RESUMO
BACKGROUND: The authors aimed to confirm the depth of six mm in order to achieve an optimal eradication of the lesion. MATERIALS AND METHODS: This is a retrospective observational study of 94 cervical surgical pieces from women aged 17 to 22 years with a cyto-colpo-histopathological diagnosis of high-grade squamous cervical intraepithelial neoplasia (CIN II and/or CIN III) submitted to large loop excision of transformation zone (LLETZ). The glandular crypts and margins, both exposed or not to CIN, were assessed. The compromise and the maximum depth of the glandular crypts were noticed. RESULTS: After LLETZ, 23 (24.47%) cases presented a neoplasic impairment of endocervical margin and ten (10.64%) of the ectocervical margin. The largest noticed crypt measured 4.500 mm and the shortest 0.100 mm, with an average of 2.148 mm. CONCLUSIONS: Squamous CIN more frequently show the exposure of surgical margins to LLETZ. The deeper location of glandular crypts in the cases studied was 4.500 mm, while the largest neoplastic extension was 3.000 mm.The therapeutic method depends on this knowledge.
Assuntos
Colo do Útero/cirurgia , Displasia do Colo do Útero/cirurgia , Neoplasias do Colo do Útero/cirurgia , Adolescente , Adulto , Idoso , Feminino , Humanos , Pessoa de Meia-Idade , Estudos Retrospectivos , Neoplasias do Colo do Útero/patologia , Displasia do Colo do Útero/patologiaRESUMO
PURPOSE: This study aimed to evaluate the immunoexpression of granzyme B and vascular endothelial growth factor (VEGF) in the variants of cervical squamous intraepithelial neoplasia. METHODS: Granzyme B immunohistochemical expression was studied in the epithelium, stroma and in both the epithelium + stroma of 142 fragments of uterine cervix; there were 34 grade 1 cervical intraepithelial neoplasias (CIN 1), 36 grade 2 cervical intraepithelial neoplasias (CIN 2), 33 grade 3 cervical intraepithelial neoplasias (CIN 3) and 39 uterine cervix fragments without abnormalities - control group. Immunoexpression of VEGF was studied in 160 uterine cervix fragments, with 43 grade 1 cervical intraepithelial neoplasias (CIN 1), 33 grade 2 cervical intraepithelial neoplasias (CIN 2), 31 grade 3 cervical intraepithelial neoplasias (CIN 3) and 53 uterine cervix fragments without abnormalities--control group. RESULTS: In the stroma, immunoexpression of granzyme B in grade 1 cervical intraepithelial neoplasias was smaller than in grade 3 cervical intraepithelial neoplasias. High VEGF immunoexpression was found in grade 3 cervical intraepithelial neoplasias while it was low in grade 1 cervical intraepithelial neoplasias and in the control group. CONCLUSION: The higher the severity of the cervical intraepithelial lesion, the higher the immunoexpression of granzyme B. A progressive increase in VEGF immunoexpression was found in the intense grade, according to the severity of the cervical intraepithelial neoplasia.
Assuntos
Carcinoma de Células Escamosas/química , Colo do Útero/química , Granzimas/análise , Displasia do Colo do Útero/química , Neoplasias do Colo do Útero/química , Fatores de Crescimento do Endotélio Vascular/análise , Feminino , Humanos , Imuno-HistoquímicaRESUMO
PURPOSE: To study the relationship between topoisomerase IIalpha, active caspase-3 expressions and HPV DNA in uterine cervices with low-grade squamous intraepithelial lesions (LSIL). METHODS: Forty women with LSIL and 32 without cervical neoplasia diagnosed through cytologic and histopathologic examination were evaluated regarding topoisomerase IIalpha and active caspase-3 expressions and HPV DNA detection using PCR (GP5/GP6) in cervicovaginal smears. RESULTS: The mean percentage of cells immunomarked by topoisomerase in the group with LSIL was 11.62% while in the control it was 4.13% (p < 0.0001). In the presence of HPV DNA, topoisomerase expression was higher in the group with productive viral infection than in nonneoplastic tissue (p = 0.004). Caspase-3 expression was observed in 17 patients with LSIL (42.5%) and in five without cervical neoplasia (15.63%). CONCLUSION: The use of topoisomerase IIalpha and active caspase-3 in cervical biopsies may help to define the prognosis of HPV cervical infection.
Assuntos
Antígenos de Neoplasias/análise , Biomarcadores Tumorais/análise , Carcinoma de Células Escamosas/diagnóstico , Caspase 3/análise , DNA Topoisomerases Tipo II/análise , Proteínas de Ligação a DNA/análise , Neoplasias do Colo do Útero/diagnóstico , DNA Viral/análise , Progressão da Doença , Feminino , Humanos , Papillomaviridae/genética , Infecções por Papillomavirus/complicações , PrognósticoRESUMO
The dopamine agonist pergolide was evaluated in the treatment of 42 men who manifested cocaine dependence in a single-blind, 4-week-long placebo-controlled study, during 1998-1999 in São Paulo, Brazil. The patients were randomly assigned to two groups: the first group received pergolide (0.05-0.2 mg per day) and the second group received placebo (one to four tablets per day). Urine toxicology screens were obtained. The groups were compared in terms of depressive symptoms, "craving," use of cocaine, side effects of medications, results of urine tests, and retention in treatment. At 3 months' follow-up, the participants were reassessed. No differences were found between the two groups.
Assuntos
Assistência Ambulatorial , Transtornos Relacionados ao Uso de Cocaína/tratamento farmacológico , Agonistas de Dopamina/uso terapêutico , Pergolida/uso terapêutico , Adulto , Brasil , Transtornos Relacionados ao Uso de Cocaína/urina , Agonistas de Dopamina/administração & dosagem , Seguimentos , Humanos , Masculino , Pergolida/administração & dosagem , Placebos , Método Simples-CegoRESUMO
Objetivos: Partindo das definiçoes das Síndromes Delirantes de Falso Reconhecimento, tendo como principais modelos as Síndromes de Capgras e Frégoli, os autores fizeram uma revisao dos aspectos psicopatológicos envolvidos nesses quadros. Métodos: Foi realizado um levantamento da Literatura fenomenológica clássica e posterior adaptaçao de um modelo neuropsicológico que aprofunde o entendimento desses quadros, geralmente negligenciados pela literatura ou tratados como extravagências de psicopatólogos antigos. Conclusoes: O entendimento das Síndromes Delirantes de Falso Reconhecimento, no entender dos autores, pode ser de grande valia para formar novos conceitos no estudo dos quadros psiquiátricos delirante-alucinatórios maiores, principalmente das correlaçoes entre Sensaçao, Percepçao e Atribuiçao de Significado.