RESUMO
The Impact of Pediatric Epilepsy Scale (IPES) is a brief, accurate, and acceptable measurement scale of the impact of pediatric epilepsy on the health-related quality of life (HRQOL) of both the child and the child's family as perceived by the child's parent(s). The aim of this study was to validate a Spanish language version of the IPES in Cuban children with epilepsy. The IPES was translated and adapted to Cuban culture and administered to 76 parents of children with epilepsy. The principal component analysis indicated that two factors accounted for 72% of the variance of the IPES (family relationships and health and social well-being). The IPES was also able to detect differences in HRQOL between subjects according to epilepsy severity. The internal consistency coefficient was 0.962, and the test-retest reliability was 0.979. The Cuban version of IPES can be used to measure a child's epilepsy-specific HRQOL in Cuba.
Assuntos
Epilepsia/diagnóstico , Epilepsia/epidemiologia , Pediatria , Perfil de Impacto da Doença , Análise de Variância , Cuba/epidemiologia , Epilepsia/psicologia , Feminino , Humanos , Masculino , Qualidade de Vida , Reprodutibilidade dos Testes , Tradução , Escala Visual AnalógicaRESUMO
OBJECTIVE: To explore the value of blood markers for brain injury as outcome predictors in acute stroke. DESIGN AND METHODS: The study included 61 patients with acute stroke (44 ischemic and 17 hemorrhagic) and a high risk control group (79 individuals with no known history of neurological disease). Serum neuron specific enolase (NSE) and S100B were determined by immunoassay (CanAg Diagnostics, Sweden). Outcome at 60 days was evaluated with clinical scales. RESULTS: Higher concentrations of NSE and S100B were measured in patients compared to high risk controls, but they were not related to stroke severity on admission. NSE was associated with functional neurological outcome at 60 days and to the degree of recovery, whereas S100B exhibited a strong correlation with depression symptoms at 60 days. CONCLUSIONS: The measurements of serum concentrations of NSE and S100B after acute stroke may be clinically relevant for predicting functional neurological outcome and post-stroke depression, respectively.
Assuntos
Isquemia Encefálica/sangue , Hemorragias Intracranianas/sangue , Fatores de Crescimento Neural/sangue , Fosfopiruvato Hidratase/sangue , Proteínas S100/sangue , Adulto , Idoso , Idoso de 80 Anos ou mais , Isquemia Encefálica/diagnóstico , Isquemia Encefálica/psicologia , Depressão/sangue , Depressão/diagnóstico , Depressão/etiologia , Feminino , Humanos , Hemorragias Intracranianas/diagnóstico , Hemorragias Intracranianas/psicologia , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Prognóstico , Curva ROC , Análise de Regressão , Subunidade beta da Proteína Ligante de Cálcio S100 , Estatísticas não ParamétricasRESUMO
La enfermedad cerebrovascular (ECV) es una de las que tienen mayor impacto a nivel nacional e internacional, tanto por la mortalidad como por la pérdida de calidad de vida que genera en la población. En Cuba, con respecto a la morbilidad, este impacto no se ha cuantificado en un único índice que tenga en cuenta la severidad relativa de la ECV, es decir, su impacto sobre la calidad (y cantidad) de vida a la que aspiramos socialmente. La esperanza de vida ajustada por discapacidad (EVAD) es un indicador relativamente reciente que permite cuantificar el efecto de la morbilidad por cualquier enfermedad, en particular la ECV sobre la esperanza de vida. En este trabajo se calcula la EVAD para la ECV por sexo y para los años 1990, 1995 y 2000, lo que facilita el estudio comparativo del impacto de la morbilidad por esta enfermedad entre hombres y mujeres, y a lo largo del período abarcado por estos 3 años.
The cerebrovascular disease (CVD) is one of the diseases with the highest impact at the national and international level due to mortality and to the loss of quality of life it generates in the population. In Cuba, as regards morbidity, this impact has not been quantified in a unique index that takes into account the relative severity of the CVD, that is, its impact on the quality (and quantity) of life we all socially aspire to. Disability-adjusted life expectancy (DALE) is a relatively recent indicator that allows to quantify the effect of morbidity by any disease, in particular, the CVD, on life expectancy. In this paper, the DALE is calculated for the CVD by sex and for 1990, 1995 and 2000, which enables to conduct the comparative study of the impact of morbidity by this disease between men and women along this 3-year period.
RESUMO
Se realizó un estudio prospectivo tipo caso-control en pacientes y controles, para definir los principales desórdenes lipídicos en pacientes con infarto cerebral y comparar la relación de estos con factores de riesgo vascular. Se observaron valores significativamente más elevados de triglicéridos, lipoproteínas de baja densidad e índice aterogénico, en los pacientes respecto de los controles. No hubo diferencias para el colesterol total ni las lipoproteínas de muy baja densidad entre los 2 grupos. La hipertensión arterial como factor de riesgo se asoció con valores más bajos de lipoproteínas de alta densidad, y más elevados de lipoproteínas de baja densidad, triglicéridos, lipoproteínas de muy baja densidad e índice aterogénico. No se encontró relación entre la hipertensión arterial y el colesterol total. Se concluyó que era necesario controlar los lípidos en el infarto cerebral