RESUMO
BACKGROUND: The patch test is an essential procedure for the investigation of aetiologic diagnosis of allergic contact dermatitis, although it is not yet able to fully reproduce the events of the initial site of contact with the allergen. OBJECTIVES: The aims of the present study are (i) to assess whether removal of the superficial corneous layer results in test positivity differences vs. the traditional technique, (ii) to assess the probable and/or possible and past and/or present sensitivity and relevance for each method, and (iii) to compare specific relevance of nickel sulphate for each method. RESULTS: Concordance of positive reactions was 75.9% (66 of 87), with 21.8% (19 of 87) positivity results on the abraded side only and 2.3% (2 of 87) on the unabraded side (P < 0.05). Concordance of the substances with probable and/or possible and past and/or present relevance was 77.3% (58 of 75) for the abraded side and 21.3% (16 of 75) and 1.3% (1 of 75) for the unabraded side (P < 0.05). Analysis of isolated relevance for nickel sulphate showed 95.6% (22 of 23) concordance. CONCLUSIONS: (i) We found a greater number of positive substances on the abraded side, and when only the 2 + and 3 + reactions were considered, greater relative discordance was also observed; (ii) relevance analysis revealed a statistically significant difference between the two methods; (iii) differences in nickel sulphate test positivity and relevance for the two methods did not reach statistical significance.
Assuntos
Dermatite de Contato/diagnóstico , Testes do Emplastro/métodos , Adolescente , Adulto , Idoso , Distribuição de Qui-Quadrado , Criança , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Sensibilidade e Especificidade , Fita CirúrgicaRESUMO
We report a case of acute generalized exanthematous pustulosis (AGEP) in a 64-year-old woman, associated with the use of bamifylline. To the best of our knowledge there have been no previous reports of AGEP induced by the ingestion of bamifylline in the medical literature. We, therefore, add this drug to the list of causes for AGEP.