RESUMO
Introducción. En diciembre de 2019 en Wuhan, China, se presentó un brote de neumonía atípica generado por el virus SARS-CoV-2, el cual es un tipo de coronavirus causante de la enfermedad COVID-19, que se convirtió con el tiempo en una pandemia. En este contexto, el uso de los elementos de protección personal tomó un especial interés, en especial para la atención del trabajo de parto vaginal, dada la confusión en los círculos obstétricos respecto a la mejor forma de proteger al personal sanitario en dichos casos. El objetivo de este artículo de revisión es identificar cuáles son los elementos de protección personal indicados en la atención del parto vaginal y su correcto uso en tiempos de COVID-19. División de temas tratados. Se realizó una revisión narrativa de la literatura accediendo a las bases de datos: PubMed, Medline, Elsevier, Google Académico y sitios web como la Organización Mundial de la salud (OMS), Centros para el Control y la Prevención de Enfermedades (CDC, por sus siglas en inglés) y el Colegio Americano de Obstetras y Ginecólogos (ACOG), entre otros. Se usaron palabras claves como "Infecciones por Coronavirus", "Parto Normal", "Protección Personal", "Personal de Salud", "Dispositivos de Protección Respiratoria" y "Dispositivos de Protección de los Ojos". La literatura permitió identificar aspectos introductorios al tema, epidemiología, características generales de los elementos de protección personal, y los elementos específicos para el uso correcto en la atención del parto vaginal. Conclusiones. El trabajo de parto es considerado como un procedimiento generador de aerosoles, por lo que se recomienda principalmente el uso de tapabocas N95 o un respirador que ofrezca mayor protección para personal de salud en la atención del parto vaginal, con el fin de evitar la infección por SARS-CoV-2; sin embargo, se debe insistir en el uso adecuado y completo de los elementos de protección personal como lo son la bata quirúrgica, el gorro, el protector ocular y guantes, independientemente de la sintomatología de la paciente.
Introduction. In December 2019, in Wuhan, China, there was an outbreak of atypical pneumonia caused by the SARS-CoV-2 virus, which is a type of coronavirus causative of COVID-19, which overtime became a pandemic. In this context, the use of personal protective equipment is of special interest, especially when providing care in vaginal delivery, due to the confusion in obstetric circles regarding the best way to protect healthcare personnel in these cases. The objective of this review article is to identify which are the personal protective elements indicated for providing care in vaginal birth and their correct use during COVID-19. Division of Covered Topics. A narrative review of the literature was carried out, accessing the following databases: PubMed, Medline, Elsevier, Google Scholar, and websites such as the World Health Organization (WHO), Center for the Control and Prevention of Diseases (CDC), and the American College of Obstetricians and Gynecologists, among others. Keywords such as "Coronavirus Infections", "Normal Birth," Personal Protective Elements," "Healthcare Personnel", "Respiratory Protective Devices", and "Eye Protection Devices" were used. The literature allowed us to identify introductory aspects on the matter, epidemiology, general characteristics of personal protective elements, and the specific elements for correct use when providing care in vaginal birth. Conclusions. Labor is considered an aerosol-generating procedure. Therefore, the main recommendation is the use of an N95 mask or a respirator which allows for greater protection for healthcare personnel when assisting vaginal birth, in order to avoid infection due to SARS-CoV-2. However, there must be an adequate and complete use of personal protective equipment, such as surgical gowns, hats, eye protection and gloves, regardless of the patient's symptomatology
Introdução. Em dezembro de 2019 em Wuhan, na China, houve um surto de pneumonia atípica gerada pelo vírus SARS-CoV-2, que é um tipo de coronavírus que causa a doença COVID-19, que, com o tempo, acabou se tornando uma pandemia. Nesse contexto, o uso de elementos de proteção individual tornou-se de particular interesse, especialmente para a assistência do parto vaginal, dada a confusão nos círculos obstétricos quanto à melhor forma de proteger os profissionais da saúde nesses casos. O objetivo deste artigo de revisão é identificar os elementos de proteção individual indicados na assistência do parto vaginal e seu uso correto em tempos de COVID-19. Divisão de tópicos abordados. Foi realizada uma revisão narrativa da literatura acessando as seguintes bases de dados: PubMed, Medline, Elsevier, Google Scholar e sites como a Organização Mundial da Saúde (OMS), Centros de Controle e Prevenção de Doenças (CDC, na sigla em inglês) e o Colégio Americano de Obstetras e Ginecologistas (ACOG), entre outros. Foram utilizadas palavras-chave como "Infecções por Coronavírus", "Parto Normal", "Proteção Pessoal", "Pessoal de Saúde", "Dispositivos de Proteção Respiratória" e "Dispositivos de Proteção Ocular". A literatura permitiu identificar aspectos introdutórios ao tema, epidemiologia, características gerais dos elementos de proteção individual e elementos específicos para o uso correto na assistência do parto vaginal. Conclusões. O trabalho de parto é considerado um procedimento gerador de aerossóis, portanto, recomenda-se principalmente o uso de máscaras N95 ou um respirador que ofereça maior proteção para os profissionais de saúde na assistência do parto vaginal, a fim de evitar a infecção pelo SARS-CoV-2; no entanto, deve-se insistir no uso adequado e completo de elementos de proteção individual, como bata cirúrgica, touca, protetor ocular e luvas, independentemente dos sintomas do paciente.
Assuntos
Proteção Pessoal , Roupa de Proteção , Dispositivos de Proteção Respiratória , Pessoal de Saúde , Infecções por Coronavirus , Dispositivos de Proteção dos Olhos , Luvas Cirúrgicas , Parto NormalRESUMO
The Caribbean region presents the highest prevalence of HIV/AIDS worldwide after sub-Saharan Africa; leading to serious social, economic and health consequences at the local scale but also at the regional and global levels. In Colombia, a national plan to tackle the epidemic was formulated with little evidence that its implementation in the local context is effective. This study focused on Cartagena - one of Colombia's largest cities and an international touristic hub - that presents one of the highest HIV prevalences in the country, to investigate whether the national plan accounts for local specificities and what are the barriers to local implementation. Based on the Contextual Interaction Theory (CIT), this qualitative research relied upon 27 interviews and 13 life stories of local inhabitants and stakeholders, collected in a first fieldwork in 2006-2007. A follow-up data collection took place in 2013 with 10 participants: key policymakers and implementers, NGO representatives and local inhabitants. Barriers identified by the participants included: local population's understandings and beliefs on condom use; stigma and discrimination; lack of collaboration from the Church, the education sector and local politicians; corruption; high staff turnover; frequent changes in leadership; lack of economic and human resources; and barriers to health care access. The findings suggest that global influences also have an impact on the CIT framework (e.g. international organisations as a major financier in HIV prevention). The participants put forward several feasible solutions to implementation barriers. We discuss how several of the proposed solutions have been applied in other Latin American and Caribbean countries and yielded positive results. However, further research is needed to find possible ways of overcoming certain barriers identified by this study such as corruption, the lack of collaboration of the Church and barriers to health care access.
Assuntos
Infecções por HIV/prevenção & controle , Conhecimentos, Atitudes e Prática em Saúde , Política de Saúde , Síndrome da Imunodeficiência Adquirida/prevenção & controle , Catolicismo , Colômbia , Preservativos/estatística & dados numéricos , Feminino , Identidade de Gênero , Acessibilidade aos Serviços de Saúde/organização & administração , Necessidades e Demandas de Serviços de Saúde/organização & administração , Humanos , Masculino , Modelos Teóricos , Religião e Medicina , Comportamento Sexual , Estigma SocialRESUMO
Bovine viral diarrhea virus (BVDV) is considered an important cause of economic loss within bovine herds worldwide. In Argentina, only the use of inactivated vaccines is allowed, however, the efficacy of inactivated BVDV vaccines is variable due to its low immunogenicity. The use of recombinant subunit vaccines has been proposed as an alternative to overcome this difficulty. Different studies on protection against BVDV infection have focused the E2 protein, supporting its putative use in subunit vaccines. Utilization of transgenic plants expressing recombinant antigens for the formulation of experimental vaccines represents an innovative and cost effective alternative to the classical fermentation systems. The aim of this work was to develop transgenic alfalfa plants (Medicago sativa, L.) expressing a truncated version of the structural protein E2 from BVDV fused to a molecule named APCH, that target to antigen presenting cells (APCH-tE2). The concentration of recombinant APCH-tE2 in alfalfa leaves was 1 µg/g at fresh weight and its expression remained stable after vegetative propagation. A methodology based an aqueous two phases system was standardized for concentration and partial purification of APCH-tE2 from alfalfa. Guinea pigs parentally immunized with leaf extracts developed high titers of neutralizing antibodies. In bovine, the APCH-tE2 subunit vaccine was able to induce BVDV-specific neutralizing antibodies. After challenge, bovines inoculated with 3 µg of APCH-tE2 produced in alfalfa transgenic plants showed complete virological protection.
Assuntos
Doença das Mucosas por Vírus da Diarreia Viral Bovina/prevenção & controle , Vírus da Diarreia Viral Bovina Tipo 1/imunologia , Medicago sativa/genética , Medicago sativa/imunologia , Vacinas Virais/farmacologia , Animais , Anticorpos Neutralizantes/biossíntese , Anticorpos Antivirais/biossíntese , Doença das Mucosas por Vírus da Diarreia Viral Bovina/imunologia , Doença das Mucosas por Vírus da Diarreia Viral Bovina/virologia , Bovinos , Vírus da Diarreia Viral Bovina Tipo 1/genética , Feminino , Cobaias , Masculino , Plantas Geneticamente Modificadas , Proteínas Recombinantes de Fusão/genética , Proteínas Recombinantes de Fusão/imunologia , Resultado do Tratamento , Vacinação/veterinária , Vacinas Sintéticas/genética , Vacinas Sintéticas/imunologia , Vacinas Sintéticas/farmacologia , Proteínas do Envelope Viral/genética , Proteínas do Envelope Viral/imunologia , Vacinas Virais/genética , Vacinas Virais/imunologiaRESUMO
This paper reports on an ethnographic study in Cartagena, Colombia. Over a seven-month fieldwork period, 35 men and 35 women between 15 and 60 years of age discussed the social context of HIV/AIDS through in-depth interviews, life histories and drawing. Participants considered the transgression of traditional gender roles as prescribed by machismo a major risk factor for HIV infection. In addition, they integrated public-health concepts of risk groups with these long-standing constructions of gender roles and sexuality-related stigma to create the notion of 'AIDS carriers'. The bricolage between machismo, public health and sexuality-related stigma that participants created and consequent preventive measures (based on an avoidance of sex with people identified as 'AIDS carriers') was a dynamic process in which participants were aware that changes in this particular interpretation of risk were necessary to confront the local epidemic.
Assuntos
Características Culturais , Infecções por HIV/psicologia , Saúde Pública , Estigma Social , Estereotipagem , Adolescente , Adulto , Colômbia , Feminino , Humanos , Entrevistas como Assunto , Masculino , Pessoa de Meia-Idade , Fatores de RiscoRESUMO
OBJECTIVE: To obtain a thorough understanding of the complexity and dynamics of the social determination of HIV infection among inhabitants of Cartagena, Colombia, as well as their views on necessary actions and priorities. METHODS: In a five-year ethnography of HIV/AIDS in collaboration with 96 citizens of Cartagena, different methods and data collection techniques were used. Through 40 in-depth interviews and 30 life histories of inhabitants, the scenario of HIV vulnerability was summarized in a diagram. This diagram was evaluated and complemented through group discussions with key representatives of local governmental and nongovernmental organizations and with people who were interested in the epidemic or affected by it. RESULTS: The diagram illustrates the dynamic and complex interrelationships among structural factors (i.e., social determinants) of HIV infection, such as machismo; lack of work, money, and social services; local dynamics of the performance of the state; and international dynamics of the sexual tourism industry. On the basis of the diagram, groups of key representatives proposed prioritizing structural actions such as reducing socioeconomic inequalities and providing access to health care and education. CONCLUSIONS: The social determinants displayed in the diagram relate to historic power forces that have shaped vulnerable scenarios in Cartagena. Collaboration between participants and researchers generates conceptual frameworks that make it possible to understand and manage the complexity of HIV's social determination. This way of understanding effectively connects local inequalities with international flows of power such as sexual tourism and makes evident the strengths and limitations of current approaches to HIV prevention.
Assuntos
Infecções por HIV/prevenção & controle , Meio Social , Saúde da População Urbana , Adulto , Antropologia Cultural , Atitude Frente a Saúde , Colômbia/epidemiologia , Feminino , Infecções por HIV/epidemiologia , Infecções por HIV/psicologia , Infecções por HIV/transmissão , Conhecimentos, Atitudes e Prática em Saúde , Prioridades em Saúde , Acessibilidade aos Serviços de Saúde , Necessidades e Demandas de Serviços de Saúde , Humanos , Liderança , Masculino , Pacientes/psicologia , Pobreza , Pesquisa Qualitativa , Fatores de Risco , Estudos de Amostragem , Profissionais do Sexo , Comportamento Sexual , Fatores Socioeconômicos , Populações VulneráveisRESUMO
OBJECTIVE: To obtain a thorough understanding of the complexity and dynamics of the social determination of HIV infection among inhabitants of Cartagena, Colombia, as well as their views on necessary actions and priorities. METHODS: In a five-year ethnography of HIV/AIDS in collaboration with 96 citizens of Cartagena, different methods and data collection techniques were used. Through 40 in-depth interviews and 30 life histories of inhabitants, the scenario of HIV vulnerability was summarized in a diagram. This diagram was evaluated and complemented through group discussions with key representatives of local governmental and nongovernmental organizations and with people who were interested in the epidemic or affected by it. RESULTS: The diagram illustrates the dynamic and complex interrelationships among structural factors (i.e., social determinants) of HIV infection, such as machismo; lack of work, money, and social services; local dynamics of the performance of the state; and international dynamics of the sexual tourism industry. On the basis of the diagram, groups of key representatives proposed prioritizing structural actions such as reducing socioeconomic inequalities and providing access to health care and education. CONCLUSIONS: The social determinants displayed in the diagram relate to historic power forces that have shaped vulnerable scenarios in Cartagena. Collaboration between participants and researchers generates conceptual frameworks that make it possible to understand and manage the complexity of HIV's social determination. This way of understanding effectively connects local inequalities with international flows of power such as sexual tourism and makes evident the strengths and limitations of current approaches to HIV prevention.
OBJETIVO: Explorar la comprensión de los habitantes sobre la determinación social de la infección por el VIH en Cartagena, Colombia, y sus criterios sobre las medidas necesarias y las prioridades. MÉTODOS: Se usaron diferentes métodos y técnicas de recolección de datos en una investigación etnográfica quinquenal de la infección por el VIH/sida en colaboración con 96 ciudadanos de Cartagena. Se resumió en un diagrama la situación de vulnerabilidad al VIH tras analizar la información obtenida en 40 entrevistas a profundidad y 30 historias de vida de los habitantes. Este diagrama se evaluó y se complementó por medio de análisis grupales con representantes clave de organizaciones gubernamentales y no gubernamentales locales y con personas interesadas en la epidemia o afectadas por ella. RESULTADOS: El diagrama ilustra las interrelaciones dinámicas y complejas que existen entre los factores estructurales (es decir, determinantes sociales) de la infección por el VIH, como el machismo; la falta de trabajo, dinero y servicios sociales; la dinámica local de la función del estado; y la dinámica internacional de la industria del turismo sexual. Sobre la base del diagrama, los grupos de representantes clave propusieron medidas estructurales prioritarias, como reducir las desigualdades socioeconómicas y proporcionar acceso a la atención de salud y la educación. CONCLUSIONES: Los determinantes sociales que se muestran en el diagrama se relacionan con las fuerzas de poder que históricamente han configurado situaciones de vulnerabilidad en Cartagena. La colaboración entre los participantes y los investigadores genera marcos conceptuales que permiten comprender y gestionar la complejidad de la determinación social de la infección por el VIH. Este enfoque permite relacionar las desigualdades locales con los flujos internacionales de poder, como el turismo sexual, y pone de manifiesto las ventajas y las limitaciones de los métodos actuales para la prevención de la infección por el VIH.