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2.
CA Cancer J Clin ; 68(3): 199-216, 2018 05.
Artigo em Inglês | MEDLINE | ID: mdl-29603147

RESUMO

Timely follow-up for positive cancer screening results remains suboptimal, and the evidence base to inform decisions on optimizing the timeliness of diagnostic testing is unclear. This systematic review evaluated published studies regarding time to follow-up after a positive screening for breast, cervical, colorectal, and lung cancers. The quality of available evidence was very low or low across cancers, with potential attenuated or reversed associations from confounding by indication in most studies. Overall, evidence suggested that the risk for poorer cancer outcomes rises with longer wait times that vary within and across cancer types, which supports performing diagnostic testing as soon as feasible after the positive result, but evidence for specific time targets is limited. Within these limitations, we provide our opinion on cancer-specific recommendations for times to follow-up and how existing guidelines relate to the current evidence. Thresholds set should consider patient worry, potential for loss to follow-up with prolonged wait times, and available resources. Research is needed to better guide the timeliness of diagnostic follow-up, including considerations for patient preferences and existing barriers, while addressing methodological weaknesses. Research is also needed to identify effective interventions for reducing wait times for diagnostic testing, particularly in underserved or low-resource settings. CA Cancer J Clin 2018;68:199-216. © 2018 American Cancer Society.


Assuntos
Continuidade da Assistência ao Paciente , Detecção Precoce de Câncer , Neoplasias/diagnóstico , Biópsia , Diagnóstico Tardio , Diagnóstico por Imagem , Humanos , Tempo para o Tratamento
3.
Chest ; 141(1): 20-26, 2012 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-21940766

RESUMO

BACKGROUND: Recently studied therapies for pulmonary arterial hypertension (PAH) have improved outcomes among populations of patients, but little is known about which patients are most likely to respond to specific treatments. Differences in endothelin-1 biology between sexes and between whites and blacks may lead to differences in patients' responses to treatment with endothelin receptor antagonists (ERAs). METHODS: We conducted pooled analyses of deidentified, patient-level data from six randomized placebo-controlled trials of ERAs submitted to the US Food and Drug Administration to elucidate heterogeneity in treatment response. We estimated the interaction between treatment assignment (ERA vs placebo) and sex and between treatment and white or black race in terms of the change in 6-min walk distance from baseline to 12 weeks. RESULTS: Trials included 1,130 participants with a mean age of 49 years; 21% were men, 74% were white, and 6% were black. The placebo-adjusted response to ERAs was 29.7 m (95% CI, 3.7-55.7 m) greater in women than in men (P = .03). The placebo-adjusted response was 42.2 m for whites and -1.4 m for blacks, a difference of 43.6 m (95% CI, -3.5-90.7 m) (P = .07). Similar results were found in sensitivity analyses and in secondary analyses using the outcome of absolute distance walked. CONCLUSIONS: Women with PAH obtain greater responses to ERAs than do men, and whites may experience a greater treatment benefit than do blacks. This heterogeneity in treatment-response may reflect pathophysiologic differences between sexes and races or distinct disease phenotypes.


Assuntos
Anti-Hipertensivos/uso terapêutico , Antagonistas dos Receptores de Endotelina , Etnicidade , Hipertensão Pulmonar/tratamento farmacológico , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Bosentana , Criança , Método Duplo-Cego , Teste de Esforço , Hipertensão Pulmonar Primária Familiar , Feminino , Seguimentos , Humanos , Hipertensão Pulmonar/etnologia , Hipertensão Pulmonar/fisiopatologia , Isoxazóis/uso terapêutico , Masculino , Pessoa de Meia-Idade , Fenilpropionatos/uso terapêutico , Prevalência , Estudos Prospectivos , Pressão Propulsora Pulmonar/efeitos dos fármacos , Piridazinas/uso terapêutico , Fatores Sexuais , Sulfonamidas/uso terapêutico , Tiofenos/uso terapêutico , Resultado do Tratamento , Estados Unidos/epidemiologia , Caminhada/fisiologia , Adulto Jovem
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