RESUMO
IMPORTANCE: Reactions to tattoo may simulate common dermatosis or skin neoplasms. Histopathology allows diagnosis and helps determining the level and degree of inflammation associated, consequently orientating treatment. OBJECTIVE: To describe the histological features found in biopsies of cutaneous reactions to tattoo. DESIGN: This study was designed as a multicenter case series. SETTING: All consecutive histopathological samples of tattoos referred from 1992 to 2019 to the Hospital General de Catalunya, Hospital Germans Trias i Pujol, and a private practice, all in Barcelona, Spain, and from the Kempf und Pfaltz Histologische Diagnostik in Zurich, Switzerland were retrieved from the files. PARTICIPANTS AND EXPOSURE: The inclusion criteria were all cosmetic/permanent makeup, artistic/professional, and traumatic tattoos associated with either inflammatory reactions alone and/or with tumors and/or infections. Exclusion criteria were cases without any associated pathologic finding in the place of the ink, amalgam tattoos, and medical or temporary tattoos. MAIN OUTCOMES AND MEASURES: In all patients, clinical features (age, sex, location, tattoo color, and presentation) were recorded. Histological features evaluated included ink color, associated tumors or infections, and inflammatory reaction pattern. Inflammation was graded in low to moderate or severe. RESULTS: From 477 biopsies diagnosed as tattoos, 230 cases from 226 patients met the inclusion criteria. Samples corresponded to 107 male and 120 female subjects and 3 of unknown gender. Median age was 39 years (ranging from 9 to 84 years). Fifty-three samples were referred from centers in Spain and 177 from the center in Switzerland. The series was analyzed in 2 parts: tattoos associated only with inflammatory reactions (117/230) and tattoos associated with tumors or infections (113/230). The most common form of inflammatory pattern associated with tattoo was the fibrosing reaction (79/117, 68%), followed by granulomatous reaction (56/117, 48%), lichenoid reaction (33/117, 28%), epithelial hyperplasia (28/117, 24%), pseudolymphoma (27/117, 23%) and spongiotic reaction (27/117, 23%). Combined features of 2 or more types of inflammatory patterns were seen in 64% cases. CONCLUSIONS AND RELEVANCE: Our series confirms that cutaneous reactions to tattoos are polymorphous. Inflammation tends to present with combined patterns. Infections are tending to decline, and pathologic findings are not specific to ink color or clinical features.
Assuntos
Dermatite/patologia , Dermatopatias Infecciosas/patologia , Neoplasias Cutâneas/patologia , Pele/patologia , Tatuagem/efeitos adversos , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Biópsia , Criança , Cor , Corantes/efeitos adversos , Dermatite/etiologia , Feminino , Granuloma/etiologia , Granuloma/patologia , Humanos , Tinta , Erupções Liquenoides/etiologia , Erupções Liquenoides/patologia , Masculino , Pessoa de Meia-Idade , Pseudolinfoma/etiologia , Pseudolinfoma/patologia , Dermatopatias Infecciosas/etiologia , Adulto JovemRESUMO
Pseudoxanthoma elasticum-like papillary dermal elastolysis is an acquired elastic tissue disorder clinically similar to pseudoxanthoma elasticum in the absence of systemic involvement. Histopathologically, special staining of elastic fibers demonstrates a total or partial band-like loss of elastic fibers in the papillary dermis. Although ultraviolet radiation seems to be one of the main etiological factors in this entity, we report a case of pseudoxanthoma elasticum-like papillary dermal elastolysis on the neck of a woman who wore hijab.
Assuntos
Derme/patologia , Tecido Elástico/patologia , Pseudoxantoma Elástico/patologia , Idoso , Biópsia , Dermoscopia , Feminino , HumanosRESUMO
Abstract Pseudoxanthoma elasticum-like papillary dermal elastolysis is an acquired elastic tissue disorder clinically similar to pseudoxanthoma elasticum in the absence of systemic involvement. Histopathologically, special staining of elastic fibers demonstrates a total or partial band-like loss of elastic fibers in the papillary dermis. Although ultraviolet radiation seems to be one of the main etiological factors in this entity, we report a case of pseudoxanthoma elasticum-like papillary dermal elastolysis on the neck of a woman who wore hijab.
Assuntos
Humanos , Feminino , Idoso , Pseudoxantoma Elástico/patologia , Derme/patologia , Tecido Elástico/patologia , Biópsia , DermoscopiaRESUMO
Abstract Erythroderma as the first manifestation of a solid organ malignancy is rare. The underlying cancer is a challenging condition to diagnose. There are a few cases of erythroderma in cancer patients reported in the literature. We here describe the case of a 70-year-old man who presented with asthenia, weight loss, dry cough and total body erythema with desquamation over the past month. A chest computed tomography scan showed a nodular lesion, which was finally diagnosed as a squamous cell lung carcinoma. To our knowledge, as an erythroderma presentation, only 13 cases have been reported in the literature. This case report demonstrates the need to search for a neoplasm in patients presenting with erythroderma, particularly in the presence of accompanying debilitating symptoms.
Assuntos
Humanos , Masculino , Idoso , Dermatite Esfoliativa/patologia , Neoplasias de Células Escamosas/patologia , Neoplasias Pulmonares/patologia , Síndromes Paraneoplásicas/patologia , Biópsia , Tomografia Computadorizada por Raios X , Dermatite Esfoliativa/etiologia , Neoplasias de Células Escamosas/complicações , Eritema/patologia , Neoplasias Pulmonares/complicaçõesRESUMO
Erythroderma as the first manifestation of a solid organ malignancy is rare. The underlying cancer is a challenging condition to diagnose. There are a few cases of erythroderma in cancer patients reported in the literature. We here describe the case of a 70-year-old man who presented with asthenia, weight loss, dry cough and total body erythema with desquamation over the past month. A chest computed tomography scan showed a nodular lesion, which was finally diagnosed as a squamous cell lung carcinoma. To our knowledge, as an erythroderma presentation, only 13 cases have been reported in the literature. This case report demonstrates the need to search for a neoplasm in patients presenting with erythroderma, particularly in the presence of accompanying debilitating symptoms.
Assuntos
Dermatite Esfoliativa/patologia , Neoplasias Pulmonares/patologia , Neoplasias de Células Escamosas/patologia , Idoso , Biópsia , Dermatite Esfoliativa/etiologia , Eritema/patologia , Humanos , Neoplasias Pulmonares/complicações , Masculino , Neoplasias de Células Escamosas/complicações , Síndromes Paraneoplásicas/patologia , Tomografia Computadorizada por Raios XRESUMO
Lipomatous metaplasia of the upper dermis is a rare phenomenon scarcely described in the literature which has always been identified in the context of inflammatory or neoplastic processes. Microscopically, it should be distinguished from pseudolipomatosis cutis, dermal lipoma, nevus lipomatosus, and focal dermal hypoplasia (Goltz syndrome). This is the first report of the histologic and ultrasound evaluation of a patient with extensive involvement and the description of the coincidental finding of an anomalous nonseptate subcutaneous tissue.
Assuntos
Tecido Adiposo/patologia , Pele/patologia , Tela Subcutânea/patologia , Idoso , Feminino , Humanos , Metaplasia/patologiaRESUMO
The O5 chromosomal inversion has been a cornerstone for understanding different aspects of the American colonization by Drosophila subobscura. To obtain more information of this evolutionary event it is important to know the pattern of bands of this inversion in detail. Comparing this pattern with that of D. melanogaster it is possible to predict which genes are located inside or close to the O5 inversion and use them as genetic markers. In this study, the complete band pattern of the O5 inversion is presented. Furthermore, the most important genes located inside it have been predicted. Finally, a constriction located close to the proximal breakage point of the O5 inversion has been observed many times and its possible genetic significance is discussed