1.
Curr Top Med Chem
; 19(22): 1962-1980, 2019.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31345151
RESUMO
Among the ophidians that inhabit the Northeast of Argentina, the genus Bothrops such as B. alternatus and B. diporus species (also known as yararás) and Crotalus durisus terrificus (named cascabel), represent the most studied snake venom for more than thirty years. These two genera of venomous snakes account for the majority of poisonous snake envenomations and therefore, constitute a medical emergency in this region. This review presents a broad description of the compiled knowledge about venomous snakebite: its pathophysiological action, protein composition, isolated toxins, toxin synergism, toxin-antitoxin cross-reaction assays. Properties of some isolated toxins support a potential pharmacological application.
Assuntos
Venenos de Serpentes/farmacologia , Toxinas Biológicas/farmacologia , Animais , Argentina , Bothrops , Crotalus , Humanos , Venenos de Serpentes/química , Venenos de Serpentes/isolamento & purificação , Toxinas Biológicas/química , Toxinas Biológicas/isolamento & purificação
2.
Int J Biol Macromol
; 113: 205-211, 2018 Jul 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29471097