RESUMO

Neutralizing activity of secretory immunoglobulin A (S-IgA) directed against the V1/V2 domain of HIV-1 was studied in parotid saliva of HIV-1- infected patients in Colombian and French cohorts. Purified V1/V2-specific S-IgA antibodies were found to neutralize clades A, B and C primary isolates in five out 76 and 82 patients from each cohort, respectively. These results suggest that neutralizing S-IgA antibodies targeting the V1/V2 domain may provide protection against HIV-1 infection in vivo and may be beneficial in mucosal vaccines.

Assuntos

Anticorpos Neutralizantes/imunologia , Infecções por HIV/imunologia , HIV-1/imunologia , Imunoglobulina A Secretora/imunologia , Saliva/imunologia , Estudos de Coortes , Colômbia , Feminino , França , Proteína gp120 do Envelope de HIV/imunologia , Humanos , Masculino , Fragmentos de Peptídeos/imunologia , Saliva/virologia