1.
J Labelled Comp Radiopharm
; 64(6): 237-242, 2021 05 30.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33665888
RESUMO
A copper-catalysed radiosynthesis of carbon-11 radiolabelled carboxylic acids was developed by reacting terminal alkynes and cyclotron-produced carbon-11 carbon dioxide ([11 C]CO2 ) in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU). A small library of 11 C-labelled propiolic acid derivatives were obtained with a total synthesis time of 15 min from end of bombardment (EOB) with a (non-isolated) radiochemical yield ranging from 7% to 28%.