RESUMO
The cancer stem cells hypothesis arises from observation of normal tissue hierarchy and the demonstration of stem cells in normal tissues. Scientists continue to debate whether the putative cancer cells derive from the transformation of normal tissue stem cells or from more differentiated cells. The existence of a subpopulation of tumour cells with stem-cell-like characteristics, including very slow replication and resistance to standard chemotherapy, posses a novel therapeutic challenge. This review summarises the state of development of normal and cancer breast cells and the clinical and therapeutic relevance.
Assuntos
Neoplasias da Mama/etiologia , Carcinoma/etiologia , Células-Tronco Neoplásicas/fisiologia , Neoplasias da Mama/classificação , Neoplasias da Mama/patologia , Carcinoma/classificação , Carcinoma/patologia , Separação Celular/métodos , Transformação Celular Neoplásica/patologia , Feminino , Humanos , Modelos Biológicos , Modelos Teóricos , Células-Tronco Neoplásicas/citologia , Células-Tronco Neoplásicas/patologiaRESUMO
Espínola was born in Teguise (Lanzarote) in 1845. He studied medicine in Cadiz and moved to Montevideo in 1878. He performed his great medico-social and philantropic work in Las Piedras. He died in San José de Mayo in 1905. Some biographic notes through several journalist sources from Uruguay and Canary Islands are presented. (AU)