1.
Nucleosides Nucleotides Nucleic Acids
; 23(5): 735-48, 2004 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15281362
RESUMO
Several new pyrazolo[4,3-c]quinolin-3-one ribonucleosides (5a-g) and their corresponding heterocycle moieties (3a-g) were synthesized and evaluated against vaccinia virus (VV) and herpes simplex virus type 1 (HSV-1). The derivatives 3c and 3d showed modest inhibitory activity against vaccinia virus reaching 70% at a concentration of 100 microM. All heterocyclic compounds (3a-f) showed a modest inhibition against HSV-1, reaching the maximal inhibitory effect around 20-30%. The antiviral effects of most of the pyrazolo[4,3-c]quinolin-3-one ribonucleosides (5a-f) on VV and HSV were not impressive.
Assuntos
Antivirais/síntese química , Antivirais/farmacologia , Pirazóis/farmacologia , Quinolinas/farmacologia , Ribonucleosídeos/síntese química , Ribonucleosídeos/farmacologia , Animais , Linhagem Celular , Herpesvirus Humano 1/efeitos dos fármacos , Humanos , Pirazóis/química , Quinolinas/química , Vaccinia virus/efeitos dos fármacos , Replicação Viral/efeitos dos fármacos
2.
Mem. Inst. Oswaldo Cruz
; 86(3): 365-6, jul.-set. 1991. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-109178