RESUMO
Nitazoxanide is a new broad-spectrum, antiparasitic drug agent. The photodegradation of nitazoxanide was studied in order to investigate the degradation kinetics of this drug. The analyses of the degraded samples were performed by a stability-indicating liquid chromatographic method. The degradation was carried out in acetonitrile with coated tablets or oral suspension powder in quartz cells under UVC light at 254 nm. The kinetics parameters, such as order of reaction, rate constants, half-life (t(1/2)), and the time when 90% of the drug original concentration was left, were determined. The photodegradation of nitazoxanide for both pharmaceutical formulations in acetonitrile solution shows a zero-order kinetics under the applied experimental conditions. The obtained results confirm the reliability of the chromatographic method for determining the kinetics run of nitazoxanide in the presence of its degradation products. The present study reveals the photolability of the drug in solution. Thus, appropriated photoprotection is recommended during the manipulation of the drug.
Assuntos
Antiparasitários/química , Química Farmacêutica , Cromatografia Líquida/métodos , Fotólise , Tiazóis/química , Estabilidade de Medicamentos , Cinética , Nitrocompostos , Pós , Comprimidos , Raios UltravioletaRESUMO
Foram realizados 138 testes com histoplasmina e paracoccidioidina no municipio de Pereiro - Ceara, obtendo-se positividade de 6l,5 por cento e 32,1 por cento respectivamente, a estes antigenos. Os autores discutem a possibilidade da coexistencia da histoplasmose e paracoccidioidomicose-infeccao e/ou doenca na regiao
Assuntos
Humanos , Histoplasmina/imunologia , Histoplasmose/epidemiologia , Histoplasmose/imunologia , Paracoccidioidomicose/epidemiologia , Paracoccidioidomicose/imunologia , Brasil , Brasil/epidemiologia , Histoplasmose/diagnóstico , Testes Intradérmicos , Paracoccidioidomicose/diagnósticoRESUMO
Intradermal tests using histoplasmin and paracoccidioidin antigens were performed in 138 persons from Pereiro, Ceará, Brazil. The results were positive in 61.5% and 32.5% with histoplasmin and paracoccidioidin antigens respectively. These results suggest infection by H. capsulatum and P. brasiliensis in the people living in the studied area. New studies are necessary to detect histoplasmosis and paracoccidioidomycosis as clinical diseases in that region.