RESUMO
During recovery from severe wasting, malnourished children gain weight at greatly accelerated rates. To determine if additional zinc added to their basal therapeutic diets increased the retention of lean tissue and stimulated protein metabolism, we studied three groups of children taking either the basal diet alone or the basal diet supplemented with either 76 mumol (5 mg) or 153 mumol (10 mg) Zn/kg diet. The zinc-supplemented children gained similar weight and consumed the same amount of diet as the unsupplemented children. Zinc supplementation resulted in a greater net absorption of nitrogen and a higher rate of protein turnover, as estimated from urinary ammonia 15N enrichment after oral [15N]glycine. We conclude that additional zinc affected the composition of newly synthesized tissue and intermediary nitrogen metabolism.
Assuntos
Alimentos Fortificados , Desnutrição Proteico-Calórica/dietoterapia , Zinco/administração & dosagem , Pré-Escolar , Humanos , Lactente , Masculino , Nitrogênio/metabolismo , Desnutrição Proteico-Calórica/metabolismo , Aumento de PesoRESUMO
We report a case of herpes simplex hepatitis in a child with edematous malnutrition. Electron microscopy showed virus in parenchymal cells, with pulmonary embolization of necrotic, infected hepatic cell fragments. Systemic dissemination of herpes simplex may be related both to the profound immunoincompetence associated with kwashiorkor and to a reduction in the circulating and fixed polyanions that normally inhibit viral attachment to cells.
Assuntos
Hepatite Viral Humana/complicações , Herpes Simples/complicações , Kwashiorkor/complicações , Embolia Pulmonar/etiologia , Capilares/microbiologia , Hepatite Viral Humana/patologia , Herpes Simples/patologia , Humanos , Lactente , Kwashiorkor/patologia , Fígado/microbiologia , Fígado/patologia , Fígado/ultraestrutura , Pulmão/ultraestrutura , Masculino , Microscopia Eletrônica , Embolia Pulmonar/complicações , Embolia Pulmonar/microbiologia , Embolia Pulmonar/patologia , Simplexvirus/isolamento & purificaçãoAssuntos
Criança , Humanos , Feminino , Glicemia , Kwashiorkor , Diabetes Mellitus , Insulina , Peso CorporalRESUMO
Zinc-deficient animals and children have thymic atrophy and an increased susceptibility to infections. Children with protein-energy malnutrition similarly have thymic atrophy, zinc deficiency, and increased susceptibility to infections. 8 children, recently malnourished, who were supplemented with zinc, showed an increase in thymic size as judged radiographically. It is suggested that zinc deficiency may play a part in the thymic atrophy and infections associated with malnutrition.