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1.
J Pediatr ; 129(3): 339-45, 1996 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-8804321

RESUMO

OBJECTIVE: To evaluate the clinical features and outcome of antiphospholipid syndrome (APS) in children. STUDY DESIGN: Retrospective chart review of patients seen at the Children's Hospital of Philadelphia and Children's Seashore House Pediatric Rheumatology Center between 1988 and 1993. RESULTS: Nine patients with ages ranging from 8 months to 17 years are presented. Clinical features of five patients with primary APS, described in detail, were digital ischemia, stroke, chorea, Addison disease, and pulmonary vaso-occlusive disease. The four children with secondary APS had systemic lupus erythematosus. Clinical features of these patients include livedo reticularis, deep venous thrombosis, and pulmonary hypertension. Antiphospholipid titers, results of coagulation studies, and serologic findings did not predict outcome. CONCLUSION: APS in children has diverse clinical features similar to those in adults and should be considered in cases of unexplained vaso-occlusive disease.


Assuntos
Síndrome Antifosfolipídica/diagnóstico , Adolescente , Síndrome Antifosfolipídica/complicações , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Masculino , Estudos Retrospectivos
2.
J Pediatr ; 123(4): 586-8, 1993 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-8410513

RESUMO

We describe five children with varied rheumatic manifestations, including fibromyalgia and arthralgias, ultimately proved to be associated with hypothyroidism. All musculoskeletal symptoms improved after thyroid replacement therapy. We conclude that rheumatic manifestations of hypothyroidism can be as varied in children as in adults.


Assuntos
Hipotireoidismo/complicações , Artropatias/etiologia , Doenças Musculares/etiologia , Adolescente , Criança , Pré-Escolar , Diagnóstico Diferencial , Feminino , Humanos , Hipotireoidismo/diagnóstico , Hipotireoidismo/epidemiologia , Masculino , Estudos Retrospectivos
3.
J Rheumatol ; 20(10): 1774-6, 1993 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-8295193

RESUMO

Reflex sympathetic dystrophy (RSDS) is a syndrome of hyperesthesia and vasomotor disturbance of an extremity, often following trauma or an inflammatory process. We describe a patient with systemic lupus erythematosus (SLE) and recurrent RSDS involving all 4 extremities at various times during her illness. Treatments, including corticosteroid use, physical therapy and at times sympathetic nerve blockade led to the resolution of each episode. We suggest the diagnosis of RSDS be considered in patients with connective tissue diseases who present with atypical pain syndromes not attributable to their primary illness.


Assuntos
Lúpus Eritematoso Sistêmico/complicações , Distrofia Simpática Reflexa/etiologia , Adolescente , Corticosteroides/uso terapêutico , Bloqueio Nervoso Autônomo , Extremidades , Feminino , Humanos , Modalidades de Fisioterapia , Recidiva , Distrofia Simpática Reflexa/terapia
4.
J Pediatr ; 122(4): 595-8, 1993 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-8463908

RESUMO

Many children with acute leukemia have musculoskeletal complaints and non-specific hematologic abnormalities. A total of 10 children with acute leukemia and 10 with systemic juvenile rheumatoid arthritis were compared to delineate which early features could differentiate these diagnoses. Attention to evolving hematologic abnormalities and musculoskeletal findings may expedite diagnosis of these diseases.


Assuntos
Artrite Juvenil/diagnóstico , Leucemia-Linfoma Linfoblástico de Células Precursoras/diagnóstico , Artrite/etiologia , Artrite Juvenil/epidemiologia , Criança , Diagnóstico Diferencial , Feminino , Humanos , Masculino , Doenças Musculares/etiologia , Leucemia-Linfoma Linfoblástico de Células Precursoras/complicações , Leucemia-Linfoma Linfoblástico de Células Precursoras/epidemiologia , Estudos Retrospectivos
5.
J Pediatr ; 117(4): 653-9, 1990 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-2213397

RESUMO

Twenty-nine children with juvenile rheumatoid arthritis were studied to determine the safety and efficacy of methotrexate therapy. The initial dose of methotrexate averaged 7.1 mg/m2/wk and was given as a single, oral weekly dose or as three divided doses, each separated by 12 hours. Current antiinflammatory medications were continued; 25 of 29 children had had lack of efficacy, and 8 of 29 had toxic effects, with one or more prior drugs such as intramuscularly or orally administered gold, hydroxychloroquine, or D-penicillamine. Intolerable corticosteroid dependency or toxic effects were present in 18 of 29 cases. Methotrexate-treated patients were examined monthly; minimum treatment duration required to assess efficacy and toxicity was 6 months. The range of treatment duration was 8 to 39 months (mean 18.5 months). Efficacy was assessed by comparing pretreatment versus posttreatment fever and rash, swollen-joint counts, articular indexes, duration of morning stiffness, functional class, hemoglobin levels, and platelet counts. Treatment with methotrexate effectively controlled fever and rash in 83% of children with systemic juvenile rheumatoid arthritis, reduced morning stiffness by 63%, eliminated recalcitrant joint restriction in 48%, and reduced numbers of swollen joints and swelling indexes by 46% and 52%, respectively. No significant toxic effects were observed. Juvenile rheumatoid arthritis of long duration, or with major erosions, was more likely to be refractory to methotrexate therapy. We recommend earlier consideration of methotrexate in place of other slow-acting antirheumatic drugs for juvenile rheumatoid arthritis not responding well to usual therapy. Future studies should address potential methotrexate toxic effects in the lungs and reproductive system, as well as outcome after discontinuation of methotrexate treatment.


Assuntos
Artrite Juvenil/tratamento farmacológico , Metotrexato/uso terapêutico , Adolescente , Anti-Inflamatórios não Esteroides/uso terapêutico , Criança , Pré-Escolar , Quimioterapia Combinada , Feminino , Humanos , Masculino , Metotrexato/administração & dosagem , Metotrexato/efeitos adversos
6.
Br J Dermatol ; 121(5): 655-8, 1989 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-2597636

RESUMO

A 13-year-old girl with cystic fibrosis (CF), severe lung disease, purpura on the lower extremities and with elevated serum mixed cryoglobulins is described. The possible relationship of the purpura in CF with cryoglobulinaemia is discussed.


Assuntos
Crioglobulinemia/complicações , Fibrose Cística/complicações , Púrpura Hiperglobulinêmica/etiologia , Adolescente , Feminino , Humanos
7.
J Pediatr ; 109(5): 753-8, 1986 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-3772655

RESUMO

We report 25 children with oligoarticular arthritis associated with Lyme disease. There were 16 boys (male/female ratio 1.8:1); ages ranged from 2 to 15 years. Thirteen (52%) children had no history of erythema chronicum migrans or other rash. Thirteen had temperatures as high as 41 degrees C for up to 2 months before the onset of arthritis. Twelve recalled definite tick bites. Ten (40%) children, of whom seven had no history of rash, were hospitalized for presumed septic arthritis. Another four had diagnoses of pauciarticular juvenile rheumatoid arthritis for as long as 3 years. Seven patients had less acute, recurrent episodes of synovitis. Two children had seventh nerve palsies 2 months before onset of arthritis. All patients had antibodies to the Lyme spirochete. In 14 patients, synovial fluid white blood cell counts ranged from 180 to 97,700/mm3 (greater than or equal to 76% polymorphonuclear leukocytes). Antibiotic therapy was effective in all patients; in 13, orally administered therapy alone resulted in elimination of synovitis and recurrent attacks. Lyme arthritis may be confused with acute bacterial septic arthritis or recurrent "pauciarticular juvenile rheumatoid arthritis," particularly when there is no history of erythema chronicum migrans.


Assuntos
Artrite Infecciosa/diagnóstico , Doença de Lyme/diagnóstico , Adolescente , Antibacterianos/uso terapêutico , Anticorpos Antibacterianos/análise , Artrite Infecciosa/tratamento farmacológico , Artrite Infecciosa/etiologia , Artrite Infecciosa/imunologia , Contagem de Células Sanguíneas , Criança , Pré-Escolar , Diagnóstico Diferencial , Feminino , Seguimentos , Humanos , Doença de Lyme/tratamento farmacológico , Doença de Lyme/imunologia , Masculino , Penicilinas/uso terapêutico , Recidiva , Dermatopatias/etiologia , Líquido Sinovial/citologia , Sinovite/etiologia
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