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1.
Appl Radiat Isot ; 200: 110964, 2023 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-37523865

RESUMO

Electronic cigarettes (e-cig) have gained popularity around the world and its health risks demands more research. This study aims at characterizing e-cig liquids (e-liquids) and its constituents by Total Reflection X-ray Spectrometry (TXRF). The internal standard method was the quantification procedure employed. The spectrometer's performance was evaluated with one certified reference material and spiked samples. It was possible to quantify K, Ca, Ti, Cr, Mn, Fe, Ni, Cu, Zn, Br, and Pb in the e-liquids. Concentrations above the limit for potable water were found in 10 out of 38 samples. Principal component analysis was useful for identifying toxic samples. TXRF is a promising technique for e-liquids evaluation due to its simplicity and performance.


Assuntos
Sistemas Eletrônicos de Liberação de Nicotina , Metais Pesados , Raios X , Espectrometria por Raios X/métodos , Metais/análise , Radiografia , Metais Pesados/análise , Monitoramento Ambiental/métodos
2.
Environ Sci Pollut Res Int ; 25(23): 22963-22976, 2018 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-29858996

RESUMO

This study investigated the action of titanium dioxide nanoparticles (TiO2-NPs), on the gills and kidneys of Neotropical freshwater fish, Prochilodus lineatus, with emphasis on reactive oxygen species (ROS) production, antioxidant responses, and morphological changes. Fish were exposed to 1, 5, 10, and 50 mg L-1 nominal TiO2-NPs suspended into water for 2 or 14 days. In gills, ROS decreased and glutathione (GSH) increased after 2 days, while ROS and GSH increased and superoxide dismutase activity decreased after 14 days. In kidneys, GSH and lipoperoxidation increased after 2 days and catalase activity decreased after 14 days. Common histopathologies in gills were epithelium hyperplasia, cellular hypertrophy, proliferation of mitochondria-rich cells (MRC), and lamellar stasis; in kidneys, there were cellular and nuclear hypertrophy, focal tubule degeneration, necrosis, and melanomacrophage (MM) proliferation. Although environmentally unlikely, high-dose exposures clarified biological effects of TiO2-NPs, such as ROS formation and MRC responses in the gills, which may impair ionic balance. It was also found that MM are likely responsible for eliminating NPs in the kidney. These findings will help to regulate TiO2-NP disposal, but longer-term studies are still needed.


Assuntos
Caraciformes/metabolismo , Ecotoxicologia/métodos , Biomarcadores Ambientais , Nanopartículas/toxicidade , Titânio/toxicidade , Poluentes Químicos da Água/toxicidade , Animais , Antioxidantes/análise , Antioxidantes/metabolismo , Água Doce , Brânquias/efeitos dos fármacos , Brânquias/metabolismo , Brânquias/patologia , Glutationa/análise , Glutationa/metabolismo , Rim/efeitos dos fármacos , Rim/metabolismo , Rim/patologia , Fígado/efeitos dos fármacos , Mitocôndrias/efeitos dos fármacos , Mitocôndrias/patologia , Nanopartículas/química , Espécies Reativas de Oxigênio/análise , Espécies Reativas de Oxigênio/metabolismo , Testes de Toxicidade Aguda , Poluentes Químicos da Água/química
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