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2.
Cancer Res ; 43(8): 3892-9, 1983 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-6602653

RESUMO

To determine whether the human T-cell lymphoma-leukemia virus (HTLV) is associated with particular cancers, patient sera were surveyed for HTLV-specific antibodies. An association was seen with aggressive cancers of mature T-cells, specifically Japanese adult T-cell leukemia (ATL) and T-cell lymphosarcoma cell leukemia (TLCL), a similar cancer of Caribbean blacks. Ninety to 100% of these patients possessed HTLV-specific antibody. Forty-seven and 20% of relatives of ATL and TLCL patients, respectively, and 12 and 4% of healthy donors from ATL and TLCL endemic areas were also antibody positive. Visceral organ involvement, hypercalcemia, and skin manifestation, features of ATL and TLCL, were often seen in other antibody-positive patients. Childhood cancers, most cutaneous T-cell and all non-T-cell leukemias and lymphomas, myeloid leukemias, Hodgkin's disease, and solid tumors were not associated with HTLV. Healthy United States donors and European patients with non-malignant diseases were antibody negative. HTLV is thus associated with a subtype of adult T-cell leukemia-lymphoma, clustered in viral endemic areas, with apparent racial and geographic predilection.


Assuntos
Linfoma/microbiologia , Retroviridae/análise , Linfócitos T , Adulto , Idoso , Anticorpos Antivirais/análise , Feminino , Humanos , Japão/etnologia , Leucemia/epidemiologia , Linfoma/imunologia , Masculino , Pessoa de Meia-Idade , Retroviridae/imunologia , Índias Ocidentais/etnologia
3.
Proc Natl Acad Sci U S A ; 80(12): 3812-5, 1983 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-6304740

RESUMO

DNA from one biopsy sample of invasive cancer of the cervix contained sequences hybridizing with human papillomavirus (HPV) type 11 DNA only under nonstringent conditions. This DNA was molecularly cloned in lambda phage. Under stringent conditions of hybridization it cross-hybridized to a minor extent (less than 0.1%) with HPV types 10, 14, and 15 and showed no homology with DNA of other human HPV types. We therefore propose to designate it tentatively as HPV 16. HPV 16 DNA was used as a probe to test additional cancer biopsy samples from cervical, vulval, and penile cancer, as well as benign genital warts (condylomata acuminata) and cervical dysplasias for the presence of homologous sequences. In 61.1% (11/18) of cervical cancer samples from German patients sequences were found hybridizing with HPV 16 DNA under conditions of high stringency. In contrast, only 34.8% (8/23) of cancer biopsy samples from Kenya and Brazil revealed this DNA. Vulval and penile cancer biopsy samples hybridized to 28.6% (2/7) or 25% (1/4), respectively. Only 2 out of 33 condylomata acuminata contained HPV 16 DNA. Both positive tumors harbored in addition HPV 6 or HPV 11 DNA. The data thus indicate that HPV 16 DNA prevails in malignant tumors, rendering an accidental contamination with papillomavirus DNA from adjacent papillomas rather unlikely. The rare presence in benign genital papillomas in addition to common genital papillomaviruses suggests a dependence of HPV 16 replication on helper virus.


Assuntos
DNA Viral/genética , Papillomaviridae/isolamento & purificação , Neoplasias do Colo do Útero/microbiologia , Bacteriófago lambda/genética , Brasil , Clonagem Molecular , DNA Viral/isolamento & purificação , Feminino , Alemanha Ocidental , Humanos , Quênia , Hibridização de Ácido Nucleico , Papillomaviridae/genética
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