RESUMO

Proteins are the structural, functional and evolutionary units of cells. On their surface, proteins are shaped into numerous depressions and protrusions that provide unique microenvironments for ligand binding and catalysis. The dynamics, size and chemical properties of these cavities are essential for a mechanistic understanding of protein function. Here, we present CaviDB, a novel database of cavities and their features in known protein structures. It integrates the results of commonly used cavity detection software with protein features derived from sequence, structural and functional analyses. Each protein in CaviDB is linked to its corresponding conformers, which also facilitates the study of conformational changes in cavities. Our initial release includes ∼927 773 distinct proteins, as well as the characterization of 36 136 869 cavities, of which 1 147 034 were predicted to be drug targets. The structural focus of CaviDB provides the ability to compare cavities and their properties from different conformational states of the protein. CaviDB not only aims to provide a comprehensive database that can be used for various aspects of drug design and discovery but also contributes to a better understanding of the fundamentals of protein structure-function relationships. With its unique approach, CaviDB represents an indispensable resource for the large community of bioinformaticians in particular and biologists in general. Database URL https://www.cavidb.org.

Assuntos

RESUMO

There are multiple tools for positive selection analysis, including vaccine design and detection of variants of circulating drug-resistant pathogens in population selection. However, applying these tools to analyze a large number of protein families or as part of a comprehensive phylogenomics pipeline could be challenging. Since many standard bioinformatics tools are only available as executables, integrating them into complex Bioinformatics pipelines may not be possible. We have developed OBI, an open-source tool aimed to facilitate positive selection analysis on a large scale. It can be used as a stand-alone command-line app that can be easily installed and used as a Conda package. Some advantages of using OBI are:•It speeds up the analysis by automating the entire process•It allows multiple starting points and customization for the analysis•It allows the retrieval and linkage of structural and evolutive data for a protein throughWe hope to provide with OBI a solution for reliably speeding up large-scale protein evolutionary and structural analysis.

RESUMO

BACKGROUND AND OBJECTIVES: Treg and TH17 cells influence the inflammatory process in periodontal diseases and could also play in a similar pattern, an essential role in immune-inflammatory mechanisms involved in the destruction of the peri-implant tissues, peri-implantitis. Therefore, this study evaluated the levels of RORγT and FOXP3 gene expression in subjects with peri-implantitis and healthy peri-implant tissues. METHODS: A total of 35 subjects with implant-supported restorations in both diseased and healthy clinical conditions (n = 15 healthy; n = 20 peri-implantitis) were included in this study. Peri-implantitis was defined as probing depth > 5 mm, bleeding on probing and/or suppuration, and peri-implant bone loss >4 mm. Peri-implant tissue biopsies were collected for analysis of the mRNA, RORγT, and FOXP3 expression levels. The samples were submitted to total RNA extraction, treatment with DNAse, and cDNA synthesis. Subsequently, real-time PCR reaction was performed to evaluate the levels of RORγT and FOXP3 gene expression to the reference gene. These were analyzed by the non-parametric Mann-Whitney method with a level of significance of 5%. RESULTS: Higher gene expression levels of the transcription factors RORγT and FOXP3 were detected in the tissues affected by peri-implantitis when compared with healthy tissues (p < 0.05). CONCLUSIONS: The present study demonstrated the possible existence of a hybrid TH17-Treg profile, based on the gene expression of transcription factors inducing differentiation of these cells. Further studies must be designed to gain a better understanding of the immunological mechanisms involved in the pathogenesis of peri-implantitis. CLINICAL RELEVANCE: The levels of RORγT and FOXP3 transcription factors that were linked to cells with the FOXP3+RORγT+ phenotype could be used as a predictor of peri-implantitis progression.

Assuntos

RESUMO

BACKGROUND: This study evaluated the impact of strontium ranelate on tooth-extraction wound healing in estrogen-deficient and estrogen-sufficient rats. METHODS: Ninety-six Wistar rats (90 days of age) were allocated into one of the following groups: sham-surgery+water (estrogen-sufficient); ovariectomy+water (estrogen-deficient), sham-surgery+strontium ranelate (625 mg/kg/d) (strontium/estrogen-sufficient); ovariectomy+strontium ranelate (625 mg/kg/d) (strontium/estrogen-deficient). Water or strontium ranelate were administrated from the 14th day post-ovariectomy/sham surgery until euthanasia. Maxillary first molars were extracted at 21 days after sham/ovariectomy surgery. Rats were euthanized at 10, 20, and 30 days post-extractions. The following parameters were analyzed inside tooth-extraction wound: proportion of newly formed bone (bone healing/BH), number of cells stained for tartrate-resistant acid phosphatase (TRAP) and immunohistochemical staining for five bone metabolism-related markers (osteocalcin [OCN], osteopontin [OPN], bone sialoprotein [BSP], osteoprotegerin [OPG] and receptor activator of NF-КB ligand [RANKL]). RESULTS: The estrogen-deficient group presented lower BH than all other groups at 20 and 30 days post-extraction (P < 0.05). The number of TRAP-stained cells was higher in the estrogen-deficient group than in estrogen-sufficient group at 30 days post-extraction (P < 0.05). The strontium /estrogen-sufficient group exhibited stronger staining for OCN, when compared to the estrogen-sufficient and estrogen-deficient groups (P < 0.05). Both strontium ranelate-treated groups presented higher staining of OPN and BSP than both untreated groups (P < 0.05). The strontium/estrogen-sufficient group demonstrated stronger staining for OPG than the estrogen-deficient group (P < 0.05). The estrogen-sufficient group and both groups treated with strontium ranelate showed lower expression of RANKL than the estrogen-deficient group (P < 0.05). CONCLUSIONS: Strontium ranelate benefited BH and the expression of bone markers in tooth-extraction wound in estrogen-deficient rats whereas its benefits in estrogen-sufficient rats were modest.

Assuntos

RESUMO

A tela de titânio é um recurso importante e amplamente utilizado em diversos tipos de enxertos ósseos. Contudo, apresenta um alto índice de exposição, o que pode comprometer total ou parcialmente o tratamento. Nesse contexto, é importante o profissional compreender diferentes formas de lidar com essa intercorrência, possibilitando o melhor prognóstico possível do enxerto, além de diminuir o desconforto do paciente. O presente trabalho apresenta um caso clínico de enxerto particulado com tela de titânio na região anterior da maxila, com exposição precoce e persistente do enxerto, mesmo frente a diferentes intervenções. O relato descreve as abordagens envolvidas em diferentes momentos da exposição e discute os aspectos teóricos e práticos envolvidos, incluindo a etiologia, os biomateriais utilizados, sua relação com exposições ao meio bucal e as prováveis razões pela quais o enxerto não apresentou perda significante de volume, mesmo após 41 dias exposto ao meio bucal.

Titanium mesh is an important and widely used resource in several types of bone grafts. However, it has a high prevalence of exposure, which may partially or totally compromise the treatment. In this sense, it is important for the professional to understand different ways of dealing with this problem, allowing the best possible prognosis of the graft, besides reducing the discomfort of the patient. The present work presents a case report of particulate graft with titanium mesh in the anterior region of the maxilla, with early and persistent graft exposure, even in front of different interventions. This report describes the approaches involved in different times of exposition and discusses the theoretical and practical aspects involved, including etiology, the biomaterials used, its relation with exposures to the oral environment and the likely reasons why the graft did not present signifi cant loss of volume, even after 41 days exposed to the mouth.

Assuntos

RESUMO

O PRF líquido pode facilitar o posicionamento e a escultura de enxertos ósseos particulados, além dos possíveis benefícios relacionados ao reparo ósseo e fibromucosa. Para tanto, é necessário que o profissional conheça os aspectos práticos e teóricos envolvidos no seu uso. Um paciente com 45 anos de idade, apresentava perda dos incisivos maxilares e de espessura da crista óssea na região, impossibilitando a colocação de implantes de diâmetro convencional. Para a regeneração óssea, foi utilizado enxerto com substituto ósseo associado a coágulos de PRF, PRF líquido e tela de titânio. Após o reparo ósseo, foram instalados dois implantes na região dos incisivos laterais como pilares de uma prótese parcial fixa de quatro elementos. O PRF líquido pode facilitar procedimentos de enxertia óssea e diminuir o risco de iatrogenia sem, contudo, aumentar significativamente o custo e o tempo do tratamento.

The liquid PRF can facilitate the positioning and carving of particulate bone grafts, in addition to possible benefi ts related to bone and soft tissue repair. Therefore, it is necessary that the professional knows the practical and theoretical aspects involved in its use. A 45-year-old patient presented loss of maxillary incisors and thickness of the bone crest in the region, making it impossible to place implants of conventional diameter. For bone regeneration, graft was used with bone substitute associated with PRF clots, liquid PRF and titanium mesh. After bone repair, two implants were installed in the region of the lateral incisors as pillars of a fixed partial denture of four elements. The liquid PRF can facilitate bone graft procedures and reduce the risk of iatrogenic, without, however, significantly increasing the cost and time of treatment.

Assuntos

RESUMO

Objetivo: apresentar, através de um caso clínico, a utilização de coroas de dentes extraídos como provisórios em próteses fixas unitárias maxilares anteriores, favorecendo aspectos como estética, conforto psicológico, perfil de emergência, biocompatibilidade com tecidos moles e durabilidade em relação a provisórios fixos convencionais. Características do paciente: alta demanda estética, apresentando incisivos centrais maxilares com indicação de substituição por implantes, mas com estética coronária satisfatória. Tratamento propriamente dito: através de desgaste seletivo da coroa original, cobertura do intermediário metálico com resina opaca e preenchimento com resina flow, foi possível a utilização das coroas originais da paciente como provisórios imediatos. Conclusão: a utilização de coroas fixas implantossuportadas construídas a partir de coroas naturais pode melhorar aspectos estéticos, biológicos e psicológicos do tratamento, quando corretamente indicadas e aplicadas.

Objective: to present a case report of the use of extracted teeth as provisional crowns in fixed maxillary prosthesis, favoring aesthetics, psychological comfort, emergency profile, soft tissue biocompatibility and durability in relation to conventional fixed prosthesis. Patient characteristics: patient with high aesthetic demand, presenting maxillary central incisors with indication for replacement with implants, but with satisfactory dental aesthetics. Proposed treatment: through selective wear of the original crown, coating of the metallic abutment with opaque resin and filling with flow resin, it was possible the use of the patient's original crowns as immediate prosthesis. Conclusion: the option to use implantsupported fi xed crowns constructed from natural crowns can help patients with aesthetic, biological and psychological aspects of the treatment, as long as correctly indicated and applied.

Assuntos

RESUMO

The aim of this study was to describe periodontal effects and treatment time of Periodontally Accelerated Osteogenic Orthodontics (PAOO) and to determine if Deoxypyridinoline could be used as a biochemical marker of bone turnover in patients undergoing PAOO. We compared 5 patients undergoing PAOO (5 males, mean age: 29.6±9.8 years) with 5 control patients undergoing self-ligating orthodontics (5 males, mean age: 28.5±6.3 years). All patients were evaluated using panoramic and lateral x-rays and CBCT and randomly selected in experimental and control groups. Both groups underwent self-ligating orthodontics using Damon Q braces. Only the experimental group underwent PAOO. The patients were evaluated periodontally at T1 (before surgery and orthodontic movement) and T2 (after orthodontic treatment). The total treatment time for the experimental group was 8.2±3.3 months and for the control group was 13.4±7.3 months. There were no differences between T2-T1 periodontal variables in either of the groups. Gingival recession was 0.49±0.26 mm at T1 and 0.42±0.3 mm at T2 in the experimental group. Gingival recession was 0.55±0.31 mm at T1 and 1.19±0.24 mm at T2 in the control group. Deoxypyridinoline urine levels showed great variance between individuals and between groups. There is a reduction in treatment time for patients undergoing PAOO with DAMON Q braces. There is no difference in the periodontal condition between PAOO and conventional orthodontics.

El objetivo de este estudio fue describir los efectos periodontales y el tiempo de tratamiento de ortodoncia osteogénica periodontalmente acelerada (OOPA) y para determinar si desoxipiridinolina podría ser utilizado como un marcador bioquímico de recambio óseo en pacientes sometidos a OOPA. Se estudiaron 5 pacientes sometidos a OOPA (hombres, edad media de 29,6±9,8 años) y 5 pacientes control sometidos a ortodoncia de autoligado (hombres, edad media de 28,5±6,3 años). Todos los pacientes fueron evaluados utilizando radiografías panorámicas y laterales, tomografía computadorizada de haz cónico, y luego distribuidos aleatoriamente en grupos experimentales y de control. Ambos grupos fueron sometidos a la ortodoncia de autoligado utilizando dispositivos ortodónticos Damon Q. Sólo el grupo experimental fue sometido a OOPA. Los pacientes fueron evaluados periodontalmente en T1 (antes de la cirugía y el movimiento de ortodoncia) y T2 (después de un tratamiento de ortodoncia). El tiempo total de tratamiento para el grupo experimental fue de 8,2±3,3 meses y para el grupo control 13,4±7,3 meses. No hubo diferencias entre las variables periodontales T2-T1 en cualquiera de los grupos. La recesión gingival en el grupo experimental fue de 0,49±0,26 mm en T1 y 0,42±0,3 mm en T2. En el grupo control, la recesión gingival fue 0,55±0,31 mm en T1 y 1,19±0,24 mm en T2. Los niveles de desoxipiridinolina en orina mostraron gran variación entre individuos y entre grupos. Hubo una reducción en el tiempo de tratamiento para los pacientes sometidos OOPA con dispositivos ortodónticos Damon Q. No hubo diferencia en la condición periodontal entre pacientes sometidos a OOPA y ortodoncia convencional.

Assuntos

RESUMO

O presente trabalho relatou um tratamento com enxerto ósseo, mas sem osso autógeno, de uma maxila atrófica com necessidade de aumento vertical. Foi utilizada uma combinação de rhBMP-2 (Infuse Bone Graft, Medtronic, Minneapolis, EUA), osso bovino particulado (Lumina Bone ­ Large Grain, Criteria, São Carlos, Brasil), tela de titânio (Ti Mesh-Lock, Intra-Lock, São Paulo, Brasil), fibrina rica em plaquetas leucócitos (L-PRF ­ Intra-Lock, São Paulo, Brasil) e incisão de acesso a distância. Após seis meses, as placas de titânio foram removidas e seis implantes foram instalados para suporte de uma prótese total fixa, confeccionada seis meses após a colocação dos implantes. O controle de um ano após instalação da prótese revelou estabilidade do enxerto e dos implantes, sem condições de anormalidade.

This paper describes a treatment with bone graft, but without autogenous bone, in an atrophic maxilla in need of vertical augmentation. A combination of rhBMP-2 (Infuse Bone Graft, Medtronic, Minneapolis, USA), particulate bovine bone (Lumina Bone ­ Large Grain, Criteria, São Carlos, Brazil), titanium mesh (Ti Mesh-Lock, Intra-Lock, São Paulo, Brazil), leukocyte and platelet-rich fibrin (L-PRF ­ Intra-Lock, São Paulo, Brazil) and access with a remote flap incision were used. A discussion on material selection, its advantages, limitations, costs, and treatment time is also presented.

Assuntos

RESUMO

Objetivo: analisar comparativamente o risco de perda óssea peri-implantar em próteses totais fixas na maxila, suportadas por seis implantes paralelos, utilizando conexões do tipo hexágono externo (HE), hexágono interno (HI) e cone-morse (CM) através do método dos elementos finitos 3D. Material e métodos: modelos geométricos de uma maxila e prótese foram construídos e unidos aos modelos de implantes de geometria externa semelhante para representar próteses totais maxilares parafusadas, suportadas por seis implantes paralelos cada uma. Os modelos foram submetidos a cargas mastigatórias axiais e oblíquas. Resultados: o risco de perda óssea na carga oblíqua é muito superior à carga axial; nessa condição, a conexão CM apresentou o menor risco de perda óssea e as conexões HE e HI apresentaram risco semelhante, com risco ligeiramente maior do HI. Conclusão: implantes com conexão CM apresentam menor risco de perda óssea peri-implantar, e implantes com conexão HE e HI apresentam risco similar em próteses totais fixas com implantes paralelos.

Objective: to analyze the risk of peri-implant bone loss in complete fixed, implant-supported prosthesis over six parallel implants using the external hex (EH), internal hex (IH), and morse cone (CM) connections through a 3D finite element method. Material and methods: geometric models of a maxilla and prosthesis were constructed and attached to implant models with similar external geometry to represent maxillary screw-retained dentures supported by six parallel implants each. The models were submitted to axial and oblique masticatory loads. Results: the risk of bone loss under oblique loading is higher than for axial loading; in this condition, the CM connections demonstrated the lowest risk of bone loss, with EH and IH connections showing similar risks, although slightly higher for IH. Conclusion: CM implants present less risk for peri-implant bone loss, and the EH and IH had similar values for complete fixed implant-supported restorations over parallel dental implants.

Assuntos

RESUMO

The lateralization of the inferior alveolar nerve (LIAN) and short implants are efficient options for rehabilitation of the posterior atrophic mandible. However, the loss of bone leads to prosthesis with greater height and lever effect that in turn can have different impact on treatments. Through the finite element method, the present study tests the hypothesis that conventional implants placed under LIAN and short implants have similar risk of bone loss regarding variable height of the crown and that crown-to-implant ratio is not a reliable resource to evaluate risk in these treatments. Computed tomography scans of mandibles were processed and implants and prosthetic components were reverse engineered for reconstruction of three-dimensional models to simulate 3 elements fixed partial dentures supported by 2 osseointegrated implants. The models of implants were based on MK III implants (Nobel Biocare, Zurich, Switzerland) with 4 mm in diameter by 7 mm in length representing short implants, and 15 mm in length representing implants used in LIAN. The implant/crown ratio for short implants was 1:1.5, 1:2, and 1:2.5 and LIAN models were modeled with exactly the same prosthesis, resulting in implant/crown ratios of 1:0.67, 1:0.89, and 1:1.12. The results partially rejected the hypothesis that LIAN and short implants have similar risk of bone loss, showing that although LIAN results were better in the models evaluated, the variations in height had proportionally similar impact on both treatments and accepted the hypothesis that crown-to-implant ratio was not a reliable resource to evaluate risk.

Assuntos

RESUMO

Um dos recursos recentes da engenharia tecidual para auxiliar no tratamento de defeitos ósseos é a proteína morfogenética óssea recombinante BMP-2 (rhBMP-2) que, entre outros fatores, permite melhorar a previsibilidade de volume e contorno de um procedimento de enxertia óssea. Para que seus resultados sejam satisfatórios, é necessário conhecer suas características, vantagens e limitações. O presente trabalho apresentou um caso clínico de grande demanda estética, no qual foi utilizada combinação de rhBMP-2 com osso desproteinizado e tela de titânico para garantir um contorno ósseo adequado na região da maxila anterior. As indicações, características, vantagens e desvantagens do rhBMP-2 como auxiliar em tratamentos de regeneração óssea também foram apresentadas e discutidas...

A recent resource for tissue engineering to assist in the treatment of bone defects is recombinant human bone morphogenetic protein BMP-2 (rhBMP-2), which, among other effects, improves the predictability of the volume and contour of bone grafting procedures. For a satisfactory outcome, it is important to know its characteristics, advantages and limitations. This paper presents a case of great aesthetic demand where the rhBMP-2 was used in combination with deproteinized bone and titanium mesh to ensure adequate bone contour in the anterior maxillary region. The indications, characteristics, advantages and disadvantages of rhBMP-2 as an aid in bone regeneration treatments are also presented and discussed...

Assuntos

RESUMO

A utilização de membranas em procedimentos de ROG é um procedimento comum e representa um recurso oportuno para promover adequado volume ósseo. Contudo, na maioria das vezes, elas são limitadas quanto à exposição ao meio bucal. Para casos em que exista a necessidade de exposição, as membranas densas de politetrafl uoretileno (d-PTFE) estão indicadas. Este trabalho relata a experiência dos autores com 70 casos de ROG para colocação de implantes, utilizando membranas de d-PTFE (Lumina PTFE) com exposição ao meio bucal, e apresenta um caso clínico como exemplo do protocolo cirúrgico utilizado. As membranas foram utilizadas na maxila (n=22/31%), mandíbula (n=15/21%) e ambas as arcadas (n=33/47%), sendo empregados os biomateriais Bio-Oss (n=25/35%), Osteogen (n=14/20%), Lumina Bone (n=8/11%) ou nenhum biomaterial (n=23/33%). Extrações dentárias representam a maioria dos casos (n=57/81%), e todos os pacientes que receberam implantes imediatos (n=31/44%) também receberam simultaneamente algum biomaterial. Nenhum dos casos apresentou complicações cirúrgicas ou foi necessário procedimento adicional para ganho de volume ósseo. Uma discussão sobre as características, vantagens e desvantagens das membranas d-PTFE em relação a outras membranas para ROG também é apresentada.

The use of membranes for GBR procedures is common and represents an excellent chance to establish adequate bone volume. However, for cases where the barrier needs to be exposed, d-polytetrafluorethylene membranes (d-PTFE) are recommended. This paper reports the authors experience with 70 cases of GBR for implant placement using the Lumina PTFE membrane exposed to the buccal environment and still presenting a clinical case protocol description. The membranes were placed in the maxilla (n=22/31%), mandible (n=15/21%), or both jaws (n=33/47%) with associated biomaterials such as Bio-Oss (n=25/35%), Osteogen (n=14/20%), and Lumina Bone (n=8/11%) or none (n=23/33%). Reasons for implant placement included tooth extraction (n=57/81%) and all patients receiving immediate dental implants (n=31/44%) had a simultaneous biomaterial. No surgical complications were observed or an additional procedure needed for bone volume gain. A discussion regarding the characteristics, advantages, and drawbacks of d-PTFE membranes in relation to other GBR membranes is presented.

Assuntos

RESUMO

Dados atuais mostram que apenas 8% da população mundial têm acesso aos 20% de sangue "seguro" para transfusão, devidamente coletados e testados. Apenas 30% das nações do mundo têm serviço transfusional que atende a seu país de forma integrada. Segundo pesquisa conduzida pelo "Committeon Blood and Blood Products of the American Society of Anesthesiologists", grande quantidade do sangue administrado acontece no ambiente cirúrgico. Anestesiologistas devem ser experts em terapia transfusional e conscientes das implicações e complicações que a tomada de decisão pela transfusão pode trazer.

Current data have shown that only 8% of the world's population has access to 20% of "safe" blood dedicated to transfusion, properly collected and tested. Only 30% of the nations around the world have a transfusion service able to work nation wide. According to a research by the "Committee on Blood and Blood Products of the American Society of Anesthesiologists", a great share of the blood given to patients occurs in the cirurgical environment. Anesthesiologists must be experts in transfusional therapy and totally a ware of implications and complications concerning the decision of a blood transfusion.

RESUMO

Características e hábitos dos pacientes podem comprometer tratamentos de enxertos ósseos, mesmo que a técnica e o material utilizados sejam adequados do ponto de vista biológico e celular. Paciente se apresentou com mobilidade de uma prótese total fixa implantossuportada instalada há 22 anos, suportada por implantes do tipo Garbaccio e justaósseo. O planejamento inicial incluiu remoção dos implantes e regeneração óssea com o conjunto rhBMP-2 mais hidroxiapatita, fosfato tricálcio e telas de titânio como arcabouço, porém, ocorreu comprometimento do enxerto, provavelmente devido ao trauma mecânico, químico e térmico do consumo de charuto, mesmo interrompendo o hábito até o selamento da fibromucosa. Para corrigir o problema, uma nova estratégia foi utilizada para evitar o estiramento da fibromucosa, que consiste na colocação de implantes no mesmo dia do enxerto para fornecer rigidez ao mesmo e utilização de L-PRF. Considerações sobre os materiais utilizados, as causas do insucesso inicial e a mudança do plano de tratamento são apresentadas

Dental treatment with bone grafts can be jeopardized in patients presenting certain habits and characteristics even when material and technique are acceptable from the biological standpoint. In this case report, a patient presented with mobility of his implant-supported fixed prosthesis made 22 years ago over Garbaccio and subperiosteal implants. The treatment planning included implant removal and bone regeneration using rhBMP-2, hydroxyapatite, tricalcium phosphate and titanium meshes as scaffolds; however, in the meantime, graft was compromised due to mechanical, chemical, and thermal trauma under cigar smoking, even with cessation until mucosal sealing. To overcome this problem, a new strategy was used to avoid mucosa stretching, with dental implants placed in the same day and reinforced by grafting with L-PRF. Considerations on failure and changes on treatment planning are presented

Assuntos

RESUMO

As manobras para reabilitação com próteses totais fixas implantossuportadas em carga imediata são desgastantes e podem levar o profissional a acelerar o processos. Existe o risco de penetração do material de moldagem na região submucosa após a transferência da posição dos implantes e sem a evidência visual, o clínico pode não desfazer a sutura, gerando grandes quantidades de material na região. Este trabalho alerta para este risco e discute as consequências através de um caso clínico.

The procedures for rehabilitation with complete, fixed, implant-supported prostheses under immediate loading are demanding and can make the clinician speed up the processs. There is the risk of submucosal penetration of the impression material after implant transferring procedures and with no visual evidence sutures will not be removed with large amounts of the impression material inside the wound. This paper points out to this risk and discuss the consequences through a clinical case report

Assuntos

RESUMO

Enxertos ósseos de grande volume podem apresentar dificuldades quanto ao seu recobrimento cirúrgico, risco de exposição e manutenção do volume. Para minimizar os riscos e melhorar a previsibilidade, os autores idealizaram uma técnica de transplante de periósteo pediculado da calota craniana, para recobrir enxertos ósseos maxilares extensos, e são apresentadas as bases teóricas sobre o procedimento. A técnica é apresentada em formato de caso clínico e consiste na abertura do escalpo do paciente, descolamento e transposição da gálea aponeurótica e periósteo para recobrir enxertos ósseos maxilares. Com 18 casos realizados e acompanhamento de 4-17 anos, a técnica se mostrou previsível e segura para casos de enxertos ósseos maxilares de grande volume.

Considerable bone grafts may present complications regarding its surgical risk of exposure and volume maintenance. To minimize risks and improve its predictability, the authors developed a technique to transplant pediculated periosteum of the skull to cover large maxillary bone grafts and present the theoretical basis of the procedure. The technique is presented in consecutive case reports and consists in opening the patient’s scalp, detachment and transposition of aponeurotic galea and periosteum to cover maxillary bone grafts. With 18 cases performed and 4-17 years of monitoring, the technique is predictable and safe in cases of maxillary bone grafts of large volume

Assuntos

RESUMO

A presença de patologias na região apical de um dente comprometido pode interferir diretamente no tratamento com implantes dentários, através da reincidência de infecção, e indiretamente através do trauma necessário para adequada limpeza do sítio infectado. Esse trauma torna-se mais relevante na região anterior maxilar, suscetível à recessão óssea, e recursos que o minimizem estão indicados. Através de um caso clínico, o presente trabalho apresenta o tratamento de uma lesão extensa na região periapical de um incisivo central maxilar com comprometimento da tábua óssea vestibular na região apical. O tratamento consistiu na extração atraumática do dente e incisão de acesso na região periapical, para facilitar o procedimento de debridamento e minimizar o trauma mecânico na região cervical. Após remoção superficial do osso infectado e curetagem da região, um implante foi imediatamente instalado e a região apical foi preenchida com hidroxiapatita sintética para recuperar o volume perdido. No mesmo dia, uma provisória apoiada nos dentes adjacentes foi instalada e, após cinco meses, o paciente recebeu tratamento protético definitivo. Considerações sobre aspectos teóricos e práticos do procedimento são apresentadas e discutidas, com ênfase na previsibilidade estética do tratamento.

Presence of pathologies in the apical region of a compromised tooth can directly interfere with dental implant treatment through the recurrence of infection and indirectly through the trauma required for proper cleaning of the infected site. This trauma becomes more relevant in the anterior maxillary bone, susceptible to bone recession and procedures that minimize it are indicated. Through case report, this paper presents a technique to access the bottom of the vestibule in cases of periapical infection in order to avoid alveolar access and minimize trauma needed to clean the infected area. Considerations about theoretical and practical aspects of the procedure are presented and discussed.

Assuntos

RESUMO

O trauma mecânico causado por técnicas de extração dentária é associado à perda óssea na região periodontal, sendo considerado importante para a estética e o suporte de implantes dentários. Embora técnicas de enxerto e membranas possam compensar essa perda, existe a desvantagem de maior tempo de tratamento e impedir a colocação de implantes imediatos com carga imediata. Os autores analisaram o mecanismo de ação e demonstraram dois casos clínicos do uso de extratores dentários que utilizam tração vertical e não necessitam de nenhum contato de instrumentos no osso periodontal, com intuito de minimizar o trauma ósseo. Para tanto, uma tomografia computadorizada foi reconstruída digitalmente e um modelo tridimensional criado e simulado através do método de elementos finitos, com condições semelhantes à aplicação do extrator vertical no uso clínico. Os resultados demonstraram que o mecanismo de ação dos extratores verticais é favorável para desenvolver pressões trativas sobre o alvéolo e minimizar as pressões compressivas, minimizando o trauma mecânico durante o procedimento de extração. Os autores concluíram que o extrator vertical tem um mecanismo de ação que minimiza o trauma ósseo durante o procedimento de extração

The mechanical trauma caused by tooth extraction is associated with bone loss in the periodontal region, being considered important for dental implant support and esthetics. Although bone grafts and membranes can compensate this loss, associate drawbacks are longer treatment times no immediate loading. The authors analyzed the mechanism of action and demonstrate two clinical cases with dental extractors using vertical traction that require no periodontal bone contact for its use, with the aim of minimizing bone trauma. Therefore, a CT scan was digitally reconstructed and a three-dimensional model created and simulated by finite element method, with similar conditions to the application of vertical extractor in clinical use. The results showed that the mechanism of action of vertical extractors is favorable for developing tensile pressures and minimize compressive pressures on the alveolar bone, minimizing mechanical trauma during tooth extraction. The authors concluded that the vertical extractor has a mechanism of action that minimizes bone trauma during the extraction procedure

Assuntos

RESUMO

Aspergiloma é uma formação fúngica que ocorre em cavidades do sistema respiratório e pode estar associado a tratamentos odontológicos. Paciente do sexo feminino apresentou sinusite crônica persistente não responsiva a farmacoterapia após fixação de quatro implantes zigomáticos. Após exame de tomografia computadorizada verificou-se possível comunicação bucossinusal mantida por um dos implantes e imagem sugestiva de aspergiloma. O presente artigo demonstra os passos para remoção dos implantes infectados e do aspergiloma. Também é apresentada uma discussão sobre as características dos aspergilomas de seio maxilar e os fatores que predispõe a sua formação em tratamentos odontológicos, especialmente com implantes zigomáticos

Aspergilloma is a fungal mass found in cavities of the respiratory system which can be associated to dental treatment. A female patient presented with persistent chronic sinusitis non-responsive to antibiotic therapy after placement of four zygomatic implants. After CBCT scanning, a buco-sinusal communication was evident at one of the zygoma implants with suggestive diagnosis of Aspergillosis. This article illustrates the clinical steps for implant and aspergilloma removal. Also, a discussion is highlightened on this pathology at the maxillary sinus and predisposing factors along with dental treatment, especially for zygomatic dental implants

Assuntos