RESUMO
High Altitude Pulmonary Edema (HAPE) generally appears in persons who climb over 2,500 meters (8,300 feet) above sea level, or in residents at altitudes beyond 3,000 meters (10,000 feet) who go down to sea level for a short period of time and return to their place of residence. Although dozens of cases have been reported, their etiopathogenesis is unknown, although both hydrostatic and permeability factors have been implied in its genesis. In this paper we describe the first HAPE case reported in the national literature and the factors implied in its physiopathology are reviewed.
Assuntos
Altitude , Edema Pulmonar/etiologia , Adulto , Humanos , Masculino , Edema Pulmonar/fisiopatologiaRESUMO
A case of glycogenosis type II infantile onset (Pompe's disease) is presented, and the literature is reviewed in order to establish the basis of the diagnostic suspect. We studied an 8-month old female with muscular weakness--and cardiac failure. The chest X-ray: cardiomegaly; electrocardiogram: PR interval of 0.06 seconds, gigant QRS complexes, biventricular hypertrophy, and the echocardiogram and cineangiography: left ventricle hypertrophy and hypokinesia. The patient died because of refractory heart failure. Histochemical examination demonstrated excessive intracellular accumulation of glycogen. Also, in the muscle, the kidneys and the liver we did not find any alpha 1,4 glucosidase. Then, the diagnosis of glycogenosis type II infantile onset was established. Finally, we conclude that this disease should be suspected in every infant with muscular weakness, cardiac failure, cardiomegaly, electrocardiogram with shortness of PR interval, gigant QRS complexes and biventricular hypertrophy, and that needs to be confirmed by muscle biopsy. At the moment, there has not been reported any case of Pompe's disease in the Mexican literature.