RESUMO
INTRODUCTION: Seizures are a common neurological problem in the pediatric population, and their etiologies in certain developing countries are still not clear. From previous studies it is well known that neurocysticercosis is the main cause of partial seizures in the adult population in Peru and in many developing countries, but the situation has not been clarified for the paediatric population yet. PATIENTS AND METHODS: Fifty-four consecutive patients in pre- and school ages, with partial seizures, were evaluated in the outpatient clinics and emergency room of a public hospital in Lima. Evaluation consisted in clinical exam, computed tomography of the head, and in some cases serological evaluation. RESULTS: Thirty-seven percent were diagnosed with neurocysticercosis, which was found to be the main cause. CONCLUSIONS: The possible explanations may be the high incidence of neurocysticercosis in Peru, and the fact that epilepsy and seizures are the most common clinical manifestation of neurocysticercosis in children. These findings are also representative of the current situation in gravel developing countries.
Assuntos
Neurocisticercose/complicações , Neurocisticercose/fisiopatologia , Convulsões/etiologia , Adolescente , Adulto , Criança , Pré-Escolar , Humanos , Masculino , Neurocisticercose/diagnóstico , Neurocisticercose/epidemiologia , Peru/epidemiologia , Convulsões/epidemiologiaRESUMO
The objective of this study was to investigate the role of menopause in the appearance of the physiopathological sequence that leads to chronic mountain sickness (CMS) in a high-altitude female population. The females studied are 30-54 yr old (n = 152) and have permanent residence in Cerro de Pasco (Pasco, Peru; 4,300 m). The sample was divided into postmenopausal and premenopausal groups for comparison. Blood oxygen saturation (SaO2), excessive erythrocytosis [EE, measured by the level of hematocrit (Het)], peak expiratory flow rates (PEFR), and a score that represents the main signs and symptoms of CMS (CMSscore) were measured. Postmenopausal women had higher Het (50.2 +/- 4.04 vs. 47.4 +/- 4.13%, P < 0.001), lower SaO2 (81.9 +/- 4.12 vs. 84.7 +/- 3.14%, P < 0.001) and PEFR values (489 +/- 101 vs. 534 +/- 90 l/min, P < 0.02), and slightly higher CMSscore (19.1 +/- 3.37 vs. 17.9 +/- 3.48, P < 0.06) than premenopausal women. The prevalence of women with EE (EE = Hct > 56%) was found to be 8.8%. Forty-five percent of the postmenopausal subjects presented a high CMSscore (> 21), whereas only 22% of the premenopausal subjects presented this high value (P < 0.02). We can therefore conclude that menopause may represent a contributing factor for the development of CMS.