RESUMO
BACKGROUND: Guillain-Barré syndrome (GBS) is an acute, immune-mediated flaccid paralysis frequently associated with Campylobacter infection. Of two predominant GBS subtypes, a demyelinating subtype (acute inflammatory demyelinative polyneuropathy [AIDP]) predominates in the United States and Europe, and axonal subtype (acute motor axonal neuropathy [AMAN]) is the predominant form in China. Previous clinical studies suggested that AMAN also occurs in Mexican children. The purpose of this study was to describe the subtypes of GBS in children from Mexico City. METHODS: We prospectively studied 121 children admitted to two pediatric hospitals in Mexico City from 1996 to 2002. Clinical histories were obtained, electrophysiologic studies were performed to determine GBS subtype, and microbiologic studies were performed. RESULTS: Of the 121 children, 46 had AMAN and 32 had AIDP. The male to female ratio was 1.3 for AMAN cases (mean age = 6.3) and 3.0 for AIDP cases (mean age = 7.0). There was a strong seasonal distribution of AMAN cases in July to September. Children with AMAN, but not AIDP, had worsening of illness during hospitalization as judged by peak severity scores. Vomiting was more likely in AIDP (28.1%) vs AMAN (6.5%) (p = 0.012) and diarrhea was more common in AMAN (32.6%) than AIDP (12.5%) (p = 0.06). IgG anti-GM1 antibody titers were higher in patients with AMAN vs AIDP (p = 0.067). Anti-GD1a antibodies were equally present in both groups. Anti GQ1b titers were higher in AMAN vs AIDP (p = 0.009). Campylobacter antibody responses were positive in 44.1% of patients with AMAN and 37.0% of patients with AIDP. Twenty patients (14 = AMAN, 6 = AIDP) had positive stool cultures for C jejuni. Two serotypes, HS:19 and HS:41, accounted for 6 of 10 Campylobacter isolates available for serotyping from these cases. CONCLUSIONS: This study confirms that acute motor axonal neuropathy is an important Guillain-Barré syndrome subtype in Mexican children, is associated with diarrhea, and occurs seasonally.
Assuntos
Síndrome de Guillain-Barré/epidemiologia , Síndrome de Guillain-Barré/fisiopatologia , Adolescente , Infecções por Campylobacter/epidemiologia , Criança , Pré-Escolar , Diarreia/etiologia , Feminino , Gangliosídeo G(M1)/análogos & derivados , Gangliosídeo G(M1)/imunologia , Síndrome de Guillain-Barré/microbiologia , Humanos , Imunoglobulina G/sangue , Lactente , Masculino , México/epidemiologia , Neurônios Motores/patologia , Estações do AnoRESUMO
Se informa que los derivados orthohidroxilados de las aminas aromáticas son metabolitos que se liberan en la vejiga donde originan carcinomas. Se producen en el metabolismo del triptófano cuerpos con estructura similar, entre ellos la 3-hidrociquinurenina y el ácido carcinogenético. Se encuentran estos cuerpos en cantidades excesivas en la orina de los fumadores, quienes son incapaces de transformarlos en nicotenamida. Los fumadores en un grupo de 90 enfermos con carcinoma transicional de vejiga, alcanzaron el 90 porciento, en tanto que en el grupo control, constituido por 90 enfermos con carcinoma del colon, sólo alcanzaron el 40 porciento: 5 porciento>2 (AU)