RESUMO
This study was conducted in normotensive and hypertensive subjects at the Vargas Hospital of Caracas. Normotensive subjects received, in a cross-over fashion, placebo, metoclopramide (MTC), or domperidone (DOMP), 40 mg of each drug, daily for 1 week. The first group of patients under placebo for 1 week received a single 2.5-mg oral dose of bromocriptine (Br). The second group of patients received 30 mg MTC daily (divided into three doses) for 1 week. At the end of the period a single dose of 2.5 mg Br was administered to each patient. The third group of eight hypertensive patients received DOMP for 1 week at 30 mg/d and then a single 2.5-mg Br dose. Cardiovascular and biochemical parameters including arterial pressure, heart rate, plasma renin activity, and plasma aldosterone were evaluated during the 6-hour period before and after the administration of Br. Neither DOMP nor MTC significantly modified blood pressure and heart rate in normotensive patients. Br reduced both systolic and diastolic arterial pressure in hypertensive subjects. The peak of the antihypertensive effect appeared 3 hours after drug administration, but reduction of arterial pressure lasted approximately 6 hours. At the same time, Br reduced plasma aldosterone levels and plasma renin activity. MTC and DOMP reversed the antihypertensive effect of Br and its effect on aldosterone levels and plasma renin activity. We conclude from these findings that Br acts as an antihypertensive agent at peripheral and central levels by stimulating dopamine-2 receptors, which are involved in the aldosterone and renin secretion.
Assuntos
Anti-Hipertensivos/farmacologia , Bromocriptina/antagonistas & inibidores , Bromocriptina/farmacologia , Domperidona/farmacologia , Agonistas de Dopamina/farmacologia , Antagonistas de Dopamina/farmacologia , Hipertensão/tratamento farmacológico , Metoclopramida/farmacologia , Receptores de Dopamina D2/agonistas , Adulto , Aldosterona/sangue , Pressão Sanguínea/efeitos dos fármacos , Estudos de Casos e Controles , Estudos Cross-Over , Antagonismo de Drogas , Quimioterapia Combinada , Feminino , Humanos , Hipertensão/sangue , Hipertensão/fisiopatologia , Masculino , Pessoa de Meia-Idade , Renina/sangue , Renina/efeitos dos fármacosRESUMO
Two groups of patients with essential hypertension were studied at the Vargas Hospital of Caracas. The first group of 9 patients under placebo treatment for 1 week received a single 2.5 mg oral dose of bromocriptine. Cardiovascular and biochemical parameters including arterial pressure, heart rate, plasma renin activity, and plasma aldosterone levels were evaluated during the 6-hour period before and after the administration of drugs. The second experimental design was as follows: 9 patients received 30 mg metoclopramide daily (divided in 3 doses) for 1 week. At the end of the period a single oral dose of 2.5 mg of bromocriptine was given to each patient. The cardiovascular and biochemical parameters were also determined. Bromocriptine reduced both systolic and diastolic arterial pressure. The peak antihypertensive effect was shown 3 hours after administration of the drug, but the reduction of arterial pressure lasted approximately 6 hours. At the same time bromocriptine reduced plasma aldosterone levels and plasma renin activity. This reduction persisted 6 hours after its administration. Metoclopramide reversed the antihypertensive effect of bromocriptine and its effect on aldosterone secretion and plasma renin activity. We conclude from these findings that bromocriptine acts as an antihypertensive agent by stimulating DA2 dopaminergic receptor, the dopaminergic receptor involved in aldosterone and renin secretion is possibly DA2.
Assuntos
Anti-Hipertensivos/antagonistas & inibidores , Bromocriptina/antagonistas & inibidores , Antagonistas de Dopamina/farmacologia , Hipertensão/fisiopatologia , Metoclopramida/farmacologia , Aldosterona/sangue , Pressão Sanguínea/efeitos dos fármacos , Bromocriptina/uso terapêutico , Antagonistas dos Receptores de Dopamina D2 , Feminino , Frequência Cardíaca/efeitos dos fármacos , Humanos , Hipertensão/tratamento farmacológico , Masculino , Pessoa de Meia-Idade , Renina/sangueRESUMO
La presente investigación se llevó a cabo en un grupo de estudiantes de nivel terciario, en las instituciones que se detallan: Derecho, Económicas, Ciencias Biológicas, Educación Física, Psicología, Ciencias de la Salud, Ingenieria y Arquitectura. Este estudio es prospectivo y analitico y se efectúa mediante una encuesta con preguntas cerradas, autoadministrado y anónimo. Los objetivos planteados fueron: determinar el estado actual de los estudiantes acerca de los métodos contraceptivos, frecuencia de su uso de analizar cuales son sus fuentes habituales de información. La muestra se recolectó por cuotas de sexo en cada institución, 19 femeninas y 19 masculinas, con un total de 240 encuestas. Los resultados se analizan con respecto a las respuestas obtenidas por alumnos cursando en carreras con materias afines y no afines a biologia. Del cuestionario se destacan las respuestas obtenidas correctamente en los itens relacionados acerca de los conocimientos y fuentes de acceso a información relacioanda con los métodos contraceptivos (AU)
Assuntos
Anticoncepção , Planejamento Familiar , Educação Sexual , Inquéritos Epidemiológicos , Promoção da Saúde , EstudantesRESUMO
La presente investigación se llevó a cabo en un grupo de estudiantes de nivel terciario, en las instituciones que se detallan: Derecho, Económicas, Ciencias Biológicas, Educación Física, Psicología, Ciencias de la Salud, Ingenieria y Arquitectura. Este estudio es prospectivo y analitico y se efectúa mediante una encuesta con preguntas cerradas, autoadministrado y anónimo. Los objetivos planteados fueron: determinar el estado actual de los estudiantes acerca de los métodos contraceptivos, frecuencia de su uso de analizar cuales son sus fuentes habituales de información. La muestra se recolectó por cuotas de sexo en cada institución, 19 femeninas y 19 masculinas, con un total de 240 encuestas. Los resultados se analizan con respecto a las respuestas obtenidas por alumnos cursando en carreras con materias afines y no afines a biologia. Del cuestionario se destacan las respuestas obtenidas correctamente en los itens relacionados acerca de los conocimientos y fuentes de acceso a información relacioanda con los métodos contraceptivos