RESUMO
Abstract Recently, gut microbiota has emerged as an important mediator of several diseases such as diabetes, atherosclerosis, arterial hypertension, obesity, cancers and neuropsychiatric diseases including Alzheimer, autism and depression. Intestinal microbiota is formed by bacteria, fungi and viruses and its main function is to facilitate the absorption and metabolism of foods (protein, fat and carbohydrate). One example of the multiple actions of the gut microbiota is the bidirectional relationship between the intestine and the brain, the so-called "gut/brain axis". Furthermore, metabolites produced by gut microbiota can induce effects locally or at distance, which suggests that the intestine is an endocrine organ. Given the participation of the gut microbiota in several diseases, there is great interest in strategies that may positively affect the gut flora and prevent or even treat diseases. Among these strategies, lifestyle change, but specially diet modulation has gained importance. In this article, we review the mechanisms through which intestinal microbiota participates in cardiovascular diseases and possible therapeutic interventions.
Assuntos
Doenças Cardiovasculares/dietoterapia , Doenças Cardiovasculares/prevenção & controle , Microbioma Gastrointestinal/fisiologia , Doenças Cardiovasculares/etiologia , Dieta Mediterrânea , Fatores de Risco de Doenças Cardíacas , Eixo Encéfalo-IntestinoRESUMO
O transplante de órgãos permite que indivíduos seriamente incapacitados ou com a vida em risco possam conduzi-la de forma mais funcionale confortável...