RESUMO
Two new diterpenoid derivatives 7α,12ß,17-triacetoxy-6ß,19-dihydroxy-13ß,16-spirocicloabiet-8-ene-11,14-dione ( 1: ) and 6ß-acetoxy-3ß,7α,12α-trihydroxy-13ß,16-spirocicloabiet-8-ene-11,14-dione ( 2: ) along with 11 ( 3: - 13: ) miscellaneous compounds were isolated from the leaves of Plectranthus ornatus Codd. Their structures were elucidated by spectroscopic analysis and gauge independent atomic orbitals 13C NMR calculations. The isolated compounds were screened for their effects on intestinal motility using guinea-pig ileum and duodenum and by their cytotoxicity against 4 human cancer cell lines (HCT-116, SF-295, PC-3, and HL-60). Compounds 6: and 9: were moderately cytotoxic against HL-60, whereas 6: and 13: were more active on SF-295 and HCT-116.
Assuntos
Plectranthus , Animais , Diterpenos/farmacologia , Cobaias , Humanos , Estrutura Molecular , Extratos Vegetais/farmacologia , Folhas de PlantaRESUMO
Sheep-raising is a promising activity in the semi-arid of the Brazilian Northeast. However, somebarriers prevent the development of this type of livestock farming, such as the lack of assistance to producersand climatic factors that straight affect herd production. Therefore, it was aimed to contribute to thedevelopment of this activity, suggesting the implementation of reproductive-handling practices in PIVAS. Thework in 2013 was developed in 15 among 22 productive areas intended for production in PIVAS. In 2014 it wassupported 08 productive areas and in 2015, it was accompanied 066 productive areas. There was a significantchange in the frequency of the implementation of some practices suggested by the extension group, for example,in 2014 and 2015, it was reached 100% of acceptance for neonate care and discarding annual rate. Finally,many of the suggested systems have not been complied because of barriers already mentioned.
Assuntos
Animais , Comportamento Reprodutivo/classificação , Ovinos/classificaçãoRESUMO
Sheep-raising is a promising activity in the semi-arid of the Brazilian Northeast. However, somebarriers prevent the development of this type of livestock farming, such as the lack of assistance to producersand climatic factors that straight affect herd production. Therefore, it was aimed to contribute to thedevelopment of this activity, suggesting the implementation of reproductive-handling practices in PIVAS. Thework in 2013 was developed in 15 among 22 productive areas intended for production in PIVAS. In 2014 it wassupported 08 productive areas and in 2015, it was accompanied 066 productive areas. There was a significantchange in the frequency of the implementation of some practices suggested by the extension group, for example,in 2014 and 2015, it was reached 100% of acceptance for neonate care and discarding annual rate. Finally,many of the suggested systems have not been complied because of barriers already mentioned.(AU)