RESUMO
OBJECTIVE: estimate colorectal cancer incidence and prevalence in, based on mortality and survival data from the period 1998-2007, and provide projections of incidence, prevalence and mortality until the year 2022. METHODS: general and colorectal cancer mortality rates were obtained from the National Statistics Institute and survival data was obtained from the EUROCARE study. Estimations were carried out through the program MIAMOD. The joinpoint program was used to quantify the annual change expected in the projections. RESULTS: in men, an increase in prevalence is expected, from 237.2 (Crude Rate - CR = 303.5) to 237.7 (CR = 412.7) per 100.000 inhabitants/year in 2022. Incidence rates would increase from 48.2 (CR = 61.6) in 2007 to 55.2 (CR = 83.1), and mortality would increase from 22.7 (CR = 29.4) to 26.0 (CR = 39.6) when comparing 2007 and women, a reduction in prevalence is expected from 181.5 (CR = 268.3) to 167.9 (CR = 286.2) cases per 100,000 inhabitants/year. Incidence would change from 25.0 (CR = 38.0) in 2007 to 22.7 (CR = 39.2), and for mortality there is also an expected decrease, from 11.3 (CR =18.0) to 10.3 (CR = 18.5). CONCLUSION: the projections indicate that colorectal cancer in follows an increasing trend in incidence, mortality and prevalencein men, in opposition to corresponding decreasing trends in women.These projections must be considered in order to plan more effective prevention and treatment measures.
Assuntos
Neoplasias Colorretais/epidemiologia , Neoplasias Colorretais/mortalidade , Adulto , Idoso , Idoso de 80 Anos ou mais , Bases de Dados Factuais , Feminino , Previsões , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Fatores Sexuais , Espanha/epidemiologia , Análise de SobrevidaRESUMO
Golden hamsters were infected orally with viable cysticerci of Taenia solium obtained from infected pigs. After two weeks of infection implanted scolices of about 4 mm were found in exactly the same number as the number of ingested cysticerci. At six weeks 66% of the ingested cysticerci were found as implanted tapeworms (average size: 5.7 cm). At ten weeks 16% of the ingested cysticerci were found as implanted tapeworms (average size: 5.8 cm). At 14 weeks no tapeworms were found. Skin tests with taenia extracts were positive after 9 weeks of infection peaked at 12 and 14 weeks and declined afterwards becoming negative after 27 weeks. Skin test with cysticercus extracts were weaker, peaked at 8 and 10 weeks, were very low after 12 weeks and became negative after 16 weeks. Histological studies in the attachment site at the small intestine showed at 2 weeks a cellular infiltrate formed by macrophages, epithelioid cells and some plasma cells, there was very little alteration of epithelium. At 6 and 8 weeks the epithelium was damaged and necrotized. At 17 and 19 weeks the lesion started to resolve. We conclude that the golden hamster can be used to reproduce in the laboratory at least part of the life cycle of Taenia solium.
Assuntos
Cisticercose/parasitologia , Cysticercus/isolamento & purificação , Mesocricetus/parasitologia , Animais , Anticorpos Anti-Helmínticos/sangue , Cricetinae , Cisticercose/sangue , Cysticercus/imunologia , Eosinofilia/parasitologia , Feminino , Inflamação/parasitologia , Masculino , Mesocricetus/sangueRESUMO
Se realizaron estudios sobre la susceptibilidad de cepas de virus aftoso en Colombia a la accion de la temperatura (26o C y 37o C) y de agentes inactivantes acetiletilenimina (AEI) y etileniminabinaria.(BEI) aplicando procesos corrientes de in activacion o mediante la tecnica de estabilidad termica a 47.5oC durante 5 minutos. Las observaciones sobre la concentracion de particulas 146S de cada virus fueron efectuadas aplicando analisis lineares de gradientes de densidad de sucrosa. En nuestros resultados se obtuvo una mayor susceptilizada a la degradacion del virus Tipo O Subtipo 1 (Cepa 9489) respecto a la observada con el virus O1 (Cepa Campos).Las Cepas de Tipo A Subtipo 24 (Cruzeiro)y A27 (8046) fueron mas resistentes a la accion de la temperatura y de los inactivantes utilizados en estos ensayos que los virus O1