RESUMO

Two new aporphinoid alkaloids, (+)-6 S-ocoteine N-oxide and (+)-norocoxylonine, were isolated from the leaves and trunk bark of OCOTEA ACUTIFOLIA (Lauraceae) along with thirteen aporphine analogues, one morphinan alkaloid, and one flavonoid. The aporphine alkaloids (+)-thalicsimidine and (+)-neolitsine are reported for the first time for the genus OCOTEA. The structures of all compounds were established on the basis of 1D- and 2D-NMR spectroscopic techniques, optical rotation and/or mass spectrometry data. The cytotoxic potential of eight of the aporphine alkaloids against four human cancer cell lines (Hep-2, MCF-7, B16-F10 and 786-0) was also evaluated.

Assuntos

Antineoplásicos Fitogênicos/farmacologia , Aporfinas/farmacologia , Neoplasias/tratamento farmacológico , Ocotea/química , Extratos Vegetais/farmacologia , Antineoplásicos Fitogênicos/isolamento & purificação , Antineoplásicos Fitogênicos/uso terapêutico , Aporfinas/química , Aporfinas/isolamento & purificação , Linhagem Celular Tumoral , Humanos , Estrutura Molecular , Fitoterapia , Casca de Planta , Extratos Vegetais/química , Extratos Vegetais/uso terapêutico , Folhas de Planta