RESUMO

The biosynthetic pigment from Chromobacterium violaceum BB-78, 1,3-dihydro-2H-indol-2-one and its derivatives exhibit biological activities such as antimicrobial action, low hemolytic effects on red blood cells and in vitro trypanocide activity. A relatively high cytotoxicity on V-79 hamster fibroblast cells of the biosynthetic pigment was found, although with the methylol derivative the toxicity was almost eliminated. The methylol derivative exhibited similar toxicity as Nifurtimox, a known, commercial trypanocide compound.

Assuntos

Antibacterianos/toxicidade , Chromobacterium/metabolismo , Hemólise , Indóis/toxicidade , Pigmentos Biológicos/toxicidade , Animais , Antibacterianos/isolamento & purificação , Bactérias/efeitos dos fármacos , Linhagem Celular , Sobrevivência Celular/efeitos dos fármacos , Chromobacterium/crescimento & desenvolvimento , Cricetinae , Fibroblastos/efeitos dos fármacos , Indóis/isolamento & purificação , Testes de Sensibilidade Microbiana , Nifurtimox/toxicidade , Pigmentos Biológicos/isolamento & purificação , Trypanosoma cruzi/efeitos dos fármacos , Trypanosoma cruzi/crescimento & desenvolvimento