RESUMO
INTRODUCTION: To find out the changes in seminal quality of hemodialysis chronic renal patients, we investigated the possible relationship between seminal parameter and seminal α1-acid glycoprotein levels in chronic hemodialysis patients. METHODS: Prospective study of prevalence realized in the Hemodialysis Sector of the University Hospital of the University of Brasília, between July 2016 and December 2016. Men aged 18-60 years grouped into case groups (n = 81) represented by chronic hemodialysis patients and control group (n = 20) of healthy men without clinical or laboratory signs of infection and eugonadic. We performed a spermogram, hormonal profile, and assessment of leukocytes and seminal α1-acid glycoprotein level in the semen. The most appropriate statistical test was applied to verify differences and correlations between the studied variables. RESULTS: The age in case and control is similar (49.47 ± 5.55 years vs 50.53 ± 4.24 years; p = 0.060). Mean level of α1-acid glycoprotein in human seminal plasma were not significantly different between case and control (48.52 ± 4.90 mg/L vs 46.33 ± 4.29 mg/L; p = 0.10) and between normosperm and oligosperm (47.76 ± 5.15 mg/L vs 49.48 ± 4.49 mg/L; p = 0.19). Mean level of α1-acid glycoprotein in human seminal plasma in the case group, which were classified into severe, moderate, mild, and normosperm, were similar to each other (p = 0.27) and did not correlate (p > 0.05) with the analyzed seminal parameters. All participants presented normal hormonal profile. CONCLUSION: Results of this study suggest that the seminal α1-acid glycoprotein levels do not help in the initial evaluation of patients with seminal parameter changes.
Assuntos
Orosomucoide/análise , Diálise Renal , Insuficiência Renal Crônica/terapia , Sêmen/química , Adolescente , Adulto , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Adulto JovemRESUMO
BACKGROUND: We proposed to investigate the possible relationship between seminal quality and ferritin and transferrin seminal levels in chronic hemodialysis (CH) patients. MATERIALS AND METHODS: This is a cross-sectional study in a group of 60 men (case) undergoing CH for more than 6 months, and a group of 30 healthy men (control), aged 18-60 years, without clinical or laboratory signs of infection/inflammation and eugonadic. A spermogram was performed by manual method and measured the ferritn and transferrin seminal levels. RESULTS: The case and control groups were age-matched (49.47±5.56 versus 47.90±6.22, p = 0.229). Comparison between case and control group, the exception of seminal ferritin levels that were similar (p = 0.136), were significantly lower in the case group (p<0.001) for all constituents of the seminal parameter and seminal transferrin levels. Seminal ferritin does not appear to be associated with seminal parameters and seminal transferrin (p>0.05); but there was an association between seminal transferrin and seminal parameters (p<0.001). CONCLUSIONS: Our results suggest that seminal quality is related to seminal transferrin level and not with seminal ferritin level being useful in the initial evaluation of chronic hemodialysis patients with clinical suspicion of sub / infertility.