RESUMO

We report the discovery of two enteroviruses detected in nasopharyngeal samples obtained from subjects with respiratory disease in Peru. Phylogenetic analysis indicated that both viruses belong to a clade within the species Human enterovirus C, which includes the recently characterized human enteroviruses 109 and 104. Members of this clade have undergone significant genomic rearrangement, as indicated by deletions in the hypervariable region of the 5' UTR and the VP1 protein, as well as recombination within the non-structural genes. Our findings and review of published sequences suggests that several novel human enterovirus C serotypes are currently circulating worldwide.

Assuntos

Enterovirus Humano C/genética , Infecções por Enterovirus/virologia , Genoma Viral , Sistema Respiratório/virologia , Doenças Respiratórias/virologia , Regiões 5' não Traduzidas , Sequência de Aminoácidos , Sequência de Bases , Estudos de Coortes , Genômica/métodos , Genótipo , Humanos , Dados de Sequência Molecular , Peru , Filogenia , Proteínas não Estruturais Virais