RESUMO
BACKGROUND: Antibody (Ab) tests for SARS-CoV-2 virus allows for the estimation of incidence, level of exposure and duration of immunity acquired by a previous infection. In health workers, the hospital setting might convey a greater risk of infection. AIMS: To describe the frequency of immunoglobulin G (IgG) Abs (IgG-Abs) to the SARS-CoV-2 virus among workers at a third-level university hospital in Colombia. METHODS: In this cross-sectional study, we included medical and non-medical personnel with at least one real-time polymerase chain reaction (RT-PCR)/antigen test between March 2020 and March 2021. In April 2021, an IgG-Ab test against SARS-CoV-2 was conducted for all participants and replicated 2 weeks later in a random sample (10%). The frequency of IgG-Abs is presented based on status (positive/negative) and time elapsed since RT-PCR/antigen test (<3 months, 3-6 months, >6 months). RESULTS: We included 1021 workers (80% women, median age 34 years (interquartile range 28-42), 73% medical personnel, 23% with previous positive RT-PCR/antigen). The overall seroprevalence was 35% (95% CI 31.6-37.4, 35% in medical and 33% in non-medical personnel). For those with a previous positive RT-PCR/antigen test, the seroprevalence was 90% (<3 months), 82% (3-6 months) and 48% (>6 months). In participants with a previous negative RT-PCR/antigen test, the seroprevalence was 17% (<3 months), 21% (3-6 months) and 29% (>6 months). CONCLUSIONS: High IgG-Ab positivity was found in hospital personnel, regardless of work activities. The prevalence of detectable Abs differed by previous RT-PCR/antigen status and time elapsed since the diagnostic test.
Assuntos
COVID-19 , SARS-CoV-2 , Humanos , Feminino , Adulto , Masculino , COVID-19/epidemiologia , Colômbia/epidemiologia , Estudos Soroepidemiológicos , Estudos Transversais , Imunoglobulina G , Pessoal de Saúde , Recursos Humanos em Hospital , HospitaisRESUMO
La infeccion intraabdominal (IIA) es un reto para el cirujano. El tratamiento consiste en la combinacion de cirugia, antibioticos y cuidado intensivo. Los antibioticos Beta-3- lactámicos juegan un papel importante en el tratamiento. Las penicilinas tienen un gran potencial de accion y, en combinacion con inhibidores de Beta-lactamasas, su poder se aumenta. El presente estudio se diseñó multicentrico y prospectivo para evaluar la eficacia de la Piperacilina/Tazobactam (Tazocin,) en el tratamiento de la IIA; 40 pacientes fueron incluidos en el estudio y tratados con Piperacilina/Tazobactam (4 g/500 mg) cada 8 horas. Todos los pacientes tuvieron peritonitis, 85 por ciento de ellos por causa de apendicitis gangrenosa perforada. La respuesta clinica favorable ocurrio en 97 por ciento de los casos despues de tratamiento con duracion entre 6 y 14 dias. En 71 aislamientos microbiológicos realizados, prevalecio la flora polimicrobiana. Piperacilina/ Tazobactam tuvo una sensibilidad de 93 por ciento para los germenes aislados aerobicos Gram negativos y Gram positivos asi como para anaerobios. Hubo tres cepas resistentes in vitro en los 71 aislamientos: una cepa de Pseudomonas aeruginosa, una cepa de Klebsiella pneumoniae y otra de Citrobacter freundii. La medicacion fue bien tolerada y sus efectos colaterales nulos.
Assuntos
Infecções/cirurgia , Infecções/complicações , Infecções/tratamento farmacológico , Complicações IntraoperatóriasRESUMO
Critically ill patients admitted to an intensive care unit or an emergency ward, frequently need to be transported to different areas within the hospital in order to perform diagnostic procedures. An increased mortality and morbidity risk has been found associated with the transportation of these patients. In order to investigate the effect of the intra-hospitalary transport of our patients on their clinical status this study was conducted. We studied 12 patients admitted to the intensive care unit or the emergency ward; all were on mechanical-assisted ventilation and had been stable for at least six hours prior to transportation. Blood gas and hemodynamic measurements were obtained before, immediately after and thirty minutes after transportation. The most significant changes seen immediately in our patients were an increase in PaCO2 (30.8 +/- 7.35 vs 35.6 +/- 7.49, p less than 0.02) and a decrease in pH (7.36 +/- 0.08 vs 7.31 +/- 0.05, p less than 0.02). Patients with higher pH values prior to their transportation had the most significant change towards acidosis (r = -0.79). All changes reversed thirty minutes after reinstallation of the mechanical ventilation. There was no change in the hemodynamic measurements. We conclude that the transportation of critically ill patients within a hospital is fairly safe if patients are previously stabilized.