RESUMO
PURPOSE: Recently neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) have been reported to be inflammatory parameters that confer poorer outcome in metastatic castration-resistant prostate cancer (mCPRPC). However, these ratios have not been analyzed in patients treated with abiraterone acetate. We explored the relationship between different values of PLR and NLR and survival in mCPRCP treated with abiraterone and their possible relation with a prostate specific antigen (PSA) response. METHODS: We retrospectively analyzed 101 patients with mCRPC treated with abiraterone from January of 2012 to November of 2015 in two different hospitals. A cut-off value of 5 for NLR and 150 for PLR were used to compare survival by Kaplan-Meier method. Moreover, an association between these cut-off values and the PSA response was analyzed by a χ 2 test. RESULTS: In the case of NLR, the median DFS were 12, 1 months for NLR <5 and 7 months for NLR ≥5, p = 0.061. The median OS were 23.9 months for NLR <5 and 16.3 months for NLR ≥5, p = 0.046. In the case of PLR, the median DFS were 11.8 months for PLR <150 and 10.6 months for PLR ≥150, p = 0.549. The median OS were 27.4 months for PLR <150 and 15.9 months for PLR ≥150, p = 0.005. It was not observed a correlation between the different cut-off values of PLR or NLR and a PSA response ≥25% (p = 0.31). CONCLUSIONS: It is shown a better prognostic relationship between PLR and NLR low values and OS that is statistically significant in mCPRC patients treated with abiraterone. Furthermore, it was not shown a relation between PLR and NLR values and PSA response.
Assuntos
Acetato de Abiraterona/uso terapêutico , Antineoplásicos/uso terapêutico , Biomarcadores Tumorais/análise , Plaquetas/patologia , Linfócitos/patologia , Neutrófilos/patologia , Neoplasias de Próstata Resistentes à Castração/patologia , Idoso , Idoso de 80 Anos ou mais , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Prognóstico , Neoplasias de Próstata Resistentes à Castração/sangue , Neoplasias de Próstata Resistentes à Castração/tratamento farmacológico , Estudos Retrospectivos , Taxa de SobrevidaRESUMO
The aim of the current study was to determine the possible effects of progestagen oestrous synchronization on vascular endothelial growth factor (VEGF) expression during sheep luteogenesis and the peri-implantation period and the relationship with luteal function. At days 9, 11, 13, 15, 17 and 21 of pregnancy, the ovaries from 30 progestagen treated and 30 ewes cycling after cloprostenol injection were evaluated by ultrasonography and, thereafter, collected and processed for immunohistochemical evaluation of VEGF; blood samples were drawn for evaluating plasma progesterone. The progestagen-treated group showed smaller corpora lutea than cloprostenol-treated and lower progesterone secretion. The expression of VEGF in the luteal cells increased with time in the cloprostenol group, but not in the progestagen-treated group, which even showed a decrease between days 11 and 13. In progestagen-treated sheep, VEGF expression in granulosa-derived parenchymal lobule capillaries was correlated with the size of the luteal tissue, larger corpora lutea had higher expression, and tended to have a higher progesterone secretion. In conclusion, the current study indicates the existence of deleterious effects from exogenous progestagen treatments on progesterone secretion from induced corpora lutea, which correlate with alterations in the expression of VEGF in the luteal tissue and, this, presumably in the processes of neoangiogenesis and luteogenesis.
Assuntos
Corpo Lúteo/química , Corpo Lúteo/fisiologia , Progestinas/efeitos adversos , Ovinos , Fator A de Crescimento do Endotélio Vascular/análise , Animais , Corpo Lúteo/irrigação sanguínea , Implantação do Embrião/fisiologia , Sincronização do Estro , Feminino , Imuno-Histoquímica , Gravidez , Progesterona/sangueRESUMO
Although various progestagens are often used to induce and synchronize estrus and ovulation in ruminants, concerns regarding residues are the impetus to develop alternative approaches, including reduced doses of progestagens. Therefore, the objective was to determine whether ovarian function was affected by halving the dose of fluorogestone acetate in intravaginal sponges for synchronizing ovulation in sheep during the physiologic breeding season. Twenty Manchega ewes, 4-6-year-old, were randomly allocated to receive an intravaginal sponge containing either 20mg (P20, n=10) or 40 mg of fluorogestone acetate (P40, n=10). Cloprostenol (125 microg) was given at sponge insertion, and all sponges were removed after 6d. Ovarian follicular dynamics (monitored by daily ultrasonography) and other aspects of ovarian function did not differ significantly between the two groups. Ovulatory follicles (OF) grew at a similar growth rate (r=0.62; P<0.001), with comparable initial and maximum diameters (4.2+/-0.4 to 6.0+/-0.3mm in P20 vs. 4.6+/-0.6 to 5.7+/-0.2 mm in P40, mean+/-S.E.M.). Plasma estradiol concentrations (determined once daily) increased linearly during the 72 h interval after sponge removal (1.3+/-0.1 to 3.3+/-0.1 pg/mL for P20, P<0.005 and 1.4+/-0.1 to 3.1+/-0.2 pg/mL for P40, P<0.005). Ten days after sponge removal, ovulation rates (1.2+/-0.2 for P20 and 1.4+/-0.3 for P40), and plasma progesterone concentrations (3.8+/-0.35 ng/mL for P20 and 3.9+/-0.38 ng/mL for P40) were similar. In conclusion, reducing the dose of fluorogestone acetate from 40 to 20mg did not affect significantly ovarian follicular dynamics or other aspects of ovarian function.
Assuntos
Estradiol/sangue , Acetato de Fluorogestona/administração & dosagem , Acetato de Fluorogestona/farmacologia , Folículo Ovariano/fisiologia , Progesterona/sangue , Ovinos , Administração Intravaginal , Animais , Relação Dose-Resposta a Droga , Sincronização do Estro/métodos , FemininoRESUMO
In osteogenic sarcoma an increase in patient survival has been observed due to improvement of diagnostic and treatment methods. The objective of the investigation was to determine the usefulness of scintigraphy with 99mTc-MIBI in comparison to clinical revaluation, in order to assess tumor response (sarcoma) to chemotherapy previous to surgery. Patients with histopathological osteogenic sarcoma that received chemotherapy were included, clinical and scintigraphy response was assessed previous to the surgery. The gold standard for comparison was the degree necrosis histopathological analysis of the surgical specimen with measurement. Twelve patients met the inclusion criteria. A was observed a higher correlation between the 99mTc-MIBI and the histopathology. vs. clinical evaluation (0.89 vs. 0.59 respectively). Likewise the sensitivity (Se) and specificity (Sp) were superior (Se and Sp = 100% vs. Se 66.6% and Sp 75%) when therapeutically responses good and null were compared. We may conclude that scintigraphy with 99mTc-MIBI used to asses the response to presurgery chemotherapy in patients with osteogenic sarcoma, together with the clinical assessment, help the physician to make therapeutically decisions with more objectivity and certainly.
Assuntos
Neoplasias Ósseas/diagnóstico por imagem , Osteossarcoma/diagnóstico por imagem , Adolescente , Adulto , Antineoplásicos/uso terapêutico , Neoplasias Ósseas/tratamento farmacológico , Neoplasias Ósseas/patologia , Neoplasias Ósseas/cirurgia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Osteossarcoma/tratamento farmacológico , Osteossarcoma/patologia , Osteossarcoma/cirurgia , Valor Preditivo dos Testes , Cintilografia , Compostos Radiofarmacêuticos , Tecnécio Tc 99m SestamibiRESUMO
OBJECTIVE: Demonstrate the utility of centelleography using 111In-octreotide in carotid glomus simple o multiple in comparison to erythrocytes with 99mTc calculate the sensitivity, specificity and accuracy of both test. DESIGN: Comparative survey (Diagnostic test) Place: Hospital Oncológico de Concentración del Distrito Federal (Mexico). SUBJECTS: Twenty patients sent to nuclear medicine service for carotid glomus diagnosis. MAIN MEASURES: All of the patients went under a centelleography with 111In-octreotide labeled erythrocytes. Diagnostic was confirmed with US and CAT, taking as the gold standard the selective angiography and/or histopathology. RESULTS: Using 99mTc-labeled erythrocytes resulted in; True positives 13, true negatives 3, false positive 3, false negative 1. Sensitivity 92%, specificity 50%, accuracy 80% and Using 111In-octreotide: True positive 14, true negative 6, and 100% sensitivity, specificity was obtained. CONCLUSIONS: We consider that Centelleography with 111In-octreotide must be the selected image methodology to accurately diagnose carotid glomus, previous to surgery, or in case of patients prior to radiotherapy that because of age, damage size or location can not be candidates for surgery.
Assuntos
Tumor do Corpo Carotídeo/diagnóstico por imagem , Eritrócitos , Radioisótopos de Índio , Octreotida/análogos & derivados , Tecnécio , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Estudos Prospectivos , Cintilografia , Sensibilidade e EspecificidadeRESUMO
OBJECTIVE: To compare the efficacy of the breast scintigraphy with 99mTc-MIBI in the detection of breast lesions versus mammography. DESIGN: Cross sectional study. SETTING: A concentration oncologic hospital in Mexico City. PATIENTS: 56 women with a biopsy performed due to radiologic suspicion of mammary cancer were included as well as 10 normal women. MAIN PROCEDURES: Mammography, breast scintigraphy with 99mTc-MIBI, and biopsy were performed. RESULTS: Sensitivity of breast scintigraphy was 100% specificity 94.6%, PPV 90% and NPV 100%; sensitivity of the mammography was 100%, specificity 54% PPV 52.7%, and NPV 100%. CONCLUSIONS: Breast scintigraphy with 99mTc-MIBI showed a higher sensitivity and specificity than those of mammography. It was highly reliable for the diagnosis of mammary gland malignant lesions.
Assuntos
Neoplasias da Mama/diagnóstico por imagem , Mamografia , Tecnécio Tc 99m Sestamibi , Adulto , Idoso , Idoso de 80 Anos ou mais , Biópsia , Neoplasias da Mama/patologia , Estudos de Avaliação como Assunto , Feminino , Humanos , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Cintilografia , Sensibilidade e EspecificidadeRESUMO
Serial assessment of ventricular function by means of radionuclide angiography was performed in previously untreated patients with lymphoproliferative diseases who received either 4'epidoxorubicin or mitoxantrone for longer than 6 months. No changes were observed in left ventricular function in patients received mitoxantrone at doses ranged 90 to 165 mg (mean 113 mg). Three patients (7%) in 4'epidoxorubicin group showed less than or equal to 10% drop in left ventricular ejection, but without clinical manifestations. The doses in this group were 420 to 810 mg (mean 610 mg). We felt that patients without high-risk factors (radiotherapy to mediastinum or previously anthracycline therapy) could be treated with high doses of both drugs and that radionuclide angiography is a useful method for monitoring cardiotoxicity of antineoplastic drugs.