RESUMO
OBJECTIVE: To examine genomic, social, and clinical risk factors of ≥85 weight for length percentile (WFLP) at 12 months. STUDY DESIGN: Children in this study had whole-genome sequencing, and clinical and social data were collected. WFLPs at 12 months of age were grouped as follows: (1) <85th, (2) ≥85th to <95th, (3) ≥95th to <99th, and (4) ≥99th. Whole-genome sequencing data were used to analyze rare and common variants, and association of clinical and social factors was examined. RESULTS: A total of 690 children were included; WFLPs were 422 (61.2%) <85th, 112 (16.2%) ≥85th-<95th, 89 (12.9%) ≥95th-<99th, and 67 (9.7%) ≥99th. Family-related risk factors associated with greater WFLP were greater paternal body mass index, WFLP ≥99th OR 1.10 (1.03-1.16), and greater than recommended weight gain in pregnancy, WFLP ≥85th-<95th OR 1.90 (1.09-3.26). More breast milk at 6 months was protective factor: WFLP ≥85th-<95th, OR 0.98 (0.97-0.99), WFLP ≥95th-<99th OR 0.98 (0.97-0.99), and WFLP ≥99th OR 0.98 (0.96-0.99). Although none of the variants reached genome-wide significance, there was a trend toward increased prevalence of genetic variants within or near genes previously associated with obesity in children with WFLP ≥99th. CONCLUSION: This cross-sectional study identified several modifiable factors, including increased weight gain in pregnancy and decreased breast milk at 6 months, associated with greater WFLP at 12 months. Strong genetic factors were not identified.
Assuntos
Predisposição Genética para Doença , Obesidade Infantil/genética , Fatores de Risco , Alelos , Estatura , Índice de Massa Corporal , Estudos Transversais , Feminino , Frequência do Gene , Variação Genética , Humanos , Lactente , Masculino , Leite Humano , Gravidez , Controle de Qualidade , Análise de Sequência de DNA , Aumento de PesoRESUMO
OBJECTIVE: This study investigated the association between alcohol and violence among Argentine youth. METHODS: Data from the 2007 Argentina Global School-based Student Health Survey (GSHS), a nationally representative survey of middle school students, were examined using age-adjusted logistic regression models. RESULTS: Of the 1,328 participating students aged 13 to 15 years old, 51.9% reported drinking alcohol in the previous month, with higher rates among males (p=0.04) and older students (p<0.01). Both male and female drinkers were nearly twice as likely as non-drinkers to report being physically attacked, being in a physical fight, and having thoughts about self-directed violence. Among drinkers, those who reported poor mental health, were victims of bullying, used tobacco or drugs, or skipped school without permission were approximately twice as likely as other drinkers to have engaged in violent activities. CONCLUSION: Public health interventions targeting violence among young adolescents should be developed in combination with alcohol education programs.
Assuntos
Comportamento do Adolescente/psicologia , Consumo de Bebidas Alcoólicas/epidemiologia , Vigilância da População/métodos , Violência/estatística & dados numéricos , Adolescente , Consumo de Bebidas Alcoólicas/psicologia , Argentina/epidemiologia , Bullying , Estudos Transversais , Feminino , Humanos , Masculino , Saúde Mental/estatística & dados numéricos , Prevalência , Comportamento Autodestrutivo/complicações , Distribuição por Sexo , Fatores Sexuais , Violência/psicologiaRESUMO
OBJETIVO: Este estudo investigou a associação entre álcool e violência na população de jovens argentinos. MÉTODOS: Dados da Global School-based Student Health Survey (GSHS) de 2007, uma pesquisa representativa em termos nacionais com alunos do ensino médio, foram examinados utilizando-se modelos de regressão logística ajustados por idade. RESULTADOS: Dos 1328 alunos participantes entre 13 e 15 anos de idade, 51,9% declararam ter consumido álcool no último mês, com taxas mais elevadas entre meninos (p = 0,04) e alunos mais velhos (p < 0,01). Homens e mulheres que bebem demonstraram estar quase duas vezes mais propensos a relatar agressão física, quando em uma briga física, e pensamentos sobre violência autoinfligida do que aqueles que não bebem. Entre as pessoas que bebem, aquelas que reportaram saúde mental precária, haviam sido vítimas de bullying, fumavam, faziam uso de drogas ou abandonaram a escola sem permissão se mostraram duas vezes mais propensas ao envolvimento em atividades violentas do que outras pessoas que também bebem. CONCLUSÃO: Intervenções de saúde pública quanto à violência entre jovens adolescentes devem ser desenvolvidas em combinação com programas de educação sobre álcool.
OBJECTIVE: This study investigated the association between alcohol and violence among Argentine youth. METHODS: Data from the 2007 Argentina Global School-based Student Health Survey (GSHS), a nationally representative survey of middle school students, were examined using age-adjusted logistic regression models. RESULTS: Of the 1,328 participating students aged 13 to 15 years old, 51.9% reported drinking alcohol in the previous month, with higher rates among males (p = 0.04) and older students (p < 0.01). Both male and female drinkers were nearly twice as likely as non-drinkers to report being physically attacked, being in a physical fight, and having thoughts about self-directed violence. Among drinkers, those who reported poor mental health, were victims of bullying, used tobacco or drugs, or skipped school without permission were approximately twice as likely as other drinkers to have engaged in violent activities. CONCLUSION: Public health interventions targeting violence among young adolescents should be developed in combination with alcohol education programs.