RESUMO
Neurocysticercosis (NCC) is a common central nervous system (CNS) infection caused by Taenia solium metacestodes. Depression is present in 53-85% of the NCC patients. The present study was aimed to evaluate the correlation of signs of NCC activity (evolution phase of NCC cysts and CSF characteristics) with depression. The study group consisted of 65 patients subdivided into two groups: NCC with epilepsy (48) and NCC without epilepsy [17]. Depression was assessed and quantified by the Hamilton Rating Scale for Depression (HRSD-21) and compared with CSF inflammatory characteristics (increase of WBCs and total protein) and presence of calcifications or cysts. There was no difference between the scores of depression in the group with CNS calcifications or cysts. CSF signs of active disease, specifically increase of CSF TP, were significantly more frequent in patients with mild depression and in non-depressant patients. The depression scores were inversely proportional to the CSF TP levels in the groups with depression. Although immunological factors could be associated with the development of depression, the data above lead us to make assumptions about the association of other factors such as genetic predisposition, or social and cultural factors.
Assuntos
Cistos/complicações , Depressão/etiologia , Neurocisticercose/complicações , Proteínas do Líquido Cefalorraquidiano/análise , Cistos/líquido cefalorraquidiano , Depressão/líquido cefalorraquidiano , Epilepsia/complicações , Feminino , Humanos , Contagem de Leucócitos , Masculino , Neurocisticercose/líquido cefalorraquidiano , Escalas de Graduação PsiquiátricaRESUMO
Objective of this study to investigate the impact of NCC upon the quality of life (QoL) compared to other chronic neurological diseases, epilepsy and headache. The study group consisted of 114 patients subdivided into four groups: NCC with epilepsy (n = 48), NCC without epilepsy (n = 17), epilepsy without NCC (n = 25) and chronic headache (n = 24). The QoL was evaluated by direct subjective quantification (scale of 0-10) and FACT-HN IV. NCC had impact on QoL, 53.8% patients dependent and needing help. The impact on QoL did not correlate with the classification of NCC, presence of cysts or calcifications and with CSF TP or number of WBCs. The presence of depression had a significant impact on the QoL of patients with NCC. Lack of seizure control tended to produce an adverse effect on the QoL in the group of NCC and epilepsy. NCC is not a benign disease; it has greater adverse effects on QoL of patients than epilepsy and headache, although without statistical significance. The presence of depression and uncontrolled seizures may have impact on QoL. Since asymptomatic patients were not evaluated, the results of this study are not applicable to all individuals with NCC.
Assuntos
Atitude Frente a Saúde , Neurocisticercose/complicações , Neurocisticercose/psicologia , Qualidade de Vida/psicologia , Adulto , Depressão/complicações , Depressão/psicologia , Feminino , Transtornos da Cefaleia/complicações , Transtornos da Cefaleia/psicologia , Humanos , Masculino , Pessoa de Meia-Idade , Convulsões/complicações , Convulsões/psicologia , Autoavaliação (Psicologia) , Índice de Gravidade de Doença , Adulto JovemRESUMO
UNLABELLED: Neurocysticercosis (NCC) is a common central nervous system infection caused by Taenia solium metacestodes. OBJECTIVE: To investigate the occurrence of depression in patients with calcified NCC form. The study group consisted of 114 patients subdivided in four groups: NCC with epilepsy, NCC without epilepsy, epilepsy without NCC and chronic headache. METHOD: Depression was evaluated and quantified by the Hamilton Rating Scale for Depression (HRSD-21). RESULTS: Percentage of patients with depression was as follows: group 1 (83%); group 2 (88%); group 3 (92%); group 4 (100%). The majority of patients had moderate depression. CONCLUSION: Incidence of depression in all groups was higher than in the general population. It is possible that, in a general way, patients with chronic diseases would have depression with similar intensity. NCC is associated with the presence of depression.
Assuntos
Depressão/etiologia , Epilepsia/etiologia , Neurocisticercose/psicologia , Estudos de Casos e Controles , Doença Crônica , Feminino , Humanos , Masculino , Escalas de Graduação PsiquiátricaRESUMO
Neurocysticercosis (NCC) is a common central nervous system infection caused by Taenia solium metacestodes. Objective: To investigate the occurrence of depression in patients with calcified NCC form. The study group consisted of 114 patients subdivided in four groups: NCC with epilepsy, NCC without epilepsy, epilepsy without NCC and chronic headache. Method: Depression was evaluated and quantified by the Hamilton Rating Scale for Depression (HRSD-21). Results: Percentage of patients with depression was as follows: group 1 (83 percent); group 2 (88 percent); group 3 (92 percent); group 4 (100 percent). The majority of patients had moderate depression. Conclusion: Incidence of depression in all groups was higher than in the general population. It is possible that, in a general way, patients with chronic diseases would have depression with similar intensity. NCC is associated with the presence of depression.
Neurocysticercose (NCC) é uma infecção do sistema nervoso central comum causada por metacestodes da Taenia solium. Objetivo: investigar a ocorrência de depressão nos pacientes com NCC forma calcificada. O grupo de estudo é formado por 114 pacientes subdivididos em quatro grupos: NCC com epilepsia, NCC sem epilepsia, epilepsia sem NCC e cefaléia crônica. Método: A presença de depressão foi determinada e quantificada pela Escala de Depressão de Hamilton (HRSD-21). Resultados: A porcentagem de pacientes com depressão foi: grupo 1 (83 por cento); grupo 2 (88 por cento); grupo 3 (92 por cento); grupo 4 (100 por cento). A maioria dos pacientes apresentou depressão moderada. Conclusão: A incidência da depressão em todos os grupos foi mais elevada do que na população geral, contudo não houve diferença entre os grupos estudados. É possível que, de uma maneira geral, os pacientes portadores de doença crônica apresentarem a depressão em intensidade similar. NCC está associada com a presença de depressão.