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PURPOSE: The purpose of this study is to characterize the phonological skills of low-income preschool children in a city in the Natal in the Northeast, Brazil. METHODS: The researchers assessed the phonological skills of 90 children (from 5 to 6:11) in early childhood education in three public schools located in regions of social and economic vulnerability. The evaluators used the phonology subtests of the Test of Childhood language (ABFW) children's language test. In addition to performing the standard analysis they examined the following: Phonological Processes (PP), Percentage of Correct Consonants (PCC), Percentage of Correct Consonants Revised (PCC-R), and Process Density Index (PDI). The Spearman's Correlation Coefficient test was used to analyze for correlations among the PCC, PCC-R, and PDI. RESULTS: According to the cutoff values of children who speak Brazilian Portuguese (BP), adequacy of the PCC and PCC-R values was observed in most participants (PCC: 82 children - 91.1%; PCC-R: 87 children - 94.6%). The processes of liquid simplification (LS), consonant clusters simplification (CCS), final consonant simplification (FCS) were productive of which the CCS (32.2%) and FCS (20%) are still expected for age and LS are not. There was a robust negative correlation between the variables PCC x PDI and PCC-R x PDI. CONCLUSION: Most children showed adequate phonological development. Variations were observed in syllabic segments, especially in the coda, which reflect the influence of regional linguistic differences. The evidence obtained regarding the phonological performance of children within this region contributes to a more accurate speech-language diagnosis.

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RESUMO

ABSTRACT Purpose The purpose of this study is to characterize the phonological skills of low-income preschool children in a city in the Natal in the Northeast, Brazil. Methods The researchers assessed the phonological skills of 90 children (from 5 to 6:11) in early childhood education in three public schools located in regions of social and economic vulnerability. The evaluators used the phonology subtests of the Test of Childhood language (ABFW) children's language test. In addition to performing the standard analysis they examined the following: Phonological Processes (PP), Percentage of Correct Consonants (PCC), Percentage of Correct Consonants Revised (PCC-R), and Process Density Index (PDI). The Spearman's Correlation Coefficient test was used to analyze for correlations among the PCC, PCC-R, and PDI. Results According to the cutoff values of children who speak Brazilian Portuguese (BP), adequacy of the PCC and PCC-R values was observed in most participants (PCC: 82 children - 91.1%; PCC-R: 87 children - 94.6%). The processes of liquid simplification (LS), consonant clusters simplification (CCS), final consonant simplification (FCS) were productive of which the CCS (32.2%) and FCS (20%) are still expected for age and LS are not. There was a robust negative correlation between the variables PCC x PDI and PCC-R x PDI. Conclusion Most children showed adequate phonological development. Variations were observed in syllabic segments, especially in the coda, which reflect the influence of regional linguistic differences. The evidence obtained regarding the phonological performance of children within this region contributes to a more accurate speech-language diagnosis.

RESUMO Objetivo Caracterizar o sistema fonológico de crianças pré-escolares de baixa renda da cidade de Natal, Nordeste do Brasil. Método Foi analisado o nível fonológico de 90 crianças da educação infantil de três escolas públicas localizadas em regiões de vulnerabilidade social. Foi utilizado o instrumento ABFW, nomeação e imitação, por meio da análise tradicional e das medidas de Porcentagem de Consoantes Corretas (PCC), Porcentagem de Consoantes Corretas Revisado (PCC-R) e Índice de Ocorrência de Processos (PDI). Para análise estatística inferencial foi utilizado o teste do Coeficiente de Correlação de Spearman para analisar a correlação entre as variáveis PCC, PCC-R e PDI. Resultados De acordo com os valores de corte das crianças que falam Português Brasileiro (PB), a adequação dos valores da PCC e PCC-R foi observada na maioria dos participantes (PCC: 82 crianças - 91,1%; PCC R: 87 crianças - 94,6%). Os processos de simplificação de líquidas (SL), simplificação de encontros consonantais (SEC), simplificação de consoante final (SCF) foram produtivos dos quais o CCS (32,2%) e FCS (20%) ainda são esperados para a idade e SL não. Houve correlação negativa muito forte entre as variáveis PCC x PDI e PCC-R x PDI. Conclusão A maioria das crianças apresentou desenvolvimento fonológico adequado. Foram observadas variações nos segmentos silábicos, principalmente na coda, que refletem a influência das diferenças linguísticas regionais. As evidências obtidas sobre o desempenho fonológico das crianças dessa região contribuem para um diagnóstico fonoaudiológico mais preciso.

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Aqueous two-phase systems (ATPS) have emerged as an alternative strategy for the recovery and purification of a wide variety of biological products. Typical process development requires a large screening of experimental conditions towards industrial adoption where continuous processes are preferred. In this work, it was proved that under certain flow conditions, ATPS could be formed continuously inside a microchannel, starting from stocks of phase components. Staggered herringbone chaotic micromixers included within the device sequentially and rapidly prepare two-phase systems across an entire range of useful phase compositions. Two-phase diagrams (binodal curves) were easily plotted using the cloud-point method for systems of different components and compared with previously reported curves for each system, proving that phase formation inside the device correlated with the previously reported diagrams. A proof of concept for sample partitioning in such a microdevice was performed with two different experimental models: BSA and red blood cells. Finally, the microdevice was employed to obtain information about the recovery and partition coefficient of invertase from a real complex mixture of proteins (yeast extract) to design a process for the recovery of the enzyme selecting a suitable system and composition to perform the process at bench-scale.

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