RESUMO

The derivatives of 3-(4'-bromo-[1,1'-biphenyl]-4-yl)-3-(4-X-phenyl)-N,N-dimethyl-2-propen-1-amine (5a-m) were synthesised through a Friedel-Crafts acylation followed by Wittig reaction. The effects of the compounds on standard strains of Mycobacterium sp. (ATCC) and M. tuberculosis isolated from clinical specimens were evaluated. Also the toxicity was determined on V79 cells line using neutral red uptake (NRU), nucleic acid content (NAC) and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction to measure the cellular viability.

Assuntos

Alcenos/síntese química , Antituberculosos/síntese química , Compostos de Bifenilo/síntese química , Mycobacterium tuberculosis/efeitos dos fármacos , Alcenos/química , Alcenos/farmacologia , Animais , Antituberculosos/química , Antituberculosos/farmacologia , Compostos de Bifenilo/química , Compostos de Bifenilo/farmacologia , Linhagem Celular , Cricetinae , Fibroblastos/citologia , Fibroblastos/efeitos dos fármacos , Pulmão/citologia , Testes de Sensibilidade Microbiana