods that are effective and accepted by Guatemalan women. STUDY DESIGN: From July 1, 2003, to December 31, 2006, specially hired trained facilitators visited 22 public hospitals for 1 week to train corresponding physician staff in postabortion counseling, enabling them to assist patients to select and use an effective contraceptive method. To monitor the progress achieved, the trained facilitators returned 4 weeks later. The main purpose of the training was to focus in strengthening the understanding and technical capacity of the hospital staff to implement postabortion contraceptive counseling and to enable women to obtain an effective contraceptive method prior to hospital discharge. RESULTS: Out of 22 hospitals, 21 managed to improve their record for counseling patients admitted for postabortion complications, from 31% to 96%. Furthermore, the percentage of women being discharged from the hospital with an effective contraceptive method rose from 20% to 64% from 2003 to 2006. CONCLUSION: The successful results obtained during this study to meet postabortion demands by Guatemalan women point out to the urgent need for the government to expand this initiative within the national health system, including health centers nationwide. This is one of the worldwide recommendations previously made by the World Health Organization.

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La competencia comunicativa surge como uno de los elementos constitutivos de la competencia profesional. Su definición ha variado a través de los años, lo que ha traído aparejado el surgimiento de diversas escuelas y tendencias en diferentes países. Disímiles son las áreas del saber que han analizado la competencia comunicativa. El siguiente trabajo presenta un desglose cronológico del surgimiento, evolución y desarrollo de dicho concepto, a partir de algunas de las figuras más representativas dentro de este campo. Dada la importancia que la misma posee, no solo para la enseñanza de idiomas sino para otras disciplinas que se nutren de los postulados y teorías que esta proclama, se hace necesario su estudio y profundización en aras de perfeccionar y enriquecer los contenidos y programas que conforman la carrera de Medicina y, de este modo, dar un paso de avance en los esfuerzos por graduar médicos más capaces y mejor preparados.

Communicative competence appears as a constituent element of professional competence. Its concept has varied through the years, which has brought about the emergence of different schools and trends in various countries. Communicative competence has been analyzed by dissimilar areas of science. This work presents a chronological study of the emergence, evolvement and development of the term from the ideas of the most outstanding personalities in the field. Given the relevance of the topic, not only for the teaching of foreign languages but for many other disciplines that are fuelled by the postulates and theories that it proclaims, it is necessary to study and deepen into the concept as a way to enrich and improve the contents and syllabuses which are part of the Medicine career curriculum so that a step forward is taken in the efforts to educate more capable and better prepared doctors.

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Guatemala tiene décadas de retraso en la implementación de adecuados programas que protejan la salud reproductiva de las mujeres. Enfrentadas a la terrible pobreza, el 56% de las familias guatemaltecas vivían por debajo de la línea de pobreza en el año 2000, situación que no ha cambiado y que posiblemente haya empeorado. Más aún, el 16% de las familias estaban en pobreza extrema, dicho en otras palabras, no podían ni adquirir una canasta básica de alimentos. Así también, la mujer guatemalteca, tiene una de las tasas más altas de fertilidad (número de hijos por mujer)...

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OBJETIVO: Dentro de las enfermedades cardiovasculares las que afectan las arterias coronarias, son las más frecuentes y engloban procesos que van desde la angina de pecho, Infarto Agudo del Miocardio, hasta la muerte súbita. El objetivo de este trabajo fue describir las características clínicas y epidemiológicas de estos pacientes. MÉTODOS: se realizó un estudio descriptivo, prospectivo, transversal de los 71 pacientes atendidos, con diagnóstico de Cardiopatía Isquémica en la Unidad de Cuidados Intensivos Polivalente del hospital Ciro Redondo García, en el período comprendido de Agosto 2006- Enero 2007. RESULTADOS: A partir de la revisión de historias clínicas se obtuvieron datos que fueron procesados estadísticamente. Los factores de riesgo mayormente encontrados fueron la HTA, el hábito de fumar y la Diabetes Mellitus. El mayor número de los pacientes tuvo una estadía de 5 días o menos y las complicaciones presentadas fueron arritmia, angina post infarto, fallo VI, schok cardiogénico y muerte, la mortalidad de 2,8 % representó un caso de schok cardiogénico y uno de trombo embolismopulmonar. CONCLUSIONES: esperamos que este trabajo sirva para trazar estrategias con el fin de mejorar el pronóstico y calidad de vida de los pacientes(AU)

OBJECTIVE: Within the cardiovascular diseases, those affecting the coronary arteries are the most frequent and they include processes that go from angina pectoris and acute myocardial infarction to sudden death. The objective of this paper was to describe the clinical and epidemiological characteristics of these patients. METHODS: A descriptive, prospective and cross-sectional study of the 71 patients with diagnosis of ischemic heart disease that received attention at the Polyvalent Intensive Care Unit of "Ciro Redondo" Hospital from August 2006 to January 2007, was undertaken. RESULTS: The data obtained from the medical histories were statistically processed. The commonest risk factors were arterial hypertension, smoking habit and diabetes mellitus. Most of the patients had a hospital stay of 5 or less days. The complications observed were arrhythmia, postinfarction angina, failure VI, cardiogenic shock and death. A case of cardiogenic shock and one of pulmonary thromboembolism accounted for 2.8 % of mortality. CONCLUSIONS: We hope this paper serves to lay down strategies aimed at improving the prognosis and quality of life of the patients(AU)

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El efecto de la adición de la lectina Concanavalina A al cultivo del hongo Ustilago maydis es examinado para contribuir al entendimiento de los mecanismos de reconocimiento e infección entre hongos y plantas. La cinética de crecimiento del hongo en cultivo mostró que la adición de Con A tiene un discreto efecto activador sobre las basidiosporas a partir de la 9h de incubación. Por otra parte, la unión de Con A a las basidiosporas causó diversos cambios morfológicos, agregación, múltiples ramificaciones y una incremantada capacidad de gemación. La unión de Con A a las basidiosporas fue evidencia utilizando un conjugado fluorescente de la lectina (Alexa-flúor), observándose mayor intensidad de fluorescencia en las puntas y zonas de gemación de las basidiosporas, lo que sugiere la distribución heterógena de estructuras sacarídicas (receptores) sobre la superficie de la pared celular del hongo durante el crecimiento. Los efectos de la adición de Con A en el cultivo del hongo se inhiben al incubar previamente la lectina con &-manopiranosa.

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Se analiza la estrategia terapéutica actual en el diabético insulinodependiente. Se insiste en la necesidad de lograr la normoglicemia como criterio de control metabólico expresado en valores normales de hemoglobina glicolisada o Hb Alc trimestral. Se debe enfatizar en la educación diabetológica reforzándola en cada consulta y reevaluando cada cierto tiempo. El cumplimiento de la dieta es fundamental. Debemos utilizar insulina altamente purificada con esquemas insulínicos principalmente basados en mezclas de insulinas o regímenes de múltiples dosis de insulina. Es necesario lograr el monitoreo glicémico por el paciente. La práctica sistemática del ejercicio físico diario o tres veces a la semana es importante. Es preciso tratar de localizar y estudiar los posibles grupos de riesgo a desarrollar esta enfermedad

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Se revisó el conocimiento actual sobre el hiperandrogenismo en niñas y adolescentes. Se consideró que existía esta afección en cualquier niña con desarrollo prematuro o excesivo de pelo púbico, acné e irregularidad menstrual. Se revisó el concepto de la unidad pilosebácea y se insistió en los ciclos del crecimiento del vello humano, en los aspectos fisiológicos de los andrógenos de la mujer. Se señaló que la testosterona, la androstendiona, la dehidroepiandrosterona y sus sulfatos son andrógenos fundamentales. Se revisaron las causas más frecuentes del hiperandrogenismo en la niña (adrenarquía prematura) y en la adolescente (síndrome de ovarios poliquísticos). Finalmente, se evaluaron los diferentes tratamientos médicos en el hirsutismo. Se concluyó que era necesario evaluar integralmente a estas pacientes, y que el tratamiento causal va dirigido a disminuir los niveles de andrógenos o inhibir la acción de éstos al nivel del folículo piloso

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BSe realiza un análisis del grado de infección por Streptococcus mutans utilizando la técnica de Matsukubo y el 60 % presentaba una elevada infección; el grado de infección y su distribución por grupos de edades y sexo son elementos que al relacionarse con la existencia de caries, permiten conocer la eficacia de las acciones preventivas en dicha área, lo que favorece la identificación de los riesgos y de los procedimientos adecuados para la evaluación del programa

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