RESUMO

The role of Malassezia yeasts in dandruff and seborrheic dermatitis is unclear; however, antifungal therapy with ketoconazole is commonly used. We propose that ketoconazole shifts skin lipid profile, affects Malassezia lipid metabolism and favours biotin-producing bacteria. Biotin regulates inflammatory response and cell proliferation, contributing to symptom improvement.

Assuntos

Caspa , Dermatite Seborreica , Malassezia , Antifúngicos/farmacologia , Biotina , Biologia Computacional , Caspa/tratamento farmacológico , Caspa/microbiologia , Dermatite Seborreica/tratamento farmacológico , Dermatite Seborreica/microbiologia , Humanos , Cetoconazol/farmacologia , Metabolismo dos Lipídeos