RESUMO
OBJECTIVE: Community intervention was undertaken using the health promotion strategy, the objective being to develop a health education program for women. METHODS: The popular education methodology was used with the purpose of generating organizational and social participation processes to improve hates of child nutrition and survival. RESULTS: The main results are linked with the generation of community self-care processes and the creation of a health promoters' group which has been working with women, focusing their work on improving child nutrition and family health. The health promoters have taken charge of the epidemiological surveillance program for child nutrition and, together with the mothers, have undertaken a series of actions which have helped to decrease the rate of malnutrition among the children participating in this programs. CONCLUSIONS: There would be greater possibility of success if the general population were involved in the solution of this problem. This would be possible by the use of an adequate methodology which brought about greater community participation in such a way as to leave room for its own improvement. Popular education provides such a tool. It is necessary to continue to increase experience in health education with this type of methodology.
Assuntos
Fenômenos Fisiológicos da Nutrição Infantil , Educação em Saúde , Promoção da Saúde , Saúde da População Rural , Pré-Escolar , Feminino , Humanos , Lactente , Fenômenos Fisiológicos da Nutrição do Lactente , Recém-Nascido , México , Estado NutricionalRESUMO
Gap junctions are constituted by intercellular channels and provide a pathway for transfer of ions and small molecules between adjacent cells of most tissues. The degree of intercellular coupling mediated by gap junctions depends on the number of gap junction channels and their activity may be a function of the state of phosphorylation of connexins, the structural subunit of gap junction channels. Protein phosphorylation has been proposed to control intercellular gap junctional communication at several steps from gene expression to protein degradation, including translational and post-translational modification of connexins (i.e., phosphorylation of the assembled channel acting as a gating mechanism) and assembly into and removal from the plasma membrane. Several connexins contain sites for phosphorylation for more than one protein kinase. These consensus sites vary between connexins and have been preferentially identified in the C-terminus. Changes in intercellular communication mediated by protein phosphorylation are believed to control various physiological tissue and cell functions as well as to be altered under pathological conditions.
Assuntos
Conexinas/metabolismo , Junções Comunicantes/metabolismo , Conexinas/fisiologia , FosforilaçãoRESUMO
Gap junctions are constituted by intercellular channels and provide a pathway for transfer of ions and small molecules between adjacent cells of most tissues. The degree of intercellular coupling mediated by gap junctions depends on the number of gap junction channels and their activity may be a function of the state of phosphorylation of connexins, the structural subunit of gap junction channels. Protein phosphorylation has been proposed to control intercellular gap junctional communication at several steps from gene expression to protein degradation, including translational and post-translational modification of connexins (i.e., phosphorylation of the assembled channel acting as a gating mechanism) and assembly into and removal from the plasma membrane. Several connexins contain sites for phosphorylation for more than one protein kinase. These consensus sites vary between connexins and have been preferentially identified in the C-terminus. Changes in intercellular communication mediated by protein phosphorylation are believed to control various phsysiological tissue and cell functions as well as to be altered under pathological conditions. (AU)Gap junctions are constituted by intercellular channels and provide a pathway for transfer of ions and small molecules between adjacent cells of most tissues. The degree of intercellular coupling mediated by gap junctions depends on the number of gap junction channels and their activity may be a function of the state of phosphorylation of connexins, the structural subunit of gap junction channels. Protein phosphorylation has been proposed to control intercellular gap junctional communication at several steps from gene expression to protein degradation, including translational and post-translational modification of connexins (i.e., phosphorylation of the assembled channel acting as a gating mechanism) and assembly into and removal from the plasma membrane. Several connexins contain sites for phosphorylation for more than one protein kinase. These consensus sites vary between connexins and have been preferentially identified in the C-terminus. Changes in intercellular communication mediated by protein phosphorylation are believed to control various phsysiological tissue and cell functions as well as to be altered under pathological conditions.
Assuntos
Conexinas/metabolismo , Junções Comunicantes/metabolismo , Comunicação Celular , Conexinas/fisiologia , FosforilaçãoRESUMO
Toxoplasmic encephalitis (TE) is among the most common neurologic affections and it is the most prevalent cause of intracerebral mass lesions in AIDS patients. All patients with AIDS hospitalized at the Hospital de Clínicas de Porto Alegre between May/85 and December/91 (516 cases) had their files revised to determinate TE prevalence, serology, sensitivity and specificity of the computed tomography (CT) brain scan, clinical findings and serology to make its diagnosis. The prevalence on CT was 13% (presumptive diagnosis). Blood serology and cerebrospinal (CSF) serology to toxoplasma were positive respectively in 65% and 49%. Autopsies of 125 patients were also revised with a prevalence of 22% (definite diagnosis). CT scan had 65% of sensitivity and 82% of specificity. Sensitivity and specificity of serology on blood was respectively 95% and 30%, while the cerebrospinal fluid (CSF) serology had 77% of sensitivity and 56% of specificity. The following clinical findings were considered: fever (sensitivity = 92%; specificity = 56%), neurological focal signs (sensitivity = 59%; specificity = 82%) and headache (sensitivity = 41%; specificity = 69%). We conclude that, based on the high serology sensitivity and high CT scan specificity, they constitute an useful approach to make TE diagnosis.
Assuntos
Infecções Oportunistas Relacionadas com a AIDS/diagnóstico , Anticorpos Antiprotozoários/sangue , Encefalite/diagnóstico , HIV-1 , Tomografia Computadorizada por Raios X , Toxoplasma/imunologia , Toxoplasmose Cerebral/diagnóstico , Infecções Oportunistas Relacionadas com a AIDS/epidemiologia , Infecções Oportunistas Relacionadas com a AIDS/patologia , Animais , Encéfalo/patologia , Brasil/epidemiologia , Encefalite/epidemiologia , Encefalite/patologia , Feminino , Imunofluorescência , Humanos , Masculino , Prevalência , Sensibilidade e Especificidade , Toxoplasmose Cerebral/epidemiologia , Toxoplasmose Cerebral/patologiaRESUMO
Se estudio por primera vez la enterotoxina de Clostridium perfringens (CPE) en el modelo intestino aislado de conejo.Se observaron cambios marcados sobre todo en fuerza con aumento inicial (6 min.) y luego disminucion paulatina (80 min.) para luego dar lugar a paralisis total (180 min.). La frecuencia por lo tanto tambien fue afectada en los estudios finales.A los 128 min se observaron periodos intermitentes de paralisis. El modelo sugirio la posibilidad de replicar in vitro pero en un modelo biologico, un "colico". Las lesiones histopatologicas observadas fueron principalmente de tipo descamacion, necrosis y degeneracion de la mucosa y vellosidades pero sin alteracion de la arquitectura. Se sugiere que los cambios observados son mas de tipo topico por lesiones a la mucosa, que de tipo farmaco sistemico