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Brain Res ; 1144: 107-16, 2007 May 04.
Artigo em Inglês | MEDLINE | ID: mdl-17335785

RESUMO

This study was undertaken to verify if repeated long-term separation from dams would affect the development of parameters related to post-traumatic stress disorder (PTSD) after animals are subjected to inescapable shock when adults. Wistar rats were subjected to repeated maternal separation during post-natal days 1-10. When adults, rats from both sexes were submitted to a PTSD model consisting of exposure to inescapable footshock, followed by situational reminders. We observed long-lasting effects of both interventions. Exposure to shock increased fear conditioning. Anxiety-like behavior was increased and exploratory activity decreased by both treatments, and these effects were more robust in males. Additionally, basal corticosterone in plasma was decreased, paralleling effects observed in PTSD patients. Levels of S100B protein in serum and cerebrospinal fluid (CSF) were measured. Levels in serum correlated with the effects observed in anxiety-like behavior, increasing in males exposed to shock, and presenting no effect in females. S100B in CSF was increased in females submitted to maternal separation during the neonatal period. These results suggest that, in rats, an early stress experience such as maternal separation may aggravate some effects of exposure to a stressor during adult age, and that this effect is sex-specific. Additionally, data suggest that the increased S100B levels, observed in serum, have an extracerebral origin, possibly mediated by an increase in the noradrenergic tonus. Increased S100B in brain could be related to its neurotrophic actions.


Assuntos
Comportamento Animal/fisiologia , Privação Materna , Fatores de Crescimento Neural/metabolismo , Proteínas S100/metabolismo , Caracteres Sexuais , Transtornos de Estresse Pós-Traumáticos/metabolismo , Análise de Variância , Animais , Animais Recém-Nascidos , Condicionamento Psicológico/fisiologia , Corticosterona/sangue , Modelos Animais de Doenças , Eletrochoque/efeitos adversos , Comportamento Exploratório/fisiologia , Medo/fisiologia , Feminino , Masculino , Gravidez , Ratos , Ratos Wistar , Subunidade beta da Proteína Ligante de Cálcio S100
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