1.
Org Biomol Chem
; 18(37): 7330-7335, 2020 09 30.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32946540
RESUMO
The controlled mono-addition of indolizines to isatins under very mild conditions is described. The reaction occurs in water using diphenylphosphate as the catalyst, which is dramatically accelerated by surfactant addition. 3-Hydroxy-3-indolizinyl-2-oxindole scaffolds were synthesized in up to >99% yield. Notably, in organic solvents only bis-addition products were observed.