RESUMO

Osteomyelitis is an infectious disease located in the bone or bone marrow. Long-circulating and pH-sensitive liposomes containing a technetium-99m-labeled antibiotic, ceftizoxime, (SpHL-(99m)Tc-CF) were developed to identify osteomyelitis foci. Biodistribution studies and scintigraphic images of bone infection or non infection-bearing rats that had been treated with these liposomes were performed. A high accumulation in infectious foci and high values in the target-non target ratio could be observed. These results indicate the potential of SpHL-(99m)Tc-CF as a potential agent for the diagnosis of bone infections.

Assuntos

Ceftizoxima/análogos & derivados , Compostos de Organotecnécio/farmacocinética , Compostos de Organotecnécio/uso terapêutico , Osteomielite/tratamento farmacológico , Animais , Ceftizoxima/administração & dosagem , Ceftizoxima/química , Ceftizoxima/farmacocinética , Ceftizoxima/uso terapêutico , Modelos Animais de Doenças , Concentração de Íons de Hidrogênio , Lipossomos , Masculino , Estrutura Molecular , Especificidade de Órgãos , Compostos de Organotecnécio/administração & dosagem , Compostos de Organotecnécio/química , Ratos , Ratos Wistar , Staphylococcus aureus/efeitos dos fármacos