RESUMO
Background: Primary splenic torsion occurs when there is a splenic vascular pedicle rotation without association of otherdiseases, as the Gastric Dilatation Volvulus (GDV). Accessory spleen consists in a splenic tissue fraction independentfrom main organ, caused by a spleen defect in the embryonic development, most remaining asymptomatic and discoveredincidentally. They have their own blood supply, which is usually from a branch of the splenic artery. Present report represents a primary splenic torsion with the accessory spleen finding in a dog.Case: A 7-year-old female mongrel was referred to Veterinary Hospital of Universidade Federal do Rio Grande do Sul,showing pain and firm consistency in the left abdominal region, prostration and inappetence four days before the medicalappointment. At the clinical examination, the patient was alert, 7% dehydration, hypocorous mucous membranes, withoutalteration in lymph nodes, left abdominal pain. Laboratory tests, chest radiographic and abdominal ultrasound was requested.Two images compatible with splenic image were visualized, one with a regular structure without vascularization suggestingsplenic torsion and another with homogeneous parenchyma and echogenicity of the normal spleen, with vascularizationsignal. The animal was referred to the surgical procedure and the anesthetic induction protocol with propofol (6 mg/kg-1)and ketamine hydrochloride (2 mg/kg-1) and maintenance with total intravenous anesthesia with propofol (0.2-0.4 mg/kg-1/min) and lidocaine (2 mg/kg-1), in a semi-closed loop and spontaneous ventilation. The pre-retro-umbilical incision in theventral midline was performed, and the exploratory celiotomy was done. During the cavity exploring, a small amount of freefluid and a structure compatible with the spleen were observed. It was noted that the splenic vascular pedicle was twistedaround its axis and the gastroesplenic and splenocolic ligaments were also involved...(AU)
Assuntos
Animais , Cães , Anormalidade Torcional/veterinária , Baço/patologia , Baço/anormalidades , Esplenectomia/veterináriaRESUMO
Background: Primary splenic torsion occurs when there is a splenic vascular pedicle rotation without association of otherdiseases, as the Gastric Dilatation Volvulus (GDV). Accessory spleen consists in a splenic tissue fraction independentfrom main organ, caused by a spleen defect in the embryonic development, most remaining asymptomatic and discoveredincidentally. They have their own blood supply, which is usually from a branch of the splenic artery. Present report represents a primary splenic torsion with the accessory spleen finding in a dog.Case: A 7-year-old female mongrel was referred to Veterinary Hospital of Universidade Federal do Rio Grande do Sul,showing pain and firm consistency in the left abdominal region, prostration and inappetence four days before the medicalappointment. At the clinical examination, the patient was alert, 7% dehydration, hypocorous mucous membranes, withoutalteration in lymph nodes, left abdominal pain. Laboratory tests, chest radiographic and abdominal ultrasound was requested.Two images compatible with splenic image were visualized, one with a regular structure without vascularization suggestingsplenic torsion and another with homogeneous parenchyma and echogenicity of the normal spleen, with vascularizationsignal. The animal was referred to the surgical procedure and the anesthetic induction protocol with propofol (6 mg/kg-1)and ketamine hydrochloride (2 mg/kg-1) and maintenance with total intravenous anesthesia with propofol (0.2-0.4 mg/kg-1/min) and lidocaine (2 mg/kg-1), in a semi-closed loop and spontaneous ventilation. The pre-retro-umbilical incision in theventral midline was performed, and the exploratory celiotomy was done. During the cavity exploring, a small amount of freefluid and a structure compatible with the spleen were observed. It was noted that the splenic vascular pedicle was twistedaround its axis and the gastroesplenic and splenocolic ligaments were also involved...
Assuntos
Animais , Cães , Anormalidade Torcional/veterinária , Baço/anormalidades , Baço/patologia , Esplenectomia/veterináriaRESUMO
Iobitridol is a tri-iodinated contrast agent, and neurotoxicologic studies of the intracisternal administration are scarce and inconclusive. The purpose of this study was to compare the neurotoxicity of iobitridol with iohexol, by intracisternal administration in Wistar rats, for a pre-clinical evaluation of its use as a myelographic agent. The animals, a total of 75, were divided into three experimental groups, iobitridol, iohexol and cerebral artificial fluid (control group), with 25 animals per group. Then, these were divided into five subgroups of five animals each, and given doses of 200, 400, 600, 800 and 1000 mg kg-1, while the control group received the equivalent volumes of contrast media tested. The animals were evaluated after 5, 15, 30, 60, 120, 180 and 240 min of intracisternal administration of these substances, for signs of depression and excitement, tactile palmar grasp, flexor, extensor, palpebral, papillary and pinna reflexes, surface righting and placing reactions, and with an auditory startle test. The evaluations were assessed daily for seven days with these parameters and their body weight, food, and water intake were also measured. There were no statistically significant differences between groups tested with respect to any of the evaluated parameters. In other words, in this animal model, the iobitridol demonstrated a low neurotoxicologic potential, comp
O iobitridol é um meio de contraste tri-iodado, e estudos referentes à neurotoxicidade, com administração subaracnóide são escassos e inconclusivos. O objetivo deste trabalho foi comparar a neurotoxicidade do iobitridol com a do iohexol, por via intracisternal, em ratos Wistar, como avaliação pré-clínica da utilização deste como agente mielográfico. Foram utilizados 75 animais divididos em três grupos experimentais com 25 animais: iobitridol, iohexol e líquido cerebroespinhal artificial (grupo controle). Estes foram subdivididos em cinco subgrupos com cinco animais cada, com doses distintas de 200, 400, 600, 800 e 1000 mg kg-1, sendo utilizado no grupo controle o volume equivalente aos meios de contraste testados. Os animais foram avaliados após 5, 15, 30, 60, 120, 180 e 240 min da administração intracisternal dessas substâncias, quanto a sinais de depressão e excitação, reflexos tátil de agarramento palmar, flexor, extensor, palpebral, pupilar e da pina, reação de endireitamento e posicionamento e resposta auditiva. Nos sete dias subsequentes, os animais foram avaliados diariamente quanto a estes parâmetros, e ainda a massa corporal, a ingestão de ração e de água, foram mensuradas. Não foram observadas diferenças estatisticamente significativas entre os grupos testados com meios de contraste, em nenhum dos parâmetros avaliados. Dessa forma, nesse modelo animal, o iobitridol de