RESUMO

To assess the effect of different doses of Plantago psyllium mucilage on glucose tolerance test, four oral glucose tolerance tests were performed to eight healthy volunteers. Glucose load (75 g) was mixed with 0 (control test), 10.20 and 30 g of mucilage. Serum glucose levels were measured at 0, 30, 60, 120 and 180 minutes. Maximum peak of glucose at 30 minutes, and the area under the curve of glucose were significantly lower in the test with 20 and 30 g of mucilage than the tests with 0 and 10g. There was a significant relationship (r = 0.44 p less than 0.025) between the dose of P. psyllium mucilage and its attenuating effect of hyperglycemia.

Assuntos

Teste de Tolerância a Glucose , Psyllium/farmacologia , Adulto , Relação Dose-Resposta a Droga , Glucose/farmacocinética , Humanos , Absorção Intestinal/efeitos dos fármacos , Masculino , Psyllium/administração & dosagem