RESUMO

Recent findings indicate that the motor and premotor cortices are hyperexcitable in obsessive-compulsive disorder (OCD). The authors have performed the first randomized, double-blind clinical trial of repetitive transcranial magnetic stimulation (rTMS) in OCD, with a 3-month follow-up. OCD patients (N=22) were assigned to either 2 weeks of active or sham rTMS to the supplementary motor area bilaterally. After 14 weeks, the response rate was 41% (7/12) with active and 10% (1/10) with sham treatment. At 14 weeks, patients receiving active rTMS showed, on average, a 35% reduction on the Y-BOCS, as compared with a 6.2% reduction in those receiving sham treatment.

Assuntos

Córtex Cerebral/fisiopatologia , Transtorno Obsessivo-Compulsivo/terapia , Estimulação Magnética Transcraniana/métodos , Adolescente , Adulto , Método Duplo-Cego , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Transtorno Obsessivo-Compulsivo/fisiopatologia , Resultado do Tratamento