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J Pediatr ; 143(5): 582-6, 2003 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-14615726

RESUMO

OBJECTIVES: To test whether iron supplementation affects hematologic, biochemical, and developmental status in term breast-fed infants. STUDY DESIGN: Term breast-fed infants (n=77) were randomly selected to receive either 7.5 mg per day of elemental iron as ferrous sulfate or placebo from 1 to 6 months of age. Investigators and families were unaware of group assignment. Complete blood count and ferritin, red cell superoxide dismutase, catalase, plasma ferric reducing antioxidant power, and zinc and copper levels were analyzed at 1, 3.5, 6, and 12 months of age. Bayley mental and psychomotor developmental indexes (MDI and PDI) and visual acuity (with the use of Teller acuity cards) were assessed from 12 to 18 months of age. Analysis performed by analysis of variance and t tests was by intention to treat. RESULTS: Iron supplementation resulted in higher hemoglobin and mean corpuscular volume at 6 months of age and significantly higher visual acuity and PDI at 13 months of age (100+/-12 vs 93+/-9 [+/-SD]). Treatment and placebo groups did not differ in anthropometric indexes, compliance, biochemical status, or demographic characteristics. CONCLUSIONS: Iron supplementation of breast-fed infants appears safe and might have beneficial hematologic and developmental effects for some infants.


Assuntos
Aleitamento Materno , Suplementos Nutricionais , Fenômenos Fisiológicos da Nutrição do Lactente , Ferro/administração & dosagem , Anemia Ferropriva/epidemiologia , Anemia Ferropriva/prevenção & controle , Peso Corporal , Aleitamento Materno/estatística & dados numéricos , Catalase/sangue , Cognição/efeitos dos fármacos , Cobre/sangue , Método Duplo-Cego , Feminino , Ferritinas/sangue , Humanos , Lactente , Recém-Nascido , Ferro/farmacologia , Masculino , Destreza Motora/efeitos dos fármacos , Desempenho Psicomotor/efeitos dos fármacos , Superóxido Dismutase/sangue , Acuidade Visual/efeitos dos fármacos , Zinco/sangue
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