Assuntos
Drama , Literatura Moderna , Medicina na Literatura , Oftalmologia , Poesia como Assunto , Olho , História do Século XX , Humanos , Metáfora , México , Miopia , Prêmio Nobel , Visão OcularAssuntos
Drama , Literatura Moderna , Medicina na Literatura , Oftalmologia , Poesia como Assunto , História do Século XX , MéxicoRESUMO
From a group of 50 premature newborns with central and mixed apnea, 34 received a loading dose of 4.3 mg/kg intravenous theophylline (group I) and 16 received 6 mg/kg orally (group II); the maintenance dose was 0.86 and 1 mg/kg every eight hours, respectively. Mean maximum serum concentrations after the loading dose were 5.8 +/- 2.3 mcg/mL in 25 newborns from group I, and 6.6 +/- 1,3 mcg/mL in 8 newborns from group II (P less than 0.20). Mean maximum concentration after the fifth maintenance dose was 7.5 +/- 1.7 mcg/mL in 26 newborns from group I, and 5.8 +/- 1.4 mcg/mL in 16 newborns from group II (P = 0.001); mean minimum concentration was 5.3 +/- 1.6 mcg/mL and 4.5 +/- 1.4 mcg/mL, respectively (P greater than 0.10). Mean clearance was 30.21 +/- 11.03 and 27.1 +/- 7.7 mL/kg/h; mean apparent distribution volume was 0.5 +/- 0.25 and 0.76 +/- 0.32 L/kg; elimination rate constant was 0.049 +/- 0.04 and 0.040 +/- 0.03/h-1 for both groups respectively, with significant differences between groups only in the apparent distribution volume (P less than 0.001). Half-life time (T1/2) was from four to 118 hours. The study population was divided into three groups according to half-life time: those with a half-life time of lesser than 20 hours (47.6%); an intermediate half-life time of from 20 to 30 hours (23.8%); and a long half-life time of more than 31 hours (28.6%).(ABSTRACT TRUNCATED AT 250 WORDS)
Assuntos
Apneia/tratamento farmacológico , Doenças do Prematuro/tratamento farmacológico , Teofilina/farmacocinética , Administração Oral , Apneia/sangue , Esquema de Medicação , Meia-Vida , Humanos , Recém-Nascido , Doenças do Prematuro/sangue , Injeções Intravenosas , Teofilina/administração & dosagemRESUMO
The results in morbidity and mortality between 415 newborn infants with birth weight under 2,500 g are presented; the patients with great congenital malformations were not included. The population was divided in three categories 1,500-2,499 g, 1,000-1,499 g and less than 1,000 g and each categorie was divided in small for gestational age (SGE) and appropriate for gestational age (AGE). The mortality rate was very high in the extreme low birth weight. 67% of the population were AGE y 33% for SGE. The intrahospitalary morbidity was different between each group, being the SGE with less morbidity and less length of hospitalization, with no relation to birth weight. In our study there was no differences between perinatal asphyxia and birth weight, probably because the SGE babies born in better conditions than the other group.
Assuntos
Recém-Nascido de Baixo Peso , Doenças do Recém-Nascido/epidemiologia , Idade Gestacional , Humanos , Recém-Nascido , Doenças do Recém-Nascido/mortalidade , Recém-Nascido Pequeno para a Idade Gestacional , Taxa de SobrevidaAssuntos
Gravidez , Vitamina E/sangue , Adolescente , Adulto , Fatores Etários , Feminino , Idade Gestacional , Humanos , Masculino , Valores de Referência , Caracteres SexuaisRESUMO
Para conocer los niveles sericos de vitamina E de nuestra poblacion adulta, se analizaron las muestras sanguineas de 50 hombres, 50 mujeres y 53 embarazadas a diferentes edades gestacionales. Todos ellos sanos. La tecnica de laboratorio utilizada para tal medicion fue la sugerida por J. Fabianek. Los resultados muestran que para el grupo masculino el nivel promedio detectado fue de 0,50 mg/100 ml con desviacion estandar (DE) de 0.11; para el femenino fue de 0,48 mg/100 ml con DE de 0.01 y para el grupo de embarazadas estos niveles cambian: es asi, que para el primer trimestre el nivel promedio detectado fue de 0.44 mg/100 ml con DE de 0.11; para el segundo trimestre fue de 0.63 mg/100 ml con DE de 0.15 y para el tercer trimestre el nivel detectado fue de 0,76 mg/100 ml con DE de 0.14. Se observo in incremento en los niveles sericos de esta vitamina a mayor edad y na relacion directamente proporcional a las semanas de gestacion (p< 0.05). No se comprobo significacion entre sexos. Consideramos importantes estos datos para relacionar los niveles normales en el sector femenino y prevenir deficiencias que lleven consigo un sindrome de anemia hemolitica por deficit de vitamina.E en los neonatos futurus