1.
J Pediatr
; 127(2): 275-7, 1995 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-7636655
RESUMO
A woman receiving thyroxine substitution therapy for acquired hypothyroidism caused by autoimmune thyroiditis gave birth to three babies who had transient primary hypothyroidism. All three babies had elevated thyrotropin levels on neonatal screening, but one had normal thyroxine values. Thyrotropin receptor-blocking antibodies were present in maternal serum and in the three neonates. Each baby also had a different congenital malformation. The neurodevelopmental outcome of the children appeared related in part to maternal thyroxine levels, which suggests that transplacental transfer of thyroxine may protect the fetal brain.
Assuntos
Hipotireoidismo Congênito , Complicações na Gravidez/tratamento farmacológico , Tireoidite Autoimune/tratamento farmacológico , Tiroxina/sangue , Tiroxina/uso terapêutico , Adulto , Pré-Escolar , Feminino , Seguimentos , Cardiopatias Congênitas/epidemiologia , Hérnia Umbilical/epidemiologia , Humanos , Hipotireoidismo/epidemiologia , Recém-Nascido , Rim/anormalidades , Masculino , Gravidez , Complicações na Gravidez/sangue , Tireoidite Autoimune/sangue , Tireoidite Autoimune/complicações , Tireotropina/sangue , Fatores de Tempo
2.
Union Med Can
; 104(9): 1359-64, 1975 Sep.
Artigo
em Francês
| MEDLINE
| ID: mdl-1179539