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Background: The Transmissible Venereal Tumor (TVT), classified as a round cell tumor, is considered one of the oldestexisting tumors. It affects dogs all over the world and has a contagious characteristic. Despite the good response to clinicaltreatment in most cases, it can sometimes have non-classical presentations and even different behavior. Thus, the presentstudy aims to report 3 cases of atypical TVT treated at the Veterinary Medical Teaching Hospital of the State University ofMaringá (UEM) in Umuarama, Paraná, aiming to describe the epidemiology and clinical-pathological aspects, focusingon the diagnostic method used, the treatment of choice and the clinical follow-up of each case.Cases: Case records of 3 intact male mongrel dogs with atypical Transmissible Venereal Tumor (case 1: intranasal; case2: intra-abdominal and case 3: cutaneous with lymph node metastasis) were reviewed regarding history, clinical signs,duration of clinical signs, examination findings, results and findings of complementary exams (hematological, biochemical,radiographic, ultrasonographic and cytological), treatment, follow-up and final result. Case 1: had an ulcerated mass in thenasal plane causing significant airway obstruction and respiratory difficulty. Case 2: had a lesion in a typical location (penilemucosa in the glans area) but with a large intra-abdominal mass in the lumbar paravertebral region, causing compressionof important structures. Case 3: on the other hand, had cutaneous TVT with several ulcerated plaque lesions all over theskin, in addition to popliteal lymph node enlargement due to metastasis later confirmed by microscopy. All dogs reportedwere mixed breed, intact males with free access to the street. Despite...

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A hipoplasia renal ocorre quando há o desenvolvimento incompleto do rim, resultando em um menor número de néfrons, lóbulos e cálices ao nascimento do animal. A gravidade dessa anomalia depende do nível de acometimento. Quando unilateral, ocorre a hipertrofia compensatória do rim saudável e, em casos bilaterais, é frequente a ocorrência de insuficiência renal e infecções. Foi retratada como uma afecção hereditária em algumas raças puras ou mestiças de suínos, potros, caprinos, bovinos e cães, contudo, é incomum em felinos. O presente trabalho tem como objetivo relatar o caso de uma felina, sem raça definida, de dois meses de idade, com queixa de apatia, anorexia e êmes por três dias. No exame físico, foi observada desidratação estimada em 10%, tempo de preenchimento capilar de três segundos, hipotermia, hipoglicemia e letargia. Frente a essas alterações, foram solicitados exames complementares para melhor elucidação do quadro. Os exames bioquímicos revelaram azotemia e hiperfosfatemia grave, bem como hipercalcemia e hipercalemia leve. Já a urinálise, indicou redução da densidade urinária associada à presença de cilindros hialinos e céreos. A ultrassonografia abdominal evidenciou perda de diferenciação córtico-medular e diminuição de ambos os rins, alterações essas compatíveis com nefropatia. Instituiu-se tratamento paliativo visando minimizar complicações secundárias da injúria renal aguda, contudo, a paciente veio a óbito. Na necropsia, os rins apresentavam tamanho reduzido bilateralmente e o exame histopatológico revelou a presença de moderados glomérulos primitivos multifocais associados à distensão do espaço glomerular. A avaliação clínica e as lesões histopatológicas foram consistentes com o diagnóstico de hipoplasia renal congênita.

Renal hypoplasia occurs when there is incomplete development of the kidney, resulting in fewer nephrons, lobes and calyces at birth. The severity of this anomaly depends on the level of involvement. When unilateral, compensatory hypertrophy of the healthy kidney occurs and, in bilateral cases, renal failure and infections are frequent. It has been portrayed as an inherited condition in some pure or mixed breeds of pigs, foals, goats, cattle and dogs, however, it is uncommon in felines. This paper aims to report the case of a feline, mixed breed, two months old, with complaints of apathy, anorexia and emesis for three days. Physical examination showed an estimated dehydration of 10%, capillary refilling time of three seconds, hypothermia, hypoglycemia and lethargy. In view of these changes, complementary exams were requested to better clarify the condition. Biochemical examinations revealed severe azotemia and hyperphosphatemia, as well as hypercalcemia and mild hyperkalemia. Urinalysis, on the other hand, indicated a reduction in urinary density associated with the presence of hyaline and brain cylinders. Abdominal ultrasound showed a loss of corticomedullary differentiation and a decrease in both kidneys, changes compatible with nephropathy. Palliative treatment was instituted in order to minimize secondary complications of acute kidney injury, however, the patient died. At necropsy, the kidneys were bilaterally reduced in size and histopathological examination revealed the presence of moderate multifocal primitive glomeruli associated with distention of the glomerular space. Clinical evaluation and histopathological lesions were consistent with the diagnosis of congenital renal hypoplasia.

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Background: Histiocytic sarcoma can present in a localized or disseminated form, being a malignant neoplasm derived from interstitial dendritic cells. Another form of the disease is called hemophagocytic histiocystic sarcoma (HHS), which originates from macrophages located in the splenic red pulp and bone marrow. HHS is a rare neoplasm with unknown etiology and rapid development. It mainly affects middle-aged to elderly animals. It primarily affects the spleen and bone marrow, with occurence of metastases in other organs. Some canine breeds are considered more predisposed to this neoplasia, among them the Rottweiler. The aim of this study was to report a case of HHS in a Rottweiler dog. Case: An 8-year-old Rottweiler suffering from hyporexia and progressive weight loss for a month was attended at the Veterinary Hospital of State University of Maringá. On physical examination, he only presented mild discomfort on abdominal palpation. Blood count was performed, which revealed mild thrombocytopenia (145,000/µL, reference value for the species 150,000-500,000/µL). The Polymerase Chain Reaction (PCR) exam was requested for babesiosis and ehrlichiosis, due to a history of ectoparasites. The animal was released with the prescription of Doxycycline at a dose of 10 mg/kg orally for 28 days. After 5 days, the condition worsened and the animal returned with emesis, apathy and hyporexia, being hospitalized. Abdominal ultrasound, blood count, urinalysis, serum urea and creatinine tests were requested. Among the hematological changes, thrombocytopenia (116,000/µL) and the appearing of regenerative anemia and atypical round cells with ample and slightly basophilic cytoplasm in the smear, similar to histiocytes, stood out. On ultrasound examination, splenomegaly was observed with hypoechogenic areas. Ultrasound-guided fine-needle aspiration cytology (FNAC) of the spleen was performed, which...(AU)

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A obesidade é uma doença nutricional frequente em cães e gatos, leva a diversas alterações nas funções corporais e limita a longevidade dos animais. Vários fatores contribuem para o desenvolvimento da obesidade nos animais, como genética, idade, raça, falta de atividade física, composição calórica dos alimentos, tipo e a forma de alimentação, distúrbios hormonais, medicamentos e fatores relacionados com os proprietários. O presente estudo teve como objetivo obter informações através da avaliação dos aspectos hematológicos e bioquímicos envolvidos no desenvolvimento da obesidade animal, assim como obter informações por meio de um questionário aplicado aos tutores sobre o conhecimento da obesidade seus animais. Foram selecionados 20 animais, dos quais 50% apresentavam sobrepeso e os outros 50% eram obesos, seguindo o escore de condição corporal (ECC), descritos por (1). No hemograma os valores permaneceram dentro do valor de referência da espécie, já na análise bioquímica foi evidenciadas alterações na concentração de colesterol, glicose, triglicérides e creatinina ao serem comparadas com os valores de referências das espécies, essas alterações são importantes pois podem interferir no bem estar e na longevidade desses animas. Mais alarmente ainda foi a dificuldade dos tutores em reconhecerem o sobrepeso e a obesidade em seus animais de companhia, e quando identificada a baixa porcentagem de procura de orientações médicas veterinárias para controle ou tratamento.(AU)

Obesity is a frequent nutritional disease in dogs and cats, leads to several changes in body functions and limits the longevity of animals. Several factors contribute to the development of obesity in animals, such as genetics, age, race, lack of physical activity, caloric composition of food, type and form of feeding, hormonal disorders, medications and factors related to owners. The present study aimed to obtain information through the evaluation of hematological and biochemical aspects involved in the development of animal obesity, as well as obtain information through a questionnaire applied to tutors about the knowledge of obesity in their animals. Twenty animals were selected, of which 50% were overweight and the other 50% were obese following the body condition score (ECC) described by (1). In the blood count, the values remained within the reference value of the species, whereas in the biochemical analysis changes in the concentration of cholesterol, glucose, triglycerides and creatinine were shown when compared with the reference values of the species, these alterations are important because they can interfere with the well-being and longevity of these animals. Even more alarmingly was the tutors' difficulty in recognizing overweight and obesity in their pets, and when was identified the low percentage of seeking veterinary medical guidance for control or treatment.(AU)

La obesidad es una enfermedad nutricional frecuente en perros y gatos, provoca varios cambios en las funciones corporales y limita la longevidad de los animales. Varios factores contribuyen al desarrollo de la obesidad en animales, como la genética, la edad, la raza, la falta de actividad física, la composición calórica de los alimentos, el tipo y la forma de alimentación, los trastornos hormonales, los medicamentos y los factores relacionados con los propietarios. El presente estudio tuvo como objetivo obtener información a través de la evaluación de los aspectos hematológicos y bioquímicos involucrados en el desarrollo de la obesidad animal, así como obtener información a través de un cuestionario aplicado a los tutores sobre el conocimiento de la obesidad en sus animales. Se seleccionaron veinte animales, de los cuales el 50% tenían sobrepeso y el otro 50% eran obesos, siguiendo el puntaje de condición corporal (ECC), descrito por (1). En el recuento sanguíneo, los valores se mantuvieron dentro del valor de referencia de la especie, mientras que en el análisis bioquímico, se observaron cambios en la concentración de colesterol, glucosa, triglicéridos y creatinina en comparación con los valores de referencia de la especie, estos cambios son importantes porque pueden interferir en el bienestar y en la longevidad de estos animales. Aún más alarmante fue la dificultad de los tutores para reconocer el sobrepeso y la obesidad en sus mascotas, y cuando se identificó el bajo porcentaje de buscar orientación médica veterinaria para el control o el tratamiento.(AU)

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A obesidade é uma doença nutricional frequente em cães e gatos, leva a diversas alterações nas funções corporais e limita a longevidade dos animais. Vários fatores contribuem para o desenvolvimento da obesidade nos animais, como genética, idade, raça, falta de atividade física, composição calórica dos alimentos, tipo e a forma de alimentação, distúrbios hormonais, medicamentos e fatores relacionados com os proprietários. O presente estudo teve como objetivo obter informações através da avaliação dos aspectos hematológicos e bioquímicos envolvidos no desenvolvimento da obesidade animal, assim como obter informações por meio de um questionário aplicado aos tutores sobre o conhecimento da obesidade seus animais. Foram selecionados 20 animais, dos quais 50% apresentavam sobrepeso e os outros 50% eram obesos, seguindo o escore de condição corporal (ECC), descritos por (1). No hemograma os valores permaneceram dentro do valor de referência da espécie, já na análise bioquímica foi evidenciadas alterações na concentração de colesterol, glicose, triglicérides e creatinina ao serem comparadas com os valores de referências das espécies, essas alterações são importantes pois podem interferir no bem estar e na longevidade desses animas. Mais alarmente ainda foi a dificuldade dos tutores em reconhecerem o sobrepeso e a obesidade em seus animais de companhia, e quando identificada a baixa porcentagem de procura de orientações médicas veterinárias para controle ou tratamento.

Obesity is a frequent nutritional disease in dogs and cats, leads to several changes in body functions and limits the longevity of animals. Several factors contribute to the development of obesity in animals, such as genetics, age, race, lack of physical activity, caloric composition of food, type and form of feeding, hormonal disorders, medications and factors related to owners. The present study aimed to obtain information through the evaluation of hematological and biochemical aspects involved in the development of animal obesity, as well as obtain information through a questionnaire applied to tutors about the knowledge of obesity in their animals. Twenty animals were selected, of which 50% were overweight and the other 50% were obese following the body condition score (ECC) described by (1). In the blood count, the values remained within the reference value of the species, whereas in the biochemical analysis changes in the concentration of cholesterol, glucose, triglycerides and creatinine were shown when compared with the reference values of the species, these alterations are important because they can interfere with the well-being and longevity of these animals. Even more alarmingly was the tutors' difficulty in recognizing overweight and obesity in their pets, and when was identified the low percentage of seeking veterinary medical guidance for control or treatment.

La obesidad es una enfermedad nutricional frecuente en perros y gatos, provoca varios cambios en las funciones corporales y limita la longevidad de los animales. Varios factores contribuyen al desarrollo de la obesidad en animales, como la genética, la edad, la raza, la falta de actividad física, la composición calórica de los alimentos, el tipo y la forma de alimentación, los trastornos hormonales, los medicamentos y los factores relacionados con los propietarios. El presente estudio tuvo como objetivo obtener información a través de la evaluación de los aspectos hematológicos y bioquímicos involucrados en el desarrollo de la obesidad animal, así como obtener información a través de un cuestionario aplicado a los tutores sobre el conocimiento de la obesidad en sus animales. Se seleccionaron veinte animales, de los cuales el 50% tenían sobrepeso y el otro 50% eran obesos, siguiendo el puntaje de condición corporal (ECC), descrito por (1). En el recuento sanguíneo, los valores se mantuvieron dentro del valor de referencia de la especie, mientras que en el análisis bioquímico, se observaron cambios en la concentración de colesterol, glucosa, triglicéridos y creatinina en comparación con los valores de referencia de la especie, estos cambios son importantes porque pueden interferir en el bienestar y en la longevidad de estos animales. Aún más alarmante fue la dificultad de los tutores para reconocer el sobrepeso y la obesidad en sus mascotas, y cuando se identificó el bajo porcentaje de buscar orientación médica veterinaria para el control o el tratamiento.

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Background: Histiocytic sarcoma can present in a localized or disseminated form, being a malignant neoplasm derived from interstitial dendritic cells. Another form of the disease is called hemophagocytic histiocystic sarcoma (HHS), which originates from macrophages located in the splenic red pulp and bone marrow. HHS is a rare neoplasm with unknown etiology and rapid development. It mainly affects middle-aged to elderly animals. It primarily affects the spleen and bone marrow, with occurence of metastases in other organs. Some canine breeds are considered more predisposed to this neoplasia, among them the Rottweiler. The aim of this study was to report a case of HHS in a Rottweiler dog. Case: An 8-year-old Rottweiler suffering from hyporexia and progressive weight loss for a month was attended at the Veterinary Hospital of State University of Maringá. On physical examination, he only presented mild discomfort on abdominal palpation. Blood count was performed, which revealed mild thrombocytopenia (145,000/µL, reference value for the species 150,000-500,000/µL). The Polymerase Chain Reaction (PCR) exam was requested for babesiosis and ehrlichiosis, due to a history of ectoparasites. The animal was released with the prescription of Doxycycline at a dose of 10 mg/kg orally for 28 days. After 5 days, the condition worsened and the animal returned with emesis, apathy and hyporexia, being hospitalized. Abdominal ultrasound, blood count, urinalysis, serum urea and creatinine tests were requested. Among the hematological changes, thrombocytopenia (116,000/µL) and the appearing of regenerative anemia and atypical round cells with ample and slightly basophilic cytoplasm in the smear, similar to histiocytes, stood out. On ultrasound examination, splenomegaly was observed with hypoechogenic areas. Ultrasound-guided fine-needle aspiration cytology (FNAC) of the spleen was performed, which...

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Background: The Pelger-Huët anomaly is a congenital alteration in segmented neutrophil, eosinophil and basophil morphology consisting of nuclear hypo-segmentation. It presents in two ways: the homozygote (very rare) presenting granulocytes with rounded nuclei and dense chromatin, where nuclei with more than two lobes are not found; and in the heterozygote form which presents leukocytes with bi-lobulated nuclei, yet leukocytes that seem immature can also be found. Diagnosis is important for preventing WBC interpretation errors. The objective of this study is to report a case of the heterozygote form of Perger-Huët anomaly in an Australian Shepherd bit.Case: A 6-year-old Australian Shepherd bitch, weighing 28 kg, was received to perform tartar cleaning at the Veterinary Hospital (HV) of the Universidade Estadual de Maringá (UEM), in Umuarama in Paraná State. In the anamnesis, the owner reported that the animal was healthy, vaccinated, and had not made use of medications recently. Upon physical examination, the animal was overweight, with adequate hydration, alert consciousness level, no exo-parasites present, rectal temperature of 39.3°C (37.5 to 39.2), heart rate of 96 beats per min (60 to 120 beats per min), breathing (18 to 36 movements per min), a two second capillary perfusion time, strong and regular pulse, hyperemic oral mucosa, and otherwise, a normal-colored and popliteal reactive left lymph. Semiological evaluation presented no alteration. Due to the tartar cleaning procedure, a hemogram was requested. Blood smear analysis from the first blood workup showed a large increase in the number of hypo-segmented leukocytes, with a pattern of mature chromatin, in the form of bands and meta-myelocytes, characterizing a deviation to the left, all of which did not correspond to the patient’s clinical presentation.[...]

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Background: The Pelger-Huët anomaly is a congenital alteration in segmented neutrophil, eosinophil and basophil morphology consisting of nuclear hypo-segmentation. It presents in two ways: the homozygote (very rare) presenting granulocytes with rounded nuclei and dense chromatin, where nuclei with more than two lobes are not found; and in the heterozygote form which presents leukocytes with bi-lobulated nuclei, yet leukocytes that seem immature can also be found. Diagnosis is important for preventing WBC interpretation errors. The objective of this study is to report a case of the heterozygote form of Perger-Huët anomaly in an Australian Shepherd bit.Case: A 6-year-old Australian Shepherd bitch, weighing 28 kg, was received to perform tartar cleaning at the Veterinary Hospital (HV) of the Universidade Estadual de Maringá (UEM), in Umuarama in Paraná State. In the anamnesis, the owner reported that the animal was healthy, vaccinated, and had not made use of medications recently. Upon physical examination, the animal was overweight, with adequate hydration, alert consciousness level, no exo-parasites present, rectal temperature of 39.3°C (37.5 to 39.2), heart rate of 96 beats per min (60 to 120 beats per min), breathing (18 to 36 movements per min), a two second capillary perfusion time, strong and regular pulse, hyperemic oral mucosa, and otherwise, a normal-colored and popliteal reactive left lymph. Semiological evaluation presented no alteration. Due to the tartar cleaning procedure, a hemogram was requested. Blood smear analysis from the first blood workup showed a large increase in the number of hypo-segmented leukocytes, with a pattern of mature chromatin, in the form of bands and meta-myelocytes, characterizing a deviation to the left, all of which did not correspond to the patients clinical presentation.[...](AU)

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