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AIMS: In this study, we examined the relationship between 131 suicide related Google search terms, grouped into nine categories, and the number of suicide cases per month in Ecuador from January 2011 to December 2021. METHODS: First, we applied time-series analysis to eliminate autocorrelation and seasonal patterns to prevent spurious correlations. Second, we used Pearson's correlation to assess the relationship between Google search terms and suicide rates. Third, cross-correlation analysis was used to explore the potential delayed effects between these variables. Fourth, we extended the correlation and cross-correlation analyses by three demographic characteristics - gender, age, and region. RESULTS: Significant correlations were found in all categories between Google search trends and suicide rates in Ecuador, with predominantly positive and moderate correlations. The terms 'stress' (.548), 'prevention' (.438), and 'disorders' (.435) showed the strongest associations. While global trends indicated moderate correlations, sensitivity analysis revealed higher coefficients in men, young adults, and the Highlands region. Specific patterns emerged in subgroups, such as 'digital violence' showing significant correlations in certain demographics, and 'trauma' presenting a unique temporal pattern in women. In general, cross correlation analysis showed an average negative correlation of -.191 at lag 3. CONCLUSION: Google search data do not provide further information about users, such as demographics or mental health records. Hence, our results are simply correlations and should not be interpreted as causal effects. Our findings highlight a need for tailored suicide prevention strategies that recognize the complex dynamics of suicide risk across demographics and time periods.
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Introducción: La seguridad alimentaria es uno de los objetivos principales a lograr por parte de las autoridades en Ecuador. Se describe que la inseguridad alimentaria es un elemento facilitador de estados displacenteros en la población que generan elevados niveles de ansiedad y depresión. Objetivo: Describir el comportamiento de la seguridad alimentaria y los niveles de ansiedad en productores de quinua de la provincia Chimborazo. Métodos: Se realizó una investigación básica, con diseño no experimental, de campo, transversal y descriptivo que incluyó como población de estudio a los 410 productores de quínoa del cantón Colta en la provincia Chimborazo, Ecuador. La muestra quedó conformada por 210 agricultores. Se utilizó la Escala Latinoamericana y Caribeña de Seguridad Alimentaria para determinar la seguridad alimentaria y la escala de ansiedad de Hamilton para identificar los niveles de ansiedad. Resultados: Se obtuvo un promedio de edad de 56,67 años, predominaron las agricultoras femeninas (60,95 por ciento) y la no referencia de nivel de instrucción (46,19 por ciento). El 56,67por ciento de los agricultores mostró inseguridad alimentaria predominando el nivel ligero (73,95 por ciento). La ansiedad fue identificada en el 45,24 por ciento de los agricultores con predominio de la ansiedad ligera (82,11 por ciento). La ansiedad estuvo presente en el 57,98 por ciento de los agricultores con inseguridad alimentaria y en el 28,57 por ciento de los que presentaron seguridad alimentaria. Conclusiones: Se identificaron elevados porcentajes de agricultores con inseguridad alimentaria y ansiedad. Esta última alcanzó mayor porcentaje en agricultores con inseguridad alimentaria(AU)
Introduction: Food security is one of the main goals to be achieved by the authorities in Ecuador. For its part, it is described that food insecurity is a facilitator of unpleasant states in the population, generating high levels of anxiety and depression. Objective: To describe the behavior of food security and anxiety levels in quinoa producers in the Chimborazo province. Methods: A basic research was carried out, with a non-experimental, field, cross-sectional and descriptive design that included as a study population the 410-quinoa producers of the Colta canton in the Chimborazo province, Ecuador. The sample was made up of 210 farmers. The Latin American and Caribbean Food Security Scale was used to determine food security and the Hamilton Anxiety Scale to identify anxiety levels. Results: an average age of 56.67 years was obtained, female farmers predominated (60.95 percent) and the non-reference level of education (46.19 percent). 56.67 percent of the farmers showed food insecurity, predominating the light level (73.95 percent). Anxiety was identified in 45.24 percent of the farmers with a predominance of light anxiety (82.11 percent). Anxiety was present in 57.98 percent of the farmers with food insecurity and in 28.57 percent of those with food security. Conclusions: High percentages of farmers with food insecurity and anxiety were identified. The latter reached the highest percentage in food insecure farmers(AU)
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Humanos , EquadorRESUMO
RESUMEN Introducción: Lograr la seguridad alimentaria de la población es el mayor reto alimentario en la actualidad. A pesar de los esfuerzos realizados aún esta distante esta meta, sobre todo en las comunidades rurales. La inseguridad alimentaria es considerada un elemento que condiciona afectación psicológica en la población. Objetivo: Determinar las características de la seguridad alimentaria en población rural de la provincia Chimborazo y la presencia de manifestaciones psicológicas relacionadas. Métodos: Se realizó una investigación no experimental, de campo, transversal y descriptiva que incluyó una población de 410 productores de quínoa del cantón Colta. La muestra quedó conformada por 210 agricultores. Se utilizó la Escala Latinoamericana y Caribeña de Seguridad Alimentaria para determinar la seguridad alimentaria y la Escala de Ansiedad de Hamilton para identificar presencia de esta afección. Resultados: Promedio de edad de 56,67 años con desviación estándar de 36,38; predominio de agricultoras femeninas (60,95 %) y de personas sin nivel de instrucción (46,19 %). El 56,67 % de los agricultores mostró inseguridad alimentaria; predominó el nivel ligero (73,95 %). La ansiedad fue identificada en el 45,24 % de los agricultores con predominio de la ansiedad ligera (82,11 %). La ansiedad estuvo presente en el 57,98 % de los agricultores con inseguridad alimentaria y en el 28,57 % de los que presentaron seguridad alimentaria. Conclusiones: Existen elevados porcentajes de agricultores con inseguridad alimentaria y ansiedad. Esta última alcanzó mayor porcentaje en agricultores con inseguridad alimentaria.
ABSTRACT Introduction: Achieving food security for the population is perhaps the greatest food challenge today. Despite the efforts made, this goal is still distant, especially in rural communities. Food insecurity is considered as an element that conditions psychological affectation in the population. Objective: To determine the characteristics of food security in the rural population of the Chimborazo province and the presence of related psychological manifestations. Method: Non-experimental, field, cross-sectional and descriptive research was carried out that included a population of 410 quinoa producers from the Colta canton. The sample was made up of 210 farmers. The Latin American and Caribbean Food Safety Scale was used to determine food safety and the Hamilton Anxiety Scale to identify the presence of this condition. Results: Average age of 56.67 years with standard deviation of 36.38; predominance of female farmers (60.95 %) and people with no level of education (46.19 %); 56.67 % of the farmers showed food insecurity, predominantly the light level (73.95 %). Anxiety was identified in 45.24 % of farmers with a predominance of mild anxiety (82.11 %). Anxiety was present in 57.98 % of farmers with food insecurity and in 28.57 % of those with food security. Conclusions: High percentages of farmers with food insecurity and anxiety were identified. The latter reached the highest percentage in food insecure farmers.
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RESUMEN Introducción: La seguridad alimentaria es un amplio concepto que incluye múltiples factores que de una forma u otra inciden en que la población pueda acceder a una alimentación de calidad. Solo de esta forma se podrá cumplir con la ansiada meta de disponer de una alimentación saludable que no solo permita minimizar la aparición de enfermedades, sino que también contribuya a controlar las ya existentes. Objetivo: Determinar el comportamiento de la seguridad alimentaria en la población rural del cantón Colta, provincia de Chimborazo, Ecuador. Métodos: Investigación básica, de campo, descriptiva y de corte transversal realizada en el cantón Colta, provincia Chimborazo, con una población total de 410 familias dedicadas al cultivo de la quínoa. La muestra quedó conformada por 210 agricultores. Se utilizó la Escala Latinoamericana y Caribeña de Seguridad Alimentaria para determinar la seguridad alimentaria y sus elementos relacionados. Resultados: En el 56,67 % de las familias se identificó inseguridad alimentaria; y fue más significativa en familias con menores de 18 años (66,67 %). Predominó la inseguridad alimentaria ligera (73,95 %). La falta de recursos económicos (86,55 %), el elevado costo de los alimentos (76,49 %), los problemas relacionados con el acceso físico a los alimentos (74,79 %) y la inadecuada cobertura de salud (74,79 %) fueron las determinantes más referidas como causa de inseguridad alimentaria. Conclusiones: El elevado porcentaje de inseguridad alimentaria fue más predominante en las familias con personas menores de 18 años dentro de su composición familiar. Los elementos relacionados con el tema económico fueron los más referenciados como condicionantes de inseguridad alimentaria.
ABSTRACT Introduction: Food security is a broad concept that includes multiple factors that in one way or another affect the population's access to quality food. Only in this way will it be possible to meet the long-awaited goal of having a healthy diet that not only minimizes the appearance of diseases, but also helps to control existing ones. Objective: To determine the behavior of food security in the rural population of the Colta canton, Chimborazo province, Ecuador. Methods: Basic, field, descriptive and cross-sectional research carried out in the Colta canton, Chimborazo province, with a total population of 410 families dedicated to the cultivation of quinoa. The sample was made up of 210 farmers. The Latin American and Caribbean Food Security Scale was used to determine food security and its related elements. Results: In 56.67% of the families food insecurity was identified; being more significant in families with children under 18 years of age (66.67%). Slight food insecurity predominated (73.95%). The lack of economic resources (86.55%), the high cost of food (76.49%), problems related to physical access to food (74.79%) and inadequate health coverage (74, 79%) were the determinants most referred to as a cause of food insecurity. Conclusions: The high percentage of food insecurity was more prevalent in families with people under 18 years of age within their family composition. The elements related to the economic issue were the most referenced as determinants of food insecurity.
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HumanosRESUMO
Casi dos años después de que se impuso la adecuación del trabajo docente a la modalidad remota, la política pública educativa no visualiza en su discurso actual la atención al tecnoestrés docente como prioridad y no existen acciones concretas encaminadas en ese sentido. Se realizó un estudio cuantitativo, observacional, descriptivo y correlacional en tres colegios fiscales, a fin de obtener información sobre la prevalencia de tecnoestrés en docentes y aportar evidencia empírica acerca de las diferencias entre ambos sexos, en cuanto a algunos factores asociados a este. Los resultados tecnoestrés en los y las docentes participantes, independientemente a la edad, sexo y años de experiencias y correlacionado con la sobre carga tecnológica, la intensidad de trabajo diario, tecno-invasión y las consecuencias socioemocionales al trabajar fuera el horario laboral, en contexto COVID-19 y, como consecuencias impacto negativo en su bienestar psicológicos; los datos aportados sugieren implicancias interesantes del uso de las TICs que se extienden más allá de lo educativo y lo tecnológico, alcanzando además los campos: social, salud ocupacional y psicológico. Por lo que se recomienda seguir realizando investicaciones acerca de este fenómeno durante y post COVID-19(AU)
Almost two years after the adaptation of teaching work to the remote modality was imposed, the educational public policy does not visualize in its current discourse the attention to teaching techno-stress as a priority and there are no concrete actions directed in that direction. A quantitative, observational, descriptive and correlational study was carried out in three public schools, in order to obtain information on the prevalence of technostress in teachers and provide empirical evidence about the differences between the sexes, in terms of some factors associated with it. The results of techno-stress in the participating teachers, regardless of age, sex and years of experience and correlated with technological overload, intensity of daily work, techno-invasion and the socio-emotional consequences of working outside working hours, in context COVID-19 and, as consequences, a negative impact on their psychological well-being; the data provided suggest interesting implications of the use of ICTs that extend beyond education and technology, also reaching the fields: social, occupational health and psychological. Therefore, it is recommended to continue conducting research on this phenomenon during and after COVID-19(AU)
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Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Educação a Distância , Docentes , Estresse Ocupacional , Teletrabalho , COVID-19 , Instituições Acadêmicas , Ensino , Tecnologia , Tecnologia da InformaçãoRESUMO
Resumen: Objetivo general: Determinar la incidencia de la trombosis venosa (TV) e infección asociada con el catéter central de inserción periférica (PICC). Material y métodos: Se realizó un estudio retrospectivo, replicativo y descriptivo, cuya duración fue de 38 meses. Los catéteres centrales de inserción periférica se colocaron por el Servicio de Radiología Intervencionista con la misma técnica en las extremidades superiores. Se guardó una imagen del procedimiento con el nombre y diámetro de la vena usada. En el estudio se incluyó a partir del primer catéter PICC colocado en marzo de 2015 hasta el último en abril de 2018. Se registraron las trombosis venosas demostradas por ultrasonido Doppler, la duración del catéter y las bacteriemias relacionadas con el PICC (BRC-PICC). Resultados: Se colocaron 448 PICC y, de éstos, se excluyeron 78. Los 370 catéteres restantes sumaron 3,363 días-catéter. El 99.45% de los procedimientos resultaron exitosos. La incidencia de trombosis encontrada fue de 0.016% (n = 6) y la de infección de 0.03% (n = 12). El vaso más frecuentemente utilizado fue la vena basílica derecha. Conclusiones: La incidencia tanto de trombosis como de infección se mantiene por debajo de las reportadas en la literatura. Las venas mayores a 3.8 mm de diámetro tienen una probabilidad muy baja de presentar trombosis venosa.
Abstract: Objective: To determine the incidence of venous thrombosis (VT) and infection associated with PICC lines. Material and methods: A retrospective, replicative and descriptive study was conducted over 38 months. The PICC line was inserted in the upper extremities by the Interventional Radiology Service with the same technique. An image of the procedure with the name and diameter of the selected vein was saved. Venous thrombosis, demonstrated by Doppler ultrasound, the duration of the catheter and bacteremia related to the PICC line (BRC-PICC) were recorded. Results: 448 PICCs were placed and 78 were excluded. The remaining 370 catheters added 3,363 catheter days. 99.45% of the procedures were technically successful. The incidence of thrombosis was 0.016% (n = 6) and that of infection 0.03% (n = 12). The most frequently selected vessel was the right basilic vein. Conclusions: The incidence of thrombosis and infection were below the reported in the literature. Veins greater than 3.8 mm have a very low probability of having TV.
Resumo: Objetivo: Determinar a incidência de trombose venosa (TV) e infecção associada ao PICC. Material e métodos: Foi realizado um estudo retrospectivo, replicativo e descritivo, durante 38 meses. Os cateteres PICC foram colocados nas extremidades superiores pelo serviço de Radiologia Intervencionista com a mesma técnica. Guardou-se uma imagem do procedimento com o nome e o diâmetro da veia utilizada. Incluíu-se desde o primeiro cateter PICC colocado em março de 2015 até abril de 2018. Registraram-se as tromboses venosas por ultrassom Doppler, duração do cateter e bacteremias relacionadas ao PICC (BRC-PICC). Resultados: Colocaram-se 448 PICC e foram excluídos 78. Os 370 cateteres restantes somaram 3363 dias de cateter. 99.45% dos procedimentos foram bem sucedidos. A incidência de trombose encontrada foi de 0.016% (n = 6) e a de infecção de 0.03% (n = 12). O vaso mais utilizado foi a veia basílica direita. Conclusões: A incidência de trombose e infecção permanece abaixo da relatada na literatura. Veias com diâmetro superior a 3.8 mm têm uma probabilidade muito baixa de apresentar trombose venosa.
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Hepatic artery thrombosis is the most frequent vascular complication following orthotopic liver transplantation, and often results in biliary complications, early graft loss and death. Surgical revascularization and retransplantation are considered the mainstay of treatment. However, intraarterial endovascular therapy is an alternative that has shown low morbidity and mortality, thereby avoiding the need for retransplantation. We describe a case of orthotopic liver transplantation complicated with hepatic artery thrombosis that was successfully treated with endovascular therapy.
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Introduction: In Head and Neck (HN) cancer, the High-Risk Human Papillomavirus (hr HPV) infection has been associated in about 40% of these tumors. The hr HPV infection is one of the etiological factors of several epithelial tumors; however, its association with the prognosis has not yet been established for patients with Laryngeal Squamous Cell Carcinoma (LSCC). On the other hand, Epidermal Growth Factor Receptor (EGFR) is a molecular marker widely studied in cancer and its overexpression has been associated with poor prognosis in some types of cancer, including the HN cancer. In the present study, we analyzed EGFR expression and HPV detection in a cohort of Mexican patients with LSCC and define their association with clinical-pathological and survival parameters. Methods: EGFR expression analysis was performed by immunohistochemistry assay. A tissue array was constructed based on 30 paraffin-embedded tissue samples. HPV detection was performed by PCR. The results were then compared with the clinical-pathological variables and outcome measures (Kaplan Meier and Cox analysis). Results: High expression of EGFR was observed in 43% of the samples and 20% of HPV detection. The statistical analyses provided evidence of disassociation between clinical-pathological parameters and EGFR expression, but there was an association with poor prognosis. Interestingly, HPV detection is slightly associated with good prognosis. Conclusion: Both, EGFR overexpression and HPV presence could be associated with an unfavorable prognosis in patients with LSCC, independently of other clinical-pathological factors.
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Carcinoma de Células Escamosas/mortalidade , Neoplasias Laríngeas/mortalidade , Infecções por Papillomavirus/mortalidade , Carcinoma de Células Escamosas/patologia , Carcinoma de Células Escamosas/virologia , DNA Viral/genética , Receptores ErbB/metabolismo , Feminino , Seguimentos , Humanos , Neoplasias Laríngeas/patologia , Neoplasias Laríngeas/virologia , Masculino , México , Pessoa de Meia-Idade , Papillomaviridae/genética , Papillomaviridae/isolamento & purificação , Infecções por Papillomavirus/patologia , Infecções por Papillomavirus/virologia , Prognóstico , Taxa de SobrevidaRESUMO
Arterial hypertension is a highly manageable disorder due to a variety of drugs available for its treatment. Since the late 1990s, angiotensin II receptor blockers have been widely prescribed, achieving appropriate control in patients' blood pressure. Few cases of serious adverse effects have been reported to date. Here, we present a case of acute hepatocellular injury secondary to candesartan administration. Further studies should be performed in patients who present with this adverse effect, in order to prevent more serious outcomes.
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Bloqueadores do Receptor Tipo 1 de Angiotensina II/efeitos adversos , Anti-Hipertensivos/uso terapêutico , Benzimidazóis/efeitos adversos , Doença Hepática Induzida por Substâncias e Drogas/diagnóstico , Hipertensão/tratamento farmacológico , Tetrazóis/efeitos adversos , Adulto , Anlodipino/uso terapêutico , Bloqueadores do Receptor Tipo 1 de Angiotensina II/administração & dosagem , Benzimidazóis/administração & dosagem , Compostos de Bifenilo , Pressão Sanguínea/efeitos dos fármacos , Doença Hepática Induzida por Substâncias e Drogas/sangue , Doença Hepática Induzida por Substâncias e Drogas/etiologia , Relação Dose-Resposta a Droga , Humanos , Hipertensão/sangue , Testes de Função Hepática , Masculino , Tetrazóis/administração & dosagemRESUMO
BACKGROUND: Small cell carcinoma of the urinary bladder is an infrequent lesion. CLINICAL CASE: We present the case of a 68-year-old male who arrived at the emergency room with a history of 24-h gross hematuria. Imaging studies show a urinary bladder tumor with a 218 cc volume that during a 20-day period increased to 426 cc. Histopathological images with hematoxylin-eosin show an infiltrating solid mass with uneven borders. It is composed of neoplastic cells with evident nuclei predominance and scant cytoplasm (small cells). Chromogranin immunohistochemical staining shows a diffusely positive cytoplasmic granular pattern on neoplastic cells. High molecular weight cytokeratin staining shows a negative pattern on neoplastic cells along with a positive pattern on reporsurrounding normal urothelium. Tumoral mass is positive for synaptophysin and CD-56 and negative for CK-7 and CK-20. Patient therapy was based on radiation plus chemotherapy. CONCLUSION: Small cell carcinoma of the urinary bladder represents 0.35-0.70% of urinary bladder tumors. Histological and immunohistochemical identification are key elements in the diagnosis. Treatment approach is based on cisplatin-based chemotherapy plus radical cystectomy, except when metastatic disease is present.
Antecedentes: el carcinoma neuroendocrino de células pequeñas primario de vejiga es una lesión maligna muy poco frecuente. Caso clínico: paciente masculino de 68 años de edad, que tuvo hematuria macroscópica de 24 horas de evolución. Estudios de imagen mostraron tumoración vesical de 218 cc, que en 20 días alcanzó un volumen de 426 cc. A la tinción con hematoxilina-eosina, histológicamente se apreció: placa sólida infiltrante de bordes irregulares, compuesta por células neoplásicas con claro predominio de núcleo y escaso citoplasma (células pequeñas). A la tinción inmunohistoquímica con cromogranina parecía difusamente positivo en células neoplásicas, en un patrón granular citoplasmático. A la tinción con citoqueratina de alto peso molecular se observó patrón negativo en células neoplásicas con control interno positivo en el urotelio acompañante en espécimen. De igual manera, la tumoración fue positiva para sinaptofisina y CD-56 y negativa para CK-7 y CK-20. El paciente recibió tratamiento a base de radioterapia y quimioterapia. Conclusión: el carcinoma neuroendocrino de células pequeñas primario de vejiga representa de 0.35 a 0.70% de los tumores vesicales primarios. Su diagnóstico se basa en el reconocimiento histológico e inmunohistoquímico. El tratamiento se fundamenta en quimioterapia con cisplatino más cistectomía radical, excepto cuando existe enfermedad metastásica.
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Carcinoma Neuroendócrino/patologia , Carcinoma de Células Pequenas/patologia , Neoplasias da Bexiga Urinária/patologia , Idoso , Biomarcadores Tumorais/análise , Antígeno CD56/análise , Carcinoma Neuroendócrino/química , Carcinoma de Células Pequenas/complicações , Cromograninas/análise , Evolução Fatal , Hematúria/etiologia , Humanos , Queratinas/análise , Masculino , Sinaptofisina/análise , Tomografia Computadorizada por Raios X , Neoplasias da Bexiga Urinária/químicaRESUMO
AIMS: The authors have previously reported that cellular retinol-binding protein 1 (CRBP1) gene gain and its expression correlated significantly with survival in laryngeal carcinoma patients. The authors hypothesised that inactivation of the CRBP1 gene through CpG methylation is associated with patient status and gene expression. In this work, the authors determine the expression and methylation status of the CRBP1 gene and its correlation with clinical variables of laryngeal carcinoma patients. METHODS: The CRBP1 gene methylation promoter was assessed by methylation specific PCR analysis in tissue samples from larynx cancer specimens and its expression was assessed by immunohistochemistry on paraffin embedded tissue using tissue microarray. The results were then compared with the clinical pathological variables and outcome measures. The study included 46 samples from patients with non-metastatic squamous cell carcinoma of the larynx without any previous oncological treatments. RESULTS: Lack of CRBP1 expression was seen in 17 of the 46 laryngeal carcinoma samples, while the remaining 29 samples showed increased expression. Significant associations were found between CRBP1 expression and methylation and patient status. There was a tendency for association in all clinical stages of the disease. CRBP1 gene expression and its unmethylated promoter correlated significantly with survival (p<0.05). CONCLUSIONS: An early event of larynx cancer could be CRBP1 expression related to unmethylation of the promoter region. These features could also be associated with good response and survival. The authors hypothesised that increased expression and unmethylated promoter of the CRBP1 gene could be considered as markers for larynx cancer.
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Biomarcadores Tumorais/genética , Carcinoma de Células Escamosas/genética , Metilação de DNA , Neoplasias Laríngeas/genética , Proteínas Celulares de Ligação ao Retinol/genética , Biomarcadores Tumorais/análise , Carcinoma de Células Escamosas/química , Carcinoma de Células Escamosas/mortalidade , Carcinoma de Células Escamosas/patologia , Distribuição de Qui-Quadrado , Feminino , Células HeLa , Células Hep G2 , Humanos , Imuno-Histoquímica , Estimativa de Kaplan-Meier , Neoplasias Laríngeas/química , Neoplasias Laríngeas/mortalidade , Neoplasias Laríngeas/patologia , Masculino , México , Pessoa de Meia-Idade , Reação em Cadeia da Polimerase , Prognóstico , Regiões Promotoras Genéticas , Proteínas Celulares de Ligação ao Retinol/análise , Taxa de Sobrevida , Fatores de Tempo , Análise Serial de TecidosRESUMO
PURPOSE: To investigate the genomic alterations in larynx carcinomas (LaCa) tissues and its prognostics values in predicting survival. METHODS: To analyse the aberrations in the genome of LaCa patients, we used array comparative genomic hybridization in 19 human laryngeal tumour samples. DNA samples were also subjected to detect human papillomavirus (HPV) sequences by polymerase chain reaction (PCR). Copy number gain was confirmed by real-time PCR. The cellular retinol-binding protein 1 (CRBP-1) gene expression was also confirmed by immunohistochemistry assay on LaCa tissues. To identify prognostic feature, CRBP-1 gene gain was correlated to patient survival. RESULTS: The most common gains were detected for CRBP-1 and EGFR genes, while DNA lost in RAF-1 gene. Immunohistochemistry assay was revealed strong expression of CRBP1 protein in those cases with CRBP-1 gene gain. The CRBP-1 gene gain and its expression correlated significantly with survival (P = 0.003). Cox regression analysis indicated that CRBP-1 expression level was a factor of survival (P = 0.008). HPV sequences were detected in 42% of the samples, and did not show any relationship with specific gene alterations. CONCLUSION: Our data shows that CRBP-1 gene gain can be determined by immunohistochemistry on routinely processed tissue specimens, and could support as a potential novel marker for long-term survival in laryngeal squamous cell carcinoma.
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Biomarcadores Tumorais/metabolismo , Carcinoma de Células Escamosas/metabolismo , Proteínas do Olho/metabolismo , Neoplasias Laríngeas/metabolismo , Proteínas de Membrana/metabolismo , Proteínas do Tecido Nervoso/metabolismo , Idoso , Carcinoma de Células Escamosas/mortalidade , Hibridização Genômica Comparativa , Receptores ErbB/metabolismo , Feminino , Regulação Neoplásica da Expressão Gênica , Humanos , Imuno-Histoquímica , Neoplasias Laríngeas/mortalidade , Metástase Linfática , Masculino , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Valor Preditivo dos Testes , Prognóstico , Modelos de Riscos Proporcionais , Análise de Sobrevida , Regulação para CimaRESUMO
Sarcomas constitute 5% of all of head and neck neoplasms. Angiosarcomas comprise 2% of all soft tissue tumors, 60% appear in skin and soft tissue, 50% in the head and neck and only 4% are present in the upper aerodigestive tract. We report a case of a 52 year old healthy woman with headache, weeping, foreign body sensation in the left nostril and epixtasis. The TAC identified a tumor in the left nostril that invaded the osseous lamina of the skull. The histopathologic diagnosis was angiosarcoma. We carried out a literature review and analysis from 1976 to 2004. Agiosarcomas of the upper aerodigestive tract have a better prognosis and long term survival free of disease than their soft tissue and skin counterparts. Recurrence is strongly correlated with positive resection margins. Complete surgery and radiotherapy are considered the optimal treatment schemes.
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Hemangiossarcoma/diagnóstico , Cavidade Nasal , Neoplasias Nasais/diagnóstico , Feminino , Humanos , Pessoa de Meia-IdadeRESUMO
Los sarcomas de la cabeza y cuello son raros sólo 5% de todos los sarcomas aparecen en esta región. El angiosarcoma es una neoplasia que representa 2% de todos los tumores de tejidos blandos, 60% ocurren en la piel y tejidos blandos, 50% en la región de la cabeza y cuello y entre estos últimos sólo 4% de los casos en el tracto aereodigestivo superior. Se informa el caso de una mujer de 52 años con cefalea, lagrimeo, sensación de cuerpo extraño en fosa nasal izquierda y epistaxis. En la TAC se identificó un tumor en fosa nasal izquierda que invadía hasta la lámina ósea del cráneo. El informe histopatológico fue de angiosarcoma. Se revisaron y analizaron los casos informados en la literatura desde el año 1976 al 2004. Se concluye que los angiosarcomas del tracto aereodigestivo superior tienen un mejor pronóstico con mayor supervivencia sin enfermedad, en comparación a los de la piel o tejidos blandos. La recurrencia se relaciona estrechamente con la positividad de los márgenes quirúrgicos. El tratamiento es a base de la resección quirúrgica completa con radioterapia.
Sarcomas constitute 5% of all of head and neck neoplasms. Angiosarcomas comprise 2% of all soft tissue tumors, 60% appear in skin and soft tissue, 50% in the head and neck and only 4% are present in the upper aerodigestive tract. We report a case of a 52 year old healthy woman with headache, weeping, foreign body sensation in the left nostril and epixtasis. The TAC identified a tumor in the left nostril that invaded the osseous lamina of the skull. The histopathologic diagnosis was angiosarcoma. We carried out a literature review and analysis from 1976 to 2004. Agiosarcomas of the upper aerodigestive tract have a better prognosis and long term survival free of disease than their soft tissue and skin counterparts. Recurrence is strongly correlated with positive resection margins. Complete surgery and radiotherapy are considered the optimal treatment schemes.