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Objetivo: O Cisto Dentígero (CDT) é o tipo mais comum dos cistos odontogênicos de desenvolvimento e o segundo mais frequente entre todos que ocorrem nos maxilares. E uma lesão benigna, radiolúcida, geralmente unilocular, prevalente no sexo masculino, nas três primeiras décadas de vida e com uma maior ocorrência na mandíbula. Possui crescimento lento e assintomático e sua etiopatogenia ainda é considerada desconhecida. Este trabalho tem como objetivo relatar dois casos clínicos de cistos dentígeros, o primeiro em um paciente de 50 anos e o segundo, em uma paciente de 11 anos, ambos localizados em mandíbula e envolvendo molares. Relato de caso: O método utilizado para o tratamento dessa lesão foi a descompressão, no qual foi criada uma comunicação entre o cisto e a cavidade oral, colocando um dispositivo para o condicionamento de sua drenagem e posterior enucleação da lesão e do dente envolvido. Este tratamento, por ser menos invasivo, promove uma maior preservação das estruturas saudáveis adjacentes e consequentemente, um pós-operatório mais favorável. Conclusão: Portanto, é de total importância que o profissional esteja apto para realizar este tipo de procedimento e tenha conhecimento para realizar a técnica, para que assim, o risco de complicações trans e pós-operatórias seja diminuído... (AU)

Objective: The Dentigerous Cyst (DTC) is the most common type of developmental odontogenic cyst and the second most frequent among all that occur in the jaws. It is a benign, radiolucent, usually unilocular lesion, prevalent in males, in the first three decades of life and with a greater occurrence in the mandible. It has slow and asymptomatic growth and its etiopathogenesis is still considered unknown. This paper aims to report two clinical cases of dentigerous cysts, the first in a 50-year-old patient and the second in an 11-year-old patient, both located in the mandible and involving molars. Case report: The method used to treat this lesion was decompression, in which a communication was created between the cyst and the oral cavity, placing a device to condition its drainage and subsequent enucleation ofthe lesion and the tooth involved. This treatment, being less invasive, promotes greater preservation of adjacent healthy stmctures and, consequently, a more favorable postoperative peñod. Conclusion: Therefore, it is of utmost importance that the professional is able to perform this type of procedure and has the knowledge to perform the technique, so that the risk of trans and postoperative complications is reduced... (AU)

Objetivo: El Quiste Dentígero (CDT) es el tipo más común de quiste odontogénico del desarrollo y el segundo más frecuente entre todos 10s que se presentan en 10s maxilares. Es una lesión benigna, radiolúcida, generalmente unilocular, prevalente en el sexo masculino, en Ias tres pñmeras décadas de Ia vida y con mayor incidencia en Ia mandíbula. Tiene un crecimiento lento y asintomático y su etiopatogenia aún se considera desconocida. Este trabajo tiene como objetivo reportar dos casos clínicos de quistes dentígeros, el primero en un paciente de 50 años y el segundo en un paciente de 11 años, ambos localizados en Ia mandíbula y afectando molares. Caso clínico: El método utilizado para el tratamiento de esta lesión fue Ia descompresión, en Ia que se creaba una comunicación entre el quiste y Ia cavidad bucal, colocando un dispositivo para condicionar su drenaje y posterior enucleación de Ia lesión y del diente afectado. Este tratamiento, al ser menos invasivo, favorece una mayor conservación de Ias estmcturas sanas adyacentes y, en consecuencia, un postoperatorio más favorable. Conclusión: Por Io tanto, es de suma importancia que el profesional sea capaz de realizar este tipo de procednmento y tenga 10s conocnmentos para realizar Ia técnica, de manera que se reduzca el riesgo de complicaciones trans y postoperatorias... (AU)

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[This corrects the article DOI: 10.1016/j.ekir.2024.02.994.].

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The current investigation was conducted to investigate the effects of different particle sizes of corn and stocking densities on performance, carcass traits and gastrointestinal tract (GIT) development of Muscovy ducks in housing. 200 Muscovy ducks were distributed in a factorial scheme (2 × 2) where the treatments were constituted by two stocking densities (2 or 3 birds/m2) and two particle sizes of corn (6 or 8 mm), with five replicates of 10 birds each. At 1, 35, 70, and 90 days old, Muscovy ducks were slaughtered to evaluate the development of heart and GIT. Muscovy ducks managed in the density of 3 birds/m2 presented higher (P < 0.05) GIT development, performance and carcass traits regardless of age evaluated. In the same way, Muscovy ducks fed diets using a particle size of corn of 6 mm (Mean Geometric Diameter (MGD) = 781 µm) presented higher (P < 0.05) GIT development, performance and carcass traits regardless of age evaluated. Conclusively, the stocking density of 3 birds/m2 and the particle size of corn of 6 mm (MGD = 781 µm) were considered ideal recommendations for Muscovy ducks, providing higher GIT development, which resulted in better performance and carcass traits.

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INTRODUÇÃO: A fração de ejeção do ventrículo esquerdo (FEVE) é o parâmetro utilizado para a classificação dos diferentes fenótipos de insuficiência cardíaca (IC). Embora pacientes portadores de IC com FEVE reduzida (ICFER) e evidência de bloqueio de ramo esquerdo (BRE) possam ser considerados para a Terapia de Ressincronização Cardíaca (TRC), há uma taxa de aproximadamente 30% de não-respondedores. Nesse contexto, é fundamental a avaliação de novas técnicas capazes de identificar subgrupos com maior risco de desfechos e que devem ser priorizados para a TRC. OBJETIVO: Avaliar a FEVE com o Global Longitudinal Strain (GLS) na predição de eventos maiores em candidatos à TRC. MÉTODOS: Foram incluídos 99 pacientes candidatos à TRC (ICFER com FEVE≤35% e padrão de BRE no ECG), avaliados no período entre fevereiro de 2008 e outubro de 2012 com follow up de 8 anos. As análises foram segmentadas em grupos com eventos combinados: internação por IC, óbito e/ou transplante cardíaco. RESULTADOS: Pacientes com desfecho apresentaram uma FEVE=26,2(±0,05)% e GLS=-13,9(±12,3)%, enquanto pacientes sem desfecho apresentaram FEVE=27,6(±0,05)% e GLS=-16,2(±7,2)%. A diferença entre os grupos foi estatisticamente significante para o GLS (p=0,04), mas sem significância para FEVE (p=0,07) (Figura 1). À análise de Kaplan-Meier utilizando um valor de corte do módulo de GLS<-16%, observou-se uma diferença significante nas curvas de sobrevida com significância pelo teste de log-rank (p=0.005) (Figura 2). CONCLUSÃO: O GLS é uma ferramenta com potencial uso na re-estratificação de pacientes com ICFER candidatos à TRC. Esse recurso além de descrever uma piora da evolução, pode também ajudar na decisão dos grupos que se beneficiariam de uma intervenção mais precoce.

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Background: Arterial hypertension treatment guided by central blood pressures (CPB) rather than peripheral blood pressures (PBP) measurement has the potential to show greater effectiveness in preventing or even regressing stiffness and target organ damage (TOD). Objective: This study aimed to compare the parameters of CBP and PBP measurements, arterial stiffness, TOD and renal profile in patients with anti-hypertensive treatment guided by CBP or PBP targets. Methods: A randomized clinical trial was conducted in central group (CG) and peripheral group (PG). Patients were randomized, evaluated every 3 months for BP and antihypertensive adjustments during a one-year follow up. The procedures in V1 and V5: anthropometric assessment; CBP/PBP measurements, carotid ultrasound; echocardiography; laboratory tests. Paired and unpaired t-tests and the χ2 were used (significance level: 5%). Results: The study evaluated 59 participants (30CG/29PG). The augmentation index (AIx) was higher in the CG (27.3% vs. 20.3%, p = 0.041). Intergroup analysis has found central diastolic BP lower in the CG (78.9 vs. 84.3 mmHg, p = 0.024) and the Alx difference between groups ceased to exist after a one-year follow-up. Intragroup comparisons, after intervention, showed a lower frequency of changed PWV (p < 0.001) and LVMI (p = 0.018) in the CG. The PG showed a higher frequency of changed PWV (p < 0.001) and LVMI (p = 0.003). Conclusion: The intervention guided by central BP reduced the central diastolic BP and AIx compared to the PG. There was a reduction in the frequency of changed PWV and LVMI in the CG.

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Abstract Background Arterial stiffness and hypertension are strong predictors of cardiovascular disease and mortality. Angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) are first-line antihypertensive agents in reducing blood pressure and arterial stiffness. Objective The objective of this study was to compare the effects of ACEI and ARB in reducing arterial stiffness and preventing target organ damage in patients with hypertension. Methods This observational study included 654 participants who attend routine consultations at an outpatient hypertension clinic in 2 university hospitals. Patients were interviewed, and they underwent central and peripheral blood pressure measurements. Doppler echocardiography, carotid ultrasound, biochemical tests, and anthropometric parameters were carried out. Shapiro-Wilk, chi-square, and Fisher's exact test were used. A significance level of 5% was adopted. Results A total of 659 participants were evaluated in the study (398 from the ARB group and 256 from the ACEI group). Age, body mass index (BMI), central and peripheral blood pressure measurements, pulse wave velocity (PWV), left ventricular mass index, and carotid intima-media thickness did not show differences between the groups (p > 0.05). After linear regression analysis, the ACEI group had lower values of total vascular resistance (TVR) (p = 0.003) and augmentation pressure (p = 0.008), when compared to the ARB group. Conclusion This study showed that the ACEI group had a greater reduction in augmentation pressure and PWV. There were no differences between the groups regarding the improvement of outcomes related to central arterial pressure, PWV, and cardiac and vascular target organ damage.

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Background: The Parkinson's Disease-Cognitive Rating Scale (PD-CRS) assesses posterior-cortical and frontal-subcortical cognitive functioning and distinguishes mild cognitive impairment in Parkinson's disease (PD-MCI); however, it was not evaluated in Brazil. Objectives: To investigate PD-CRS's reliability, validity, normative data, and accuracy for PD-MCI screening in Brazil. Methods: The effects of age, education, and sex on PD-CRS scores were explored. The instrument was tested in 714 individuals (53% female, 21-94 years), with a broad range of education and no neurodegenerative disorder. Trail Making, Consonant Trigrams, Five-Point, and semantic fluency tests were administered for comparison. A second study enrolled patients with PD and intact cognition (n = 44, 59.75 ± 10.79 years) and with PD-MCI (n = 25, 65.76 ± 10.33 years) to investigate criterion validity. PD-CRS subtests were compared with the Cambridge Automated Neuropsychological Battery memory and executive tasks. Results: PD-CRS was unidimensional and reliable (McDonald's ω = 0.83). Using robust multiple regressions, age, and education predicted the total and derived scores in the normative sample. At the 85-point cutoff, PD-MCI was detected with 68% sensitivity and 86% specificity (area under the curve = 0.870). PD-CRS scores strongly correlated with executive and verbal/visual memory tests in both normative and clinical samples. Conclusions: This study investigated the applicability of PD-CRS in the Brazilian context. The scale seems helpful in screening for PD-MCI, with adequate internal consistency and construct validity. The PD-CRS variance is influenced by age and educational level, a critical issue for cognitive testing in countries with educational and cultural heterogeneity.

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ABSTRACT Introduction: Medical planning for mass gathering events is founded on the structuring of assistance to the population involved and the preservation of the response capacities of the local healthcare system. Large sporting events attended by crowds are increasingly common in society. These events have been shown to be dangerous, generating higher incidences of injuries and illnesses than usual. Thus, planning and the interaction among various public and private sectors are required for the prevention of and response to emergencies and incidents involving multiple victims. Methods: Recently published studies on medical planning for large sports events and current federal agency legislation were selected to conduct an updated review on the subject. Results: After reading titles and abstracts, 159 papers were chosen for a full reading, 50 of which met the eligibility criteria and were included as the basis for this review. The size of the audience, the weather, and the behavior of the crowd seem to contribute significantly to the estimated need for resources in sporting events. Conclusion: Mass events require planning for prevention and to strengthen the resilience of host communities. There is a still a lack of evidence that these events increase the risk of the mass spreading of disease. Level of Evidence: V; Expert opinion .

RESUMEN Introducción: La planificación médica de eventos masivos tiene como pilares la estructuración de la atención a la población involucrada y la preservación de las capacidades de respuesta del sistema local de salud. Los grandes eventos deportivos a los que asisten multitudes son cada vez más comunes en la sociedad. Estos eventos han demostrado ser peligrosos, generando una mayor incidencia de lesiones y enfermedades de lo habitual. Por lo tanto, es necesaria la planificación y la interacción de diversos sectores, públicos y privados, para la prevención y respuesta a emergencias o incidentes con múltiples víctimas. Métodos: Se seleccionaron estudios recientes publicados sobre la planificación médica de grandes eventos deportivos y la legislación vigente en organismos federales con el objetivo de realizar una revisión actualizada sobre el tema. Resultados: Después de leer los títulos y resúmenes, se eligieron 159 artículos para lectura completa y 50 cumplieron los criterios de elegibilidad y se utilizaron como base para esta revisión. El tamaño del público, las condiciones climáticas y el comportamiento de la multitud parecen contribuir significativamente a la estimación de los requisitos de recursos en los eventos deportivos. Conclusión: Los eventos masivos requieren una planificación para la prevención y el fortalecimiento de la resiliencia de las comunidades anfitrionas. Todavía no hay pruebas de que estos eventos aumenten el riesgo de propagación masiva de enfermedades. Nivel de Evidencia: V; Opinión experta .

RESUMO Introdução: O planejamento médico para eventos de massa tem como pilares a estruturação dos atendimentos à população envolvida e a preservação da capacidade de resposta do sistema de saúde local. Grandes eventos esportivos frequentados por multidões são cada vez mais comuns na sociedade. Esses eventos têm se mostrado perigosos, gerando maiores incidências de lesões e doenças do que o habitual. Dessa forma, é necessário planejamento e interação de diversos setores, públicos e privados, para prevenção e resposta à ocorrência de emergências ou incidentes com múltiplas vítimas. Métodos: Foram selecionados trabalhos recentes publicados sobre o planejamento médico para grandes eventos esportivos e a legislação vigente em órgãos federais com o objetivo de realizar uma revisão atualizada sobre o assunto. Resultados: Após a leitura de títulos e resumos, 159 trabalhos foram escolhidos para leitura integral e 50 preencheram os critérios de elegibilidade e foram usados como base para esta revisão. O tamanho do público, as condições climáticas e o comportamento da multidão parecem contribuir significativamente para a estimativa da necessidade de recursos em eventos esportivos. Conclusão: Eventos de massa exigem planejamento para prevenção e fortalecimento da resiliência das comunidades anfitriãs. Ainda faltam evidências de que esses eventos aumentem o risco de propagação maciça de doenças. Nível de evidência: V; Opinião do especialista .

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One of the significant challenges today in the brain-machine interfaces that use invasive methods is the stability of the chronic record. In recent years, polymer-based electrodes have gained notoriety for achieving mechanical strength values close to that of brain tissue, promoting a lower immune response to the implant. In this work, we fabricated fully polymeric electrodes based on PEDOT:PSS for neural recording in Wistar rats. We characterized the electrical properties and both in vitro and in vivo functionality of the electrodes. Additionally, we employed histological processing and microscopical visualization to evaluate the tecidual immune response at 7, 14, and 21 days post-implant. Electrodes with 400-micrometer channels showed a 12 dB signal-to-noise ratio. Local field potentials were characterized under two conditions: anesthetized and free-moving. There was a proliferation of microglia at the tissue-electrode interface in the early days, though there was a decrease after 14 days. Astrocytes also migrated to the interface, but there was not continuous recruitment of these cells in the tissue; there was inflammatory stability by day 21. The signal was not affected by this inflammatory action, demonstrating that fully polymeric electrodes can be an alternative means to prolong the valuable time of neural recordings.

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Resumo Fundamento: A rigidez arterial é um forte preditor de doença cardiovascular (DCV). Medidas de gordura corporal, como a circunferência da cintura (CC), têm sido associadas à DCV na idade adulta. Objetivos: O objetivo deste estudo foi avaliar a associação da rigidez arterial, medida por tonometria de aplanação-Sphygmocor, com a CC. Métodos: Estudo observacional com 240 participantes que fazem consultas de rotina no ambulatório de clínica médica de um hospital universitário. Os participantes foram entrevistados e tiveram as medidas centrais da pressão arterial (MCPA), parâmetros antropométricos, gordura abdominal e gordura visceral mensurados. Foram u tilizados os testes t pareado e não pareado e qui-quadrado. Foi a dotado nível de significância de 5%. Resultados: Dos 240 participantes, 51,82% era do sexo masculino com idade média de 59,71(±14,81) anos e CC média de 99,87 (±11,54) cm. Os valores médios das MCPA foram: Pressão arterial central (PAC) = 130,23 (91-223) mmHg, velocidade de onda de pulso (VOP) = 9,8 (5,28-19,6)m/s e Augmentation Index [Índice de amplificação (AI)] = 29,45 (-14-60). A VOP e a PAC foram altamente correlacionadas com uma CC com p<0,001 e p=0,02, respectivamente; porém, a mesma correlação positiva não foi encontrada entre a CC e o AI (p=0,06). Conclusão: O presente estudo mostrou uma associação positiva entre a CC e a rigidez arterial, através da velocidade de onda de pulso carotídeo femoral (VOP-cf) e o AI, sendo mais forte com a VOP-cf, sugerindo a avaliação do efeito da CC na saúde vascular como método de auxílio no tratamento precoce das DCV e na prevenção de desfechos clínicos.

Abstract Background: Arterial stiffness is a strong predictor of cardiovascular disease (CVD). Body fat measures such as waist circumference (WC) have been associated with CVD in adulthood. Objectives: The objective of this study was to evaluate the association of arterial stiffness, measured by applanation tonometry-Sphygmocor, with WC. Methods: Observational study with 240 participants who make routine consultations at the outpatient clinic of a university hospital. Participants were interviewed and had central blood pressure measurements (CBPM), anthropometric parameters, abdominal fat and visceral fat measured. Paired and unpaired t and chi-square tests were used. A significance level of 5% was adopted. Results: Of the 240 participants, 51.82% were male with a mean age of 59.71(±14.81) years and a mean WC of 99.87 (11.54) cm. Mean CBPM values were: Central arterial pressure (CAP) = 130.23 (91-223) mmHg, pulse wave velocity (PWV) = 9.8 (5.28-19.6)m/s and Augmentation Index [Amplification Index (AI)] = 29.45 (-14-60). PWV and CAP were highly correlated with WC with p<0.001 and p=0.02, respectively; however, the same positive correlation was not found between WC and AI (p=0.06). Conclusion: The present study showed a positive association between WC and arterial stiffness, through the femoral carotid pulse wave velocity (cf-PWV) and AI, being stronger with cf-PWV, suggesting the evaluation of the effect of WC in vascular health as a method of aid in the early treatment of CVD and in the prevention of clinical outcomes.

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BACKGROUND: Arterial stiffness is a strong predictor of cardiovascular disease (CVD). Body fat measures such as waist circumference (WC) have been associated with CVD in adulthood. OBJECTIVES: The objective of this study was to evaluate the association of arterial stiffness, measured by applanation tonometry-Sphygmocor, with WC. METHODS: Observational study with 240 participants who make routine consultations at the outpatient clinic of a university hospital. Participants were interviewed and had central blood pressure measurements (CBPM), anthropometric parameters, abdominal fat and visceral fat measured. Paired and unpaired t and chi-square tests were used. A significance level of 5% was adopted. RESULTS: Of the 240 participants, 51.82% were male with a mean age of 59.71(±14.81) years and a mean WC of 99.87 (11.54) cm. Mean CBPM values were: Central arterial pressure (CAP) = 130.23 (91-223) mmHg, pulse wave velocity (PWV) = 9.8 (5.28-19.6)m/s and Augmentation Index [Amplification Index (AI)] = 29.45 (-14-60). PWV and CAP were highly correlated with WC with p<0.001 and p=0.02, respectively; however, the same positive correlation was not found between WC and AI (p=0.06). CONCLUSION: The present study showed a positive association between WC and arterial stiffness, through the femoral carotid pulse wave velocity (cf-PWV) and AI, being stronger with cf-PWV, suggesting the evaluation of the effect of WC in vascular health as a method of aid in the early treatment of CVD and in the prevention of clinical outcomes.

FUNDAMENTO: A rigidez arterial é um forte preditor de doença cardiovascular (DCV). Medidas de gordura corporal, como a circunferência da cintura (CC), têm sido associadas à DCV na idade adulta. OBJETIVOS: O objetivo deste estudo foi avaliar a associação da rigidez arterial, medida por tonometria de aplanação-Sphygmocor, com a CC. MÉTODOS: Estudo observacional com 240 participantes que fazem consultas de rotina no ambulatório de clínica médica de um hospital universitário. Os participantes foram entrevistados e tiveram as medidas centrais da pressão arterial (MCPA), parâmetros antropométricos, gordura abdominal e gordura visceral mensurados. Foram u tilizados os testes t pareado e não pareado e qui-quadrado. Foi a dotado nível de significância de 5%. RESULTADOS: Dos 240 participantes, 51,82% era do sexo masculino com idade média de 59,71(±14,81) anos e CC média de 99,87 (±11,54) cm. Os valores médios das MCPA foram: Pressão arterial central (PAC) = 130,23 (91-223) mmHg, velocidade de onda de pulso (VOP) = 9,8 (5,28-19,6)m/s e Augmentation Index [Índice de amplificação (AI)] = 29,45 (-14-60). A VOP e a PAC foram altamente correlacionadas com uma CC com p<0,001 e p=0,02, respectivamente; porém, a mesma correlação positiva não foi encontrada entre a CC e o AI (p=0,06). CONCLUSÃO: O presente estudo mostrou uma associação positiva entre a CC e a rigidez arterial, através da velocidade de onda de pulso carotídeo femoral (VOP-cf) e o AI, sendo mais forte com a VOP-cf, sugerindo a avaliação do efeito da CC na saúde vascular como método de auxílio no tratamento precoce das DCV e na prevenção de desfechos clínicos.

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The low natural fertility and compaction of agricultural soils in the Cerrado are the main limitations for agricultural production. Changes in management systems are necessary to optimize the use of natural resources. The objective of this study was to map and evaluate the presence of penetration resistance and its relationship with soil chemical attributes in pasture areas in the Cerrado of Piauí. The experiment was carried out in the municipality of Corrente-PI, Brazil. The areawas divided into two sub-areas of 0.5 ha each: the first is remaining vegetation and the second is pasture. Fifty soil samples were collected in the 0.00-0.20 and 0.20-0.40 mlayers, with a sampling grid of 10 x 10 m. The pHin water, organic matter, calcium, magnesium,and soil penetration resistance were analyzed. The introduction of animals in the pasture area increased soil compaction by 2%. Chemical attributes, pH, organic matter, calcium and magnesium vary according to soil compaction by 2%. The native forest area has soil penetration resistance at acceptable levels (<2MPa)and availability of nutrientsat adequate levels. The maps of variability of organic matter, calcium, magnesium and penetration resistanceshowed the heterogeneity of the areas, allowing decisions based on specific management zones, localized application of nutrients and decompaction,and recovery of areas with inefficient management.(AU)

A baixa fertilidade natural e a compactação dos solos agrícolas do cerrado são as principais limitações para produção agropecuária. Mudanças nos sistemas de manejo são necessárias para otimização do uso de recursos naturais. O objetivo do estudo foi mapear e avaliar a presença da resistência a penetração e sua relação com os atributos químicos do solo em áreas de pastagens no cerrado piauiense. O experimento foi realizado no município de Corrente-PI. A área foi dividida em duas subáreas de 0,5 ha cada: a primeira é de vegetação remanescente, e a segunda de pastagem. Foram retiradas 50 amostras de solos nas camadas: 0.00-0.20 e 0.20-0.40 m, com malha amostral de 10 x 10 m. Foramanalisados, pH em água, matéria orgânica, cálcio, magnésio e resistência do solo a penetração. A introdução de animais na área de pastagem, aumentou a compactação do solo em 2%. Os atributos químicos, pH, matéria orgânica, cálcio e magnésio, variam de conforme a compactação do solo em 2%. A área de mata nativa apresenta resistência do solo à penetração em níveis aceitáveis (<2MPa)e disponibilidade de nutrientes em níveis adequados. Os mapas de variabilidade espacial mostraram a heterogeneidade das áreas,permitindo decisões baseadas em zonas específicas de manejo, aplicação de nutrientes e descompactação localizada e recuperação das áreascom manejo ineficiente.(AU)

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Non-standard diesel blends can be harmful to the environment and human health. In this context, a simple analytical method to estimate the biodiesel mixture ratio in diesel was developed based on impedance spectroscopy (IS) associated with interdigitated sensors. In this article, four different interdigitated sensors with varied comb spacing (G) were simulated using the COMSOL Multiphysics software. Based on finite element simulations, four interdigitated electrode architectures were manufactured and evaluated. The best geometry was chosen according to theoretical data simulations, and its interdigitated electrodes were manufactured for the compositional evaluation of pseudo-binary biodiesel-diesel mixtures. According to the X-ray powder diffraction technique, the deposition of the conductive layer (Au0) over the surface of the dielectric substrate (SiO2) did not alter its phase composition. In the analysis of AFM and SEM, it was possible to observe irregular edges on the electrodes, possibly related to the manufacturing process of the thin layers and mechanical stability. Another characteristic observed in the AFM images was the height of the step of the gold layer of the sensor. Several cross sections were obtained, and the mean step value was 225.71 ± 0.0032 nm. Although there were differences in the roughness, the whole sensor had nanometric roughness. Based on the finite element method simulation performed, it can be assumed that the geometric parameters more suitable for the manufacturing of the electrode are W = 20 µm, L = 1000 µm, G = 50 µm, and N = 40 digits. The electrical characterization performed by impedance spectroscopy showed that we could differentiate between biodiesel and diesel fuels and their pseudo-binary mixtures in the low-frequency region.

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Este relato de caso teve como objetivo descrever a realização de um procedimento cirúrgico de remoção de um odontoma composto em um paciente pediátrico, e a partir disto elucidar a importância do diagnóstico precoce, assim como o seu tratamento. Um paciente do sexo masculino de 8 anos com ausência de erupção dos germes dentários 21 e 22 e retenção prolongada dos dentes 61 e 62. Foi realizado o planejamento cirúrgico de remoção do tumor e dos elementos dentários não esfoliados. Durante o acompanhamento de 6 meses do paciente houve a erupção do dente 22 e o 21 permaneceu retido, o qual se encontra em acompanhamento ortodôntico para manutenção do espaço e possível tracionamento orto-cirúrgico. Portanto, o diagnóstico e investigação de situações clínicas e radiográficas sugestivas de odontomas são imprescindíveis para evitar danos futuros a dentição permanente... (AU)

This case report aimed to describe the performance of a surgical procedure of removal of a compound odontoma in a pediatric patient, and from this to elucidate the importance of early diagnosis and treat ment. A male patient 8 years old without no eruption of tooth germs 21 and 22 and prolonged retention of teeth 61 and 62. Surgical planning was carried out to remove the tumor and the unexfoliated teeth. During the 6-month follow-up of the patient, the eruption of tooth 22 and 21 remained retained, which is under orthodontic follow-up to space maintenance and possible ortho-surgical traction. Therefore, the diagnosis and investigation of clinical and radiographic situations suggestive of odontomas are essential for prevent future damage to permanent teeth.removal of a compound odontoma in a pediatric patient, and from this to elucidate the importance of early diagnosis and treatment. A male patient 8 years old without no eruption of tooth germs 21 and 22 and prolonged retention of teeth 61 and 62. Surgical planning was carried out to remove the tumor and the unexfoliated teeth. During the 6-month follow-up of the patient, the eruption of tooth 22 and 21 remained retained, which is under orthodon tic follow-up to space maintenance and possible ortho-surgical traction. Therefore, the diagnosis and investigation of clinical and radiographic situations suggestive of odontomas are essential for prevent future damage to permanent teeth... (AU)

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Objective: To systematically review the literature to identify controlled clinical trials evaluating the effectiveness of deep dry needling (DDN) in the treatment of patients with chronic masticatory myofascial pain (MMP).Methods: The sample size for a clinical trial was calculated and involved five patients who consecutively presented for treatment of MMP. The percentage of change in the means of three consecutive measurements of the pressure pain threshold (PPT) of myofascial trigger points (MTPs) was calculated and the statistical significance of this difference evaluated using the Wilcoxon test.Results: Twenty-five studies were considered for inclusion based on title and abstract. Only 2 studies met the inclusion criteria and were used to calculate the sample size. DDN significantly increased (p = 0.04) the PPT in MTP (44.6%) compared with sham procedure (-5.5%).Conclusion: Patients with chronic MMP treated with DDN of MTPs showed an increase in PPT measurements on the experimental side.Abbreviations: CGRP: calcitonin gene-related peptide; DC/TMD: diagnostic criteria for temporomandibular disorders; DDN: deep dry needling; DN: dry needling; LILACS: Latin American and Caribbean Health Sciences; MMP: masticatory myofascial pain; MTP: myofascial trigger point; MTPs: myofascial trigger points; PPT: pressure pain threshold; RCTs: randomized clinical trials; SciELO: Scientific Electronic Library Online; SP: Substance P; TMD: temporomandibular disorders.

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O objetivo do presente trabalho é identificar e descrever o trajeto do ligamento discomaleolar (LDM) através de imagem por ressonância magnética (IRM). Materiais e Métodos: As IMR foram adquiridas de dois participantes da pesquisa através de um aparelho SIGNA Explorer, 1,5 T. Conclusão: A partir delas foi possível observar uma estrutura com direcionamento ascendente com origem na zona bilaminar em direção à região do ouvido médio, após análise, as imagens obtidas sugerem que a estrutura observada seja o LDM

Objective: This article aims to identify and describe the path of the discomaleolar ligament (DML) using magnetic resonance imaging (MRI). Materials and methods: MRIs were acquired from the temporomandibular joint (TMJ) region of two research participants using a 1.5 T SIGNA Explorer device. Conclusion: based on the images, we could observe a structure with an upward direction originating in the bilaminar zone towards the middle ear region. After analysis, the images obtained suggest that the observed structure is the DML.

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Objective: To compare the levels of non-specific physical symptoms and pressure pain threshold (PPT) found in patients with masticatory myofascial pain with those found in patients with temporomandibular arthralgia alone. Methods: The study followed an observational and cross-sectional protocol. A total of 64 female patients were evaluated for the presence of painful TMD, non-specific physical symptom levels, and PPT. Results: The group of patients with masticatory myofascial pain presented a lower mean for PPT as well as a higher mean for standardized T-Scores for non-specific physical symptom levels. Conclusion: Statistically significant differences were found in non-specific physical symptom levels and PPT between patients with an exclusive diagnosis of masticatory myofascial pain and patients with a diagnosis, also exclusive, of temporomandibular arthralgia.

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ABSTRACT Chemical investigation of the aqueous fraction of the ethanol extract from the Brazilian endemic marine sponge Clathria (Clathria) nicoleae Vieira de Barros, Santos & Pinheiro, 2013, Microcionidae, sampled from a 55 m deep rhodolith bed at the Amazon River mouth, led to the isolation of a new hexapeptide, clathriamide (1). HP-20 resin was used to capture compound 1 from the aqueous fraction, which was purified by additional chromatographic steps. The absolute configuration of the amino acids of 1 was determined by advanced Marfey's analysis using 5-fluoro-2,4-dinitrophenyl-Nα-L-tryptophanamide. The amino acid derivatives analyzed by ultra-performance liquid chromatography coupled to a mass spectrometry using a C8 column enabled a good chromatographic resolution of L-Ile and L-allo-Ile, previously unfeasible using C18 column.